Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Mounir, Tarek"'
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract Autophagy is a molecular process essential for maintaining cellular homeostasis, with its impairment or dysregulation linked to the progression of various diseases in mammals. Specific lipids, including phosphoinositides, sphingolipids, and
Externí odkaz:
https://doaj.org/article/1f84dffa37f247d483801bcf559d8cf2
Autor:
Wojciech Szlasa, Natalia Sauer, Dagmara Baczyńska, Marcin Ziętek, Katarzyna Haczkiewicz-Leśniak, Paweł Karpiński, Mariusz Fleszar, Paulina Fortuna, Michał J. Kulus, Aleksandra Piotrowska, Alicja Kmiecik, Agnieszka Barańska, Olga Michel, Vitalij Novickij, Mounir Tarek, Paulina Kasperkiewicz, Piotr Dzięgiel, Marzenna Podhorska-Okołów, Jolanta Saczko, Julita Kulbacka
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-22 (2024)
Abstract Nanosecond pulsed electric field (nsPEF) has emerged as a promising approach for inducing cell death in melanoma, either as a standalone treatment or in combination with chemotherapeutics. However, to date, there has been a shortage of studi
Externí odkaz:
https://doaj.org/article/174e1b35aa5c400d90f3014cade7e422
Autor:
Wojciech Szlasa, Olga Michel, Natalia Sauer, Vitalij Novickij, Damian Lewandowski, Paulina Kasperkiewicz, Mounir Tarek, Jolanta Saczko, Julita Kulbacka
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Nanosecond pulsed electric fields (nsPEF) have been shown to exert anticancer effects; however, little is known about the mechanisms triggered in cancer cells by nanosecond-length pulses, especially when low, sub-permeabilization voltage is
Externí odkaz:
https://doaj.org/article/9dc74400fb2545499e702a3ddd07333b
Publikováno v:
BBA Advances, Vol 3, Iss , Pp 100073- (2023)
The phosphatidyl-inositol-4,5-bisphosphate (PIP2) lipid has been shown to be crucial for the coupling between the voltage sensor and the pore of the potassium voltage-gated KV7 channel family, especially the KV7.1 channel. Expressed in the myocardium
Externí odkaz:
https://doaj.org/article/59b1963cbfbd4472ae566d8708108bb2
Autor:
Karolina Cierluk, Wojciech Szlasa, Joanna Rossowska, Mounir Tarek, Anna Szewczyk, Jolanta Saczko, Julita Kulbacka
Publikováno v:
Saudi Pharmaceutical Journal, Vol 28, Iss 11, Pp 1364-1373 (2020)
Cepharanthine (CEP) is a bisbenzylisoquinoline alkaloid. Molecular dynamics studies show that CEP interacts with Voltage-dependent anion channel (VDAC), inducing the voltage-independent channel narrowing. In the new conformation, transport between mi
Externí odkaz:
https://doaj.org/article/12a51fa7d9a041bb91c984ed1afc6db5
Autor:
Panpan Hou, Po Wei Kang, Audrey Deyawe Kongmeneck, Nien-Du Yang, Yongfeng Liu, Jingyi Shi, Xianjin Xu, Kelli McFarland White, Mark A. Zaydman, Marina A. Kasimova, Guiscard Seebohm, Ling Zhong, Xiaoqin Zou, Mounir Tarek, Jianmin Cui
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
In voltage-gated potassium (KV) channels, the voltage-sensing domain (VSD) undergoes activation states to trigger pore opening via electro–mechanical (E–M) coupling. Here authors show that KV7.1 undergoes a two-stage E–M coupling mechanism duri
Externí odkaz:
https://doaj.org/article/35fb6ed5769147e193c27d6349310d60
Autor:
Gildas Loussouarn, Mounir Tarek
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/9a151b273d9443d5ac9ce21bfec942f8
Autor:
David Siniscalco, Grégory Francius, Mounir Tarek, Semiha Kevser Bali, Olivier Laprévote, Catherine Malaplate, Thierry Oster, Lynn Pauron, Fabienne Quilès
Publikováno v:
ACS Applied Materials & Interfaces. 15:17507-17517
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::505f037c4f9c301932a2bb2465f93192
https://doi.org/10.1021/acsami.2c22196
https://doi.org/10.1021/acsami.2c22196
Autor:
Wojciech Szlasa, Aleksander Kiełbik, Anna Szewczyk, Vitalij Novickij, Mounir Tarek, Zofia Łapińska, Jolanta Saczko, Julita Kulbacka, Nina Rembiałkowska
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 20, p 11245 (2021)
Electroporation is influenced by the features of the targeted cell membranes, e.g., the cholesterol content and the surface tension of the membrane. The latter is eventually affected by the organization of actin fibers. Atorvastatin is a statin known
Externí odkaz:
https://doaj.org/article/938e90ef53d44377ae8705691d79e654
Autor:
Wojciech Szlasa, Aleksander Kiełbik, Anna Szewczyk, Nina Rembiałkowska, Vitalij Novickij, Mounir Tarek, Jolanta Saczko, Julita Kulbacka
Publikováno v:
Molecules, Vol 26, Iss 1, p 154 (2020)
Irreversible electroporation (IRE) is today used as an alternative to surgery for the excision of cancer lesions. This study aimed to investigate the oxidative and cytotoxic effects the cells undergo during irreversible electroporation using IRE prot
Externí odkaz:
https://doaj.org/article/874a1f3470c742eda97cedddb0a07431