Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Mototsugu Ito"'
Autor:
Katie F. Maass, Matthew D. Barfield, Mototsugu Ito, Christopher A. James, Olga Kavetska, Marc Kozinn, Parag Kumar, Maureen Lepak, Luc Alexis Leuthold, Wenkui Li, Dmitri Mikhailov, Shefali Patel, Nisha L. Perez, Deanne Jackson Rudd, Blisse Vakkalagadda, Tracy M. Williams, Jiuhong Zha, Xin Zhang, Melanie D. Anderson
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 12, Pp 2785-2795 (2022)
Abstract Advances in the technologies to enable patient‐centric sampling (PCS) have the potential to improve blood sample collection by enabling clinical trial participants to collect samples via self‐collection or with the help of a caregiver in
Externí odkaz:
https://doaj.org/article/f47514d4b3894b97bd40e254dde58d06
Autor:
Mototsugu Ito, Mark Walzer, Mary Beth Blauwet, Anna Spence, Nakyo Heo, Debra Kelsh, Paul Blahunka, Jay Erdman, Mohamad Nour Alsharif, Gerard J Marek
Publikováno v:
Journal of Psychopharmacology. 37:449-461
Background: Recent increases in opioid use and subsequent opioid use disorder are a major public health crisis in the United States. Aims: This phase 1 randomized, placebo-controlled study investigated the safety, tolerability, and pharmacokinetics (
Autor:
Mototsugu Ito, Mark Walzer, Mary Beth Blauwet, Anna Spence, Nakyo Heo, Debra Kelsh, Paul Blahunka, Jay Erdman, Mohamad Nour Alsharif, Gerard J Marek
Publikováno v:
Journal of Psychopharmacology. 37:144-154
Background: There is an unmet need for therapeutics with greater efficacy and tolerability for the treatment of opioid use disorder (OUD). ASP8062 is a novel compound with positive allosteric modulator activity on the γ-aminobutyric acid type B rece
Autor:
Mototsugu, Ito, Anna, Spence, Mary Beth, Blauwet, Nakyo, Heo, Ronald, Goldwater, Paul, Maruff, Gerard J, Marek
Publikováno v:
Journal of Psychopharmacology. 36:756-767
Background: ASP8062 is a novel orally active GABAB receptor positive allosteric modulator in clinical development for the treatment of alcohol use disorder (AUD) and opioid use disorder (OUD). Aims: This study assessed the potential pharmacokinetic/p
Autor:
Mototsugu Ito, Tomasz Wojtkowski, Ronald A. Smulders, Akihiro Yamada, Ronald Goldwater, Akira Koibuchi, Tolga Uz, Sitra Tauscher-Wisniewski, Gerard J. Marek
Publikováno v:
Muscle & Nerve. 65:110-120
Introduction/aims ASP0367, or bocidelpar sulfate, is an orally administered small molecule that potently and selectively modulates peroxisome proliferator-activated receptor δ (PPARδ) to address mitochondrial dysfunction occurring in diseases inclu
Autor:
Mototsugu, Ito, Sitra, Tauscher-Wisniewski, Ronald A, Smulders, Tomasz, Wojtkowski, Akihiro, Yamada, Akira, Koibuchi, Tolga, Uz, Gerard J, Marek, Ronald D, Goldwater
Publikováno v:
Musclenerve. 65(1)
ASP0367, or bocidelpar sulfate, is an orally administered small molecule that potently and selectively modulates peroxisome proliferator-activated receptor δ (PPARδ) to address mitochondrial dysfunction occurring in diseases including primary mitoc
Autor:
Hiroyuki Kusuhara, Mototsugu Ito, Atsushi Ose, Kazunari Tanabe, Shigeru Horita, Takuya Fujita, Tsunenori Kondo, Hideki Nakayama, Yuichi Sugiyama
Publikováno v:
The AAPS Journal. 19:286-297
Oseltamivir (Tamiflu®) is a prodrug of Ro 64-0802, a selective inhibitor of influenza virus neuraminidase. There is a possible relationship between oseltamivir treatment and neuropsychiatric adverse events; although this has not been established, cl
Autor:
Takeshi Ueda, Seiji Naito, Tsutomu Nishiyama, Taiji Tsukamoto, Mototsugu Ito, Rio Akazawa, Hidehito Kusuoka, Hideki Maeda, Seiichiro Ozono, Yasuo Ohashi, Hideyuki Akaza
Publikováno v:
Japanese Journal of Clinical Oncology
The 3-month dosing regimen of degarelix with maintenance doses of 360 and 480 mg was effective and safe for the treatment of Japanese patients with prostate cancer.
Objective To evaluate the efficacy and safety of degarelix 3-month depot in Japa
Objective To evaluate the efficacy and safety of degarelix 3-month depot in Japa
Autor:
Atsushi Ose, Kenzo Yamatsugu, Mototsugu Ito, John D. Schuetz, Masakiyo Hosokawa, Motomu Kanai, Hiroyuki Kusuhara, Masakatsu Shibasaki, Yuichi Sugiyama
Publikováno v:
Drug Metabolism and Disposition. 37:315-321
[3R,4R,5S]-4-Acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate phosphate (Ro 64-0802) is a pharmacologically active form of the anti-influenza virus drug oseltamivir. Abnormal behavior is a suspected adverse effect of oseltamivir on th
Publikováno v:
Biochemical and Biophysical Research Communications. 360:615-620
Phosphorylated double-stranded RNA-dependent protein kinase (PKR) is thought to play an important role during ER stress induced cell death, but its molecular mechanism of action has not yet been clarified completely. To resolve this issue, we employe