ER translocon inhibitor ipomoeassin F inhibits triple-negative breast cancer growth via blocking ER molecular chaperones.

Autor: Tao S; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China., Yang EJ; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China., Zong G; Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, USA., Mou PK; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China., Ren G; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China., Pu Y; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China., Chen L; Shenzhen Laboratory of Tumor Cell Biology, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China., Kwon HJ; Chemical Genomics Leader Research Laboratory, Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Korea., Zhou J; Department of Biological Sciences, University of Arkansas, Fayetteville, Arkansas 72701, USA., Hu Z; Feinstein Institute for Medical Research, Northwell Health, 350 Community Dr., Manhasset, New York, 11030, USA., Khosravi A; Department of Chemistry, Ball State University, Muncie, Indiana 47306, USA., Zhang Q; Department of Mathematical Sciences, University of Arkansas, Arkansas 72701, USA., Du Y; Department of Biological Sciences, University of Arkansas, Fayetteville, Arkansas 72701, USA., Shi WQ; Department of Chemistry, Ball State University, Muncie, Indiana 47306, USA., Shim JS; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China.; MOE Frontiers Science Centre for Precision Oncology, University of Macau, Taipa, Macau SAR, China.

Publikováno v: International journal of biological sciences [Int J Biol Sci] 2023 Jul 31; Vol. 19 (13), pp. 4020-4035. Date of Electronic Publication: 2023 Jul 31 (Print Publication: 2023).

Aurora kinase A inhibition induces synthetic lethality in SMAD4-deficient colorectal cancer cells via spindle assembly checkpoint activation.

Autor: Shi C; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China.; MOE Frontiers Science Centre for Precision Oncology, University of Macau, Taipa, Macau SAR, China.; Nanjing Maternity and Child Health Care Institute, Women's Hospital of Nanjing Medical University (Nanjing Maternity and Child Health Care Hospital), Nanjing, China., Tao S; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China.; MOE Frontiers Science Centre for Precision Oncology, University of Macau, Taipa, Macau SAR, China., Ren G; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China.; MOE Frontiers Science Centre for Precision Oncology, University of Macau, Taipa, Macau SAR, China., Yang EJ; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China.; MOE Frontiers Science Centre for Precision Oncology, University of Macau, Taipa, Macau SAR, China., Shu X; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China.; MOE Frontiers Science Centre for Precision Oncology, University of Macau, Taipa, Macau SAR, China., Mou PK; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China.; MOE Frontiers Science Centre for Precision Oncology, University of Macau, Taipa, Macau SAR, China., Liu Y; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China.; MOE Frontiers Science Centre for Precision Oncology, University of Macau, Taipa, Macau SAR, China., Dang Y; Center for Novel Target and Therapeutic Intervention, Institute of Life Sciences, Chongqing Medical University, Chongqing, China., Xu X; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China.; MOE Frontiers Science Centre for Precision Oncology, University of Macau, Taipa, Macau SAR, China., Shim JS; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China. jsshim@um.edu.mo.; MOE Frontiers Science Centre for Precision Oncology, University of Macau, Taipa, Macau SAR, China. jsshim@um.edu.mo.

Publikováno v: Oncogene [Oncogene] 2022 May; Vol. 41 (19), pp. 2734-2748. Date of Electronic Publication: 2022 Apr 07.

Aurora kinase A, a synthetic lethal target for precision cancer medicine.

Autor: Mou PK; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China., Yang EJ; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China., Shi C; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China., Ren G; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China., Tao S; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China., Shim JS; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China. jsshim@um.edu.mo.; MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macau SAR, China. jsshim@um.edu.mo.

Publikováno v: Experimental & molecular medicine [Exp Mol Med] 2021 May; Vol. 53 (5), pp. 835-847. Date of Electronic Publication: 2021 May 28.

Synthetic lethality of RB1 and aurora A is driven by stathmin-mediated disruption of microtubule dynamics.

Autor: Lyu J; Cancer Centre, Faculty of Health Sciences, University of Macau, Avenida da Universidade, Taipa, Macau, SAR, China., Yang EJ; Cancer Centre, Faculty of Health Sciences, University of Macau, Avenida da Universidade, Taipa, Macau, SAR, China., Zhang B; Cancer Centre, Faculty of Health Sciences, University of Macau, Avenida da Universidade, Taipa, Macau, SAR, China., Wu C; Cancer Centre, Faculty of Health Sciences, University of Macau, Avenida da Universidade, Taipa, Macau, SAR, China., Pardeshi L; Cancer Centre, Faculty of Health Sciences, University of Macau, Avenida da Universidade, Taipa, Macau, SAR, China., Shi C; Cancer Centre, Faculty of Health Sciences, University of Macau, Avenida da Universidade, Taipa, Macau, SAR, China., Mou PK; Cancer Centre, Faculty of Health Sciences, University of Macau, Avenida da Universidade, Taipa, Macau, SAR, China., Liu Y; Cancer Centre, Faculty of Health Sciences, University of Macau, Avenida da Universidade, Taipa, Macau, SAR, China., Tan K; Cancer Centre, Faculty of Health Sciences, University of Macau, Avenida da Universidade, Taipa, Macau, SAR, China., Shim JS; Cancer Centre, Faculty of Health Sciences, University of Macau, Avenida da Universidade, Taipa, Macau, SAR, China. jsshim@um.edu.mo.

Publikováno v: Nature communications [Nat Commun] 2020 Oct 09; Vol. 11 (1), pp. 5105. Date of Electronic Publication: 2020 Oct 09.