Antitherapeutic antibody-mediated hepatotoxicity of recombinant human Apo2L/TRAIL in the cynomolgus monkey.

Autor: Zuch de Zafra CL; Safety Assessment, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Ashkenazi A; Department of Cancer Immunology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Darbonne WC; Oncology Biomarker Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Cheu M; BioAnalytical Sciences, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Totpal K; Department of Cancer Immunology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Ortega S; Safety Assessment, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Flores H; Late Stage Pharmaceutical Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Walker MD; Charles River Laboratories Inc. (formerly Sierra Biomedical), 587 Dunn Circle, Sparks, NV 89431, USA., Kabakoff B; Early Stage Pharmaceutical Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Lum BL; Clinical Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Mounho-Zamora BJ; Toxicology Department, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA., Marsters SA; Department of Cancer Immunology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Dybdal NO; Safety Assessment, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

Publikováno v: Cell death & disease [Cell Death Dis] 2016 Aug 11; Vol. 7 (8), pp. e2338. Date of Electronic Publication: 2016 Aug 11.