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Akademický článek

ICAM-1 Antisense Oligodeoxynucleotide Improves Islet Allograft Survival and Function

Autor: Stephen M. Katz M.D., Frank Bennett, Kim Stecker, James H. Clark, Tommy Phan, Mou-Er Wang, Barry D. Kahan, Stanislaw M. Stepkowski

Publikováno v: Cell Transplantation, Vol 9 (2000)

Expression of intercellular adhesion molecule-1 (ICAM-1) and its ligand, leukocyte function antigen-1 (LFA-1), after pancreatic islet transplantation may affect both nonspecific and alloantigen-specific phases of graft destruction. We examined the ef

Externí odkaz: https://doaj.org/article/283774fc266a46aa8f9f1af62f2303c2

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Lack of NF-κB1 (p105/p50) attenuates unloading-induced downregulation of PPARα and PPARα-regulated gene expression in rodent heart

Autor: Peter Razeghi, Stanislaw M. Stepkowski, Mou Er Wang, Keith A. Youker, Heinrich Taegtmeyer, Leonard Golfman

Publikováno v: Cardiovascular Research. 74:133-139

Unloading of the rodent heart activates the fetal gene program, decreases peroxisome proliferator-activated receptor alpha (PPARalpha) and PPARalpha-regulated gene expression (MCAD), and induces cardiomyocyte atrophy. NF-kappaB regulates the fetal ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6444370c32d271cf2e6c71f13757119
https://doi.org/10.1016/j.cardiores.2006.12.021

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Methoxyethyl-Modified Intercellular Adhesion Molecule-1 Antisense Phosphorothiateoligonucleotides Inhibit Allograft Rejection, Ischemic-Reperfusion Injury, and Cyclosporine-Induced Nephrotoxicity

Autor: Lucrezia Furian, Regina R. Verani, Kim Stecker, Stanislaw M. Stepkowski, T. P. Condon, Xuimei Qu, Richard S. Geary, C. Frank Bennett, S Janczewska, Robert M. Langer, Mou-Er Wang, W. Chen

Publikováno v: Transplantation. 79:401-408

Background The addition of phosphorothioate (PS) groups to natural phosphodiester (PD) antisense oligodeoxynucleotides (oligo) prevents their in vivo hydrolysis by nucleases allowing an RNase-dependent elimination of targeted mRNA. To further improve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e7129ab23ea56e63c73554e1659b42
https://doi.org/10.1097/01.tp.0000149505.53886.27

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Selectin Inhibitor Bimosiamose Prolongs Survival of Kidney Allografts by Reduction in Intragraft Production of Cytokines and Chemokines

Autor: Robert A. Kirken, Robert M. Langer, Ping Li, Brian Dupre, Lily Feng, Richard A.F. Dixon, Barry D. Kahan, H Podder, Mou-Er Wang, Rongxiang Han, Kurt L. Berens, Stanislaw M. Stepkowski, Wayne W. Hancock

Publikováno v: Journal of the American Society of Nephrology. 15:2893-2901

Binding of the P-, L-, and E-selectins to sialyl Lewis(x) (sLe(x)) retards circulating leukocytes, thereby facilitating their attachment to the blood vessels of allografts. Whether the selectin inhibitor bimosiamose (BIMO; C(46)H(54)O(16) . 0.25 H(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc90a1c80527f886cfd6ccd5a6f851d7
https://doi.org/10.1097/01.asn.0000142425.23036.ac

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Selection of lowly immunogenic and highly tolerogenic donor and recipient allochimeric class I major histocompatibility complex proteins

Autor: Stanislaw M. Stepkowski, Barton W. Trawick, John Perez, Mou-Er Wang, Barry D. Kahan, S. Janczewska, Ping Song

Publikováno v: Transplantation. 76:1201-1207

Background, Ten different highly polymorphic amino acids (AAs) are located in the al (α 1h ) and a2 (α 2h ) helical regions of the class I major histocompatibility complex RT1.A n rat alloantigen. We examined the potential of α 1h -RT1.A n versus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e2893de3a4f03c8e2c5609622a77def
https://doi.org/10.1097/01.tp.0000082544.46595.f7

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Deoxycorticosterone Upregulates PDS ( Slc26a4 ) in Mouse Kidney

Autor: Kathryn A. Hassell, Susan M. Wall, Ines E. Royaux, Eric D. Green, Lorraine A. Everett, Mou-Er Wang, Jill W. Verlander, Dawn M. Glapion

Publikováno v: Hypertension. 42:356-362

Pendrin is an anion exchanger expressed along the apical plasma membrane and apical cytoplasmic vesicles of type B and of non-A, non-B intercalated cells of the distal convoluted tubule, connecting tubule, and cortical collecting duct. Thus, Pds ( Sl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d374d5d153a42f6d73718f9767b7eac
https://doi.org/10.1161/01.hyp.0000088321.67254.b7

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Allochimeric class I MHC protein-induced tolerance by partial TCR engagement requires activation of both CTL4- and common ??-chain-dependent cytokine signals1

Autor: Stanislaw M. Stepkowski, Min Wang, James H. Clark, Barton W. Trawick, Mou Er Wang, Barry D. Kahan, Robert A. Kirken, L Tian, Neelam Tejpal

Publikováno v: Transplantation. 73:1227-1235

Background. The various toxicities associated with the general immune suppression resulting from current clinical immunosuppressive therapies continue to plague transplant recipients as well as jeopardize allograft survival. Methods. The present stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1cb67a80192efeca52203258e5a70ac3
https://doi.org/10.1097/00007890-200204270-00007

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SELECTIVE INHIBITION OF IL-2 GENE EXPRESSION BY IL-2 ANTISENSE OLIGONUCLEOTIDES BLOCKS HEART ALLOGRAFT REJECTION1

Autor: Stanislaw M. Stepkowski, Xiumei Qu, Robert A. Kirken, C. Frank Bennett, Mou Er Wang, L Tian

Publikováno v: Transplantation. 72:915-923

Purpose. We tested the effects of selective inhibition of interleukin (IL)-2 gene expression by IL-2 antisense oligonucleotide (oligo) with phosphorothioate (PS)/ phosphodiester (PD)/2'-methoxyethyl (ME) modifications (17359) on T-cell function and t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80df25f0e70c05f78aa064cea825b291
https://doi.org/10.1097/00007890-200109150-00029

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INHIBITION OF C-RAF EXPRESSION BY ANTISENSE OLIGONUCLEOTIDES EXTENDS HEART ALLOGRAFT SURVIVAL IN RATS1

Autor: Brett P. Monia, Stanislaw M. Stepkowski, Wenhao Chen, Edward Wancewicz, L Tian, C. F. Bennett, Johnston Jf, Mou-Er Wang, Xiumei Qu

Publikováno v: Transplantation. 70:656-661

Background. C-raf is a well-characterized serine/ threonine (Ser/Thr) protein kinase that is involved in the transduction of multiple signals of T cells. We demonstrate that the inhibition of C-raf mRNA expression prolongs heart allograft survival. M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6e906ecbcc46bf73699b8380fadb77f
https://doi.org/10.1097/00007890-200008270-00020

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PERFUSION OF KIDNEYS WITH UNFORMULATED 'NAKED' INTERCELLULAR ADHESION MOLECULE-1 ANTISENSE OLIGODEOXYNUCLEOTIDES PREVENTS ISCHEMIC/REPERFUSION INJURY1

Autor: James H. Clark, W. Chen, S M Stepkowski, Kahan Bd, C. F. Bennett, K. Stecker, D. Dragun, Mou-Er Wang, Ling Tian

Publikováno v: Transplantation. 68:880-887

Background. We have previously shown that phosphorothioate intercellular adhesion molecule (ICAM)-1 antisense oligodeoxynucleotide (oligo) IP-9125 blocks the expression of rat ICAM-1 mRNA in rat L2 cells. A single ex situ perfusion of grafts with unf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::964927a8a2055b6411fbffd1f7b62493
https://doi.org/10.1097/00007890-199909270-00022

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