Myofibroblast modulation of cardiac myocyte structure and function

Autor: Chandan K. Nagaraju, Eef Dries, Guillaume Gilbert, Mouna Abdesselem, Nan Wang, Matthew Amoni, Ronald B. Driesen, Karin R. Sipido

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)

Abstract After myocardial infarction, resident fibroblasts (Fb) differentiate towards myofibroblasts (MyoFb), generating the scar tissue and the interstitial fibrosis seen in the adjacent myocardium. Fb and MyoFb have the potential to interact with c

Externí odkaz: https://doaj.org/article/d7d7434f9c4241de92ebb91f7526f189

Altered adrenergic response in myocytes bordering a chronic myocardial infarction underlies in vivo triggered activity and repolarization instability

Autor: Guillaume Gilbert, Bert Vandenberk, Demetrio J. Santiago, Daniel M. Johnson, Chandan K. Nagaraju, Karin R. Sipido, Rik Willems, H. Llewelyn Roderick, Matthew Amoni, Piet Claus, Rosa Doñate Puertas, Eef Dries, Mouna Abdesselem

Publikováno v: Repisalud
Instituto de Salud Carlos III (ISCIII)
The Journal of Physiology

Key points Ventricular arrhythmias are a major complication after myocardial infarction (MI), associated with sympathetic activation. The structurally heterogeneous peri‐infarct zone is a known substrate, but the functional role of the myocytes is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6c0bb59f1b5d4c56505775a273b9ba5
http://hdl.handle.net/20.500.12105/11258

Myofibroblast Phenotype and Reversibility of Fibrosis in Patients With End-Stage Heart Failure

Autor: Emma L. Robinson, Johan Van Cleemput, Filip Rega, Ronald B. Driesen, Guillaume Gilbert, Chandan K. Nagaraju, Sander Trenson, Stefan Janssens, Karin R. Sipido, H. Llewelyn Roderick, Mouna Abdesselem, Eef Dries, Bart Meyns

Publikováno v: Journal of the American College of Cardiology
Journal of the American College of Cardiology, 73(18), 2267-2282. Elsevier Science

BACKGROUND: Interstitial fibrosis is an important component of diastolic, and systolic, dysfunction in heart failure (HF) and depends on activation and differentiation of fibroblasts into myofibroblasts (MyoFb). Recent clinical evidence suggests that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2769e29f97fc4aabc4ae1182457ee56
https://lirias.kuleuven.be/handle/123456789/637585

ROS Detection and Quantification with Lanthanide-Based Nanosensors

Autor: Pierre-Louis Tharaux, Antigoni Alexandrou, Jean-Pierre Boilot, Mouna Abdesselem, Thierry Gacoin, Cedric Bouzigues

Publikováno v: 59th Annual Meeting of the Biophysical-Society
59th Annual Meeting of the Biophysical-Society, Feb 2015, Baltimore, United States. Biophysical Journal, 108 (2), pp.483a, 2015, ⟨10.1016/j.bpj.2014.11.2640⟩
59th Annual Meeting of the Biophysical-Society, Feb 2015, Baltimore, United States. Biophysical Journal, 108 (2), pp.483a, 2015, 〈10.1016/j.bpj.2014.11.2640〉

International audience; Reactive oxygen species (ROS), in particular hydrogen peroxide (H2O2), are produced as secondary cellular messengers involved in a variety of signaling pathways. Detecting ROS concentration in cells and in living organisms is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e35603d17c7e3e099fc8df4437fc6f7
https://hal-polytechnique.archives-ouvertes.fr/hal-01237532

Multifunctional rare-Earth vanadate nanoparticles: luminescent labels, oxidant sensors, and MRI contrast agents

Autor: Rivo Ramodiharilafy, Gwennhael Autret, Olivier Clément, Pierre-Louis Tharaux, Mouna Abdesselem, Isabelle Maurin, Markus Schoeffel, Cedric Bouzigues, Thierry Gacoin, Jean-Pierre Boilot, Antigoni Alexandrou

Publikováno v: ACS Nano
ACS Nano, American Chemical Society, 2014, 8 (11), pp.11126-37

International audience; Collecting information on multiple pathophysiological parameters is essential for understanding complex pathologies, especially given the large interindividual variability. We report here multifunctional nanoparticles which ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1413c8989f9fd07f6a30d40fa1ce5c04
https://hal-polytechnique.archives-ouvertes.fr/hal-01102505