Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Moulay Hicham Alaoui Ismaili"'
Autor:
William C. Hallows, Kristen Skvorak, Nick Agard, Nikki Kruse, Xiyun Zhang, Yu Zhu, Rachel C. Botham, Chinping Chng, Charu Shukla, Jessica Lao, Mathew Miller, Antoinette Sero, Judy Viduya, Moulay Hicham Alaoui Ismaili, Kerryn McCluskie, Raphael Schiffmann, Adam P. Silverman, Jin-Song Shen, Gjalt W. Huisman
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Fabry disease is caused by a deficiency of α-galactosidase A (GLA) leading to the lysosomal accumulation of globotriaosylceramide (Gb3) and other glycosphingolipids. Fabry patients experience significant damage to the heart, kidney, and blo
Externí odkaz:
https://doaj.org/article/b25ba72e3abd48129972a8895661aad7
Autor:
Ioana Neagoe, Chang Liu, Alexander Stumpf, Yanmei Lu, Dongping He, Ross Francis, Jun Chen, Paul Reynen, Moulay Hicham Alaoui-Ismaili, Hirokazu Fukui
Publikováno v:
Stem Cell Research, Vol 28, Iss , Pp 105-114 (2018)
Abnormal signaling pathways mediated by N-methyl-d-aspartate receptors (NMDARs) have been implicated in the pathogenesis of various CNS disorders and have been long considered as promising points of therapeutic intervention. However, few efforts have
Externí odkaz:
https://doaj.org/article/173841831bd44134a7e86a96a12cf370
Autor:
James J. Crawford, Jianwen Feng, Hans D. Brightbill, Adam R. Johnson, Matthew Wright, Aleksandr Kolesnikov, Wendy Lee, Georgette M. Castanedo, Steven Do, Nicole Blaquiere, Steven T. Staben, Po-Chang Chiang, Peter W. Fan, Matt Baumgardner, Susan Wong, Robert Godemann, Alice Grabbe, Catharina Wiegel, Swathi Sujatha-Bhaskar, Sarah G. Hymowitz, Nicholas Liau, Peter L. Hsu, Paul A. McEwan, Moulay Hicham Alaoui Ismaili, Matthew L. Landry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb21c9e6dbe8d70e0d41f1c745caf358
https://doi.org/10.2139/ssrn.4345205
https://doi.org/10.2139/ssrn.4345205
Autor:
Peter W. Fan, Sarah G. Hymowitz, Teresa Dong, Xingyu Lin, Zoe Zhong, Connie Chan, Paul A. McEwan, Wyne P. Lee, Swathi Sujatha-Bhaskar, Baihua Hu, Nicole Blaquiere, Jason Burch, Jianwen Feng, Hans Brightbill, Steven T. Staben, Alison J Hole, James J. Crawford, Guosheng Wu, Suzanne Brown, Moulay Hicham Alaoui Ismaili, Georgette Castanedo, Patrick Lee, Hoa Le, Leonid M. Berezhkovskiy, Po-Chang Chiang, Robert Godemann, Brent S. McKenzie, Emily B. Gogol, Hernani L Silvestre, Ning Liu, Eric Suto, Nico Ghilardi, Yamin Zhang, Lawren C. Wu, Alice Grabbe
Publikováno v:
Journal of Medicinal Chemistry. 61:6801-6813
NF-κB-inducing kinase (NIK) is a protein kinase central to the noncanonical NF-κB pathway downstream from multiple TNF receptor family members, including BAFF, which has been associated with B cell survival and maturation, dendritic cell activation
Autor:
Eric Suto, Lawren C. Wu, Karin Bents, Justin Lesch, Benjamin T. Jackson, Peter W. Fan, Wyne P. Lee, Laura Christian, Nicole Blaquiere, Nandhini Ramamoorthi, Adam R. Johnson, Emily B. Gogol, Steven T. Staben, Susan Haller, Pawan Bir Kohli, Zora Modrusan, Sandra Linge, Jason DeVoss, James J. Crawford, Christine Everett, Kelli Veliz, Leonid M. Berezhkovskiy, Jason A. Hackney, Georgette Castanedo, Allan Jaochico, Cary D. Austin, Nico Ghilardi, Youngsu Kwon, Swathi Sujatha-Bhaskar, Robert Godemann, Hans Brightbill, Michael J. Townsend, Moulay Hicham Alaoui Ismaili, Brent S. McKenzie, Kathy Barrett
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications
Nature Communications
NF-κB-inducing kinase (NIK) mediates non-canonical NF-κB signaling downstream of multiple TNF family members, including BAFF, TWEAK, CD40, and OX40, which are implicated in the pathogenesis of systemic lupus erythematosus (SLE). Here, we show that
Autor:
Moulay Hicham Alaoui Ismaili, Peter W. Fan, Cornelis E. C. A. Hop, Brian Dean, Yuan Chen, Jianshuang Wang, Matthew Wright, Susan Wong, Jialin Mao
Publikováno v:
Pharmaceutical Research. 34:2403-2414
The exposure of G2917 decreased by four-fold at oral doses of 100 mg/kg twice daily for seven days in cynomolgus monkeys. Additional investigative work was conducted to understand: (1) the causes for the significant reduction in G2917 exposure in mon
Autor:
Brent S. McKenzie, Eric Suto, Lawren C. Wu, Ivan Peng, Jeffrey Eastham-Anderson, Connie Chan, Lorena Riol-Blanco, Kate Senger, Ali A. Zarrin, Tracy Staton, Janet Jackman, Justin Lesch, Allan Jaochico, Surinder Jeet, Nico Ghilardi, Jason DeVoss, Joshua D. Webster, Joseph R. Arron, Hai Ngu, Jason Burch, Yonglian Sun, Kathy Barrett, Charles Havnar, Yuan Chen, Zhonghua Pei, Cary D. Austin, Jenna L. Collier, Olga Li, George Francis, Meijuan Zhou, Wyne P. Lee, David F. Choy, Xiumin Wu, Moulay Hicham Alaoui Ismaili
Publikováno v:
Science Signaling. 8
Interleukin-2 (IL-2)-inducible T cell kinase (ITK) mediates T cell receptor (TCR) signaling primarily to stimulate the production of cytokines, such as IL-4, IL-5, and IL-13, from T helper 2 (TH2) cells. Compared to wild-type mice, ITK knockout mice
Publikováno v:
Cytokine & Growth Factor Reviews. 20:501-507
Bone morphogenetic proteins (BMPs) are growth factors belonging to the TGF beta super family. To date, more than twenty human BMPs have been identified. Of these, BMP-2 and BMP-7 (also known as osteogenic protein 1 or OP-1) are the only BMPs used cli
Autor:
Moulay Hicham Alaoui-Ismaili, Alexander R. Vaccaro, Joseph Hong, Dean Falb, Huub Schellekens, James P. Lawrence, Chang Ju Hwang
Publikováno v:
Journal of Neurosurgery: Spine. 10:443-451
Object The object of this paper is to review the immunogenicity of bone morphogenetic proteins (BMPs) and to compare the results of the immunogenicity characterization and clinical consequences between recombinant human (rh)BMP-2 and recombinant huma
Publikováno v:
Journal of Biological Chemistry. 283:20948-20958
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-β superfamily of growth factors and are used clinically to induce new bone formation. The purpose of this study was to evaluate receptor utilization by BMP-2, BMP-4, BM