Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Mounia Alaoui El Azher"'
Autor:
Sandra Vergara, Xiaohong Zhou, Ulises Santiago, Mounia Alaoui-El-Azher, James F. Conway, Nicolas Sluis-Cremer, Guillermo Calero
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Reverse transcription of the retroviral RNA genome into DNA is an integral step during HIV-1 replication. Despite a wealth of structural information on reverse transcriptase (RT), we lack insight into the intermediate states of DNA synthesis
Externí odkaz:
https://doaj.org/article/604c55c841a74a928827d4be162f45bf
Autor:
Alondra Vázquez Rivera, Heather Donald, Mounia Alaoui-El-Azher, John J. Skoko, John S. Lazo, Michael A. Parniak, Paul A. Johnston, Nicolas Sluis-Cremer
Publikováno v:
Biomolecules, Vol 14, Iss 7, p 819 (2024)
The ribonuclease H (RNase H) active site of HIV-1 reverse transcriptase (RT) is the only viral enzyme not targeted by approved antiretroviral drugs. Using a fluorescence-based in vitro assay, we screened 65,239 compounds at a final concentration of 1
Externí odkaz:
https://doaj.org/article/f8e64f106e54456d83df7089a79fcab8
Autor:
Abigail Gerberick, Diana C. DeLucia, Paolo Piazza, Mounia Alaoui-El-Azher, Charles R. Rinaldo, Nicolas Sluis-Cremer, Giovanna Rappocciolo
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
The latent human immunodeficiency virus type 1 (HIV-1) reservoir in persons on antiretroviral therapy (ART) represents a major barrier to a cure. Although most studies have focused on the HIV-1 reservoir in the memory T cell subset, replication-compe
Externí odkaz:
https://doaj.org/article/11fccc6919ab45b0891ec2ca00492129
SARS-CoV-2 mRNA Vaccine Induced Immune Responses in Men with HIV-1 and Impact on Proviral Reservoirs
Autor:
Dylan J. Tuttle, Priscila M. S. Castanha, Amro Nasser, Maris S. Wilkins, Mounia Alaoui-El-Azher, Deirdre E. Cuff, Prabal Chhibbar, Jishnu Das, Yijia Li, Simon M. Barratt-Boyes, Robbie B. Mailliard, Nicolas P. Sluis-Cremer, Charles R. Rinaldo, Ernesto T. A. Marques
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3408823ceb3714e71691842d2abd93d2
https://doi.org/10.2139/ssrn.4417076
https://doi.org/10.2139/ssrn.4417076
Autor:
Muhamuda Kader, Mounia Alaoui-El-Azher, Jennie Vorhauer, Bhushan B Kode, Jakob Z Wells, Donna Stolz, George Michalopoulos, Alan Wells, Melanie Scott, Nahed Ismail
Publikováno v:
PLoS Pathogens, Vol 13, Iss 10, p e1006644 (2017)
Severe hepatic inflammation is a common cause of acute liver injury following systemic infection with Ehrlichia, obligate Gram-negative intracellular bacteria that lack lipopolysaccharide (LPS). We have previously shown that type I IFN (IFN-I) and in
Externí odkaz:
https://doaj.org/article/f6fc2924cfa0408dae6cc05fe987328f
Autor:
Denise Prosser, Esther Elishaev, Mounia Alaoui El Azher, Liudmila Velikokhatnaya, Paul M. Stemmer, Namhee Shin, Francesmary Modugno, Anna Lokshin, Dmitriy W. Gutkin, Galina V. Shurin, Michael R. Shurin
Publikováno v:
Cancer Biomarkers. 26:471-479
Ovarian cancer is the leading cause of death among gynecologic diseases in the USA and Europe. High-grade serous carcinoma (HGSC) of the ovary, the most aggressive type of ovarian cancer, is typically diagnosed at advanced stages when the 5-year surv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f37bf9565a072a17b9c78a5ba53184c
https://doi.org/10.3233/cbm-190528
https://doi.org/10.3233/cbm-190528
Autor:
Mounia Alaoui-El-Azher, Paolo Piazza, Abigail Gerberick, Charles R. Rinaldo, Giovanna Rappocciolo, Nicolas Sluis-Cremer, Diana C. DeLucia
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
Insight into the establishment and maintenance of HIV-1 infection in resting CD4+ T cell subsets is critical for the development of therapeutics targeting the HIV-1 reservoir. Although the frequency of HIV-1 infection, as quantified by the frequency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f587a98eeb6fbc955b95124ce578de5d
https://doi.org/10.1128/mbio.02998-20
https://doi.org/10.1128/mbio.02998-20
Autor:
Charles R. Rinaldo, Mounia Alaoui-El-Azher, Paolo Piazza, Abigail Gerberick, Giovanna Rappocciolo, Diana C. DeLucia, Nicolas Sluis-Cremer
Insight into the establishment and maintenance of HIV-1 infection in resting CD4+ T cell subsets is critical for the development of therapeutics targeting the HIV-1 reservoir. Although the frequency of HIV-1 infection, as quantified by the frequency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::167c967d8f22fd1bd4f03d4a7cc76840
https://doi.org/10.1101/2020.10.22.351627
https://doi.org/10.1101/2020.10.22.351627
Autor:
Mounia Alaoui-El-Azher, Jeffrey J Mans, Henry V Baker, Casey Chen, Ann Progulske-Fox, Richard J Lamont, Martin Handfield
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11714 (2010)
The cytolethal distending toxin (CDT) of the oral pathogen Aggregatibacter actinomycetemcomitans induces cell cycle arrest and apoptosis in various cell types. Western analysis, pharmacological inhibition and siRNA silencing were performed in human i
Externí odkaz:
https://doaj.org/article/4c585a9a498e4b3f8538221ae173effd
Autor:
Melanie J. Scott, Mounia Alaoui-El-Azher, Donna B. Stolz, Alan Wells, George K. Michalopoulos, Nahed Ismail, Jakob Z. Wells, Muhamuda Kader, Jennie Vorhauer, Bhushan B Kode
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 13, Iss 10, p e1006644 (2017)
PLoS Pathogens, Vol 13, Iss 10, p e1006644 (2017)
Severe hepatic inflammation is a common cause of acute liver injury following systemic infection with Ehrlichia, obligate Gram-negative intracellular bacteria that lack lipopolysaccharide (LPS). We have previously shown that type I IFN (IFN-I) and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18004ab933ac9cad9522eb08b0631736
http://europepmc.org/articles/PMC5663626
http://europepmc.org/articles/PMC5663626