Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Mototsugu, Eiraku"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Early patterning of neural crest cells (NCCs) in the craniofacial primordium is important for subsequent development of proper craniofacial structures. However, because of the complexity of the environment of developing tissues, surveying th
Externí odkaz:
https://doaj.org/article/76839873891f4026b9124d55fadb1d5d
Autor:
Masato Ishikawa, Seiichi Sugino, Yoshie Masuda, Yusuke Tarumoto, Yusuke Seto, Nobuko Taniyama, Fumi Wagai, Yuhei Yamauchi, Yasuhiro Kojima, Hisanori Kiryu, Kosuke Yusa, Mototsugu Eiraku, Atsushi Mochizuki
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract Single-cell RNA-seq analysis coupled with CRISPR-based perturbation has enabled the inference of gene regulatory networks with causal relationships. However, a snapshot of single-cell CRISPR data may not lead to an accurate inference, since
Externí odkaz:
https://doaj.org/article/ad021f02ce49442c8318b1e0962d16d6
Autor:
Takashi Kanadome, Kanehiro Hayashi, Yusuke Seto, Mototsugu Eiraku, Kazunori Nakajima, Takeharu Nagai, Tomoki Matsuda
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Intensiometric N-cadherin (NCad) interaction indicators, named INCIDERs, visualize reversible NCad-mediated cell-cell interactions.
Externí odkaz:
https://doaj.org/article/6ec1765fe6784b969b6816424a72337b
Autor:
Guillermo Martínez-Ara, Núria Taberner, Mami Takayama, Elissavet Sandaltzopoulou, Casandra E. Villava, Miquel Bosch-Padrós, Nozomu Takata, Xavier Trepat, Mototsugu Eiraku, Miki Ebisuya
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Apical constriction is a force-generating process required during embryonic development; there is a lack of tools to manipulate 3D shapes of mammalian tissues. Here the authors report the optogenetic method, OptoShroom3, to achieve fast spatiotempora
Externí odkaz:
https://doaj.org/article/6b30781780f940a2b12488a8bc02e9e6
Autor:
Rio Tsutsumi, Mototsugu Eiraku
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Building limb morphogenesis in vitro would substantially open up avenues for research and applications of appendage development. Recently, advances in stem cell engineering to differentiate desired cell types and produce multicellular structures in v
Externí odkaz:
https://doaj.org/article/ae03c0e9718c4d00a40e933c45f79ad4
Autor:
Shunsuke Mori, Eriko Sakakura, Yuji Tsunekawa, Masaya Hagiwara, Takayuki Suzuki, Mototsugu Eiraku
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Organoid technology has been applied to model many types of organs in vitro, although structures containing multiple germ layers, such as limb buds, have not been generated. Here, the authors induce limb bud-like tissues from mouse ESCs that can be f
Externí odkaz:
https://doaj.org/article/9c137614642140f68597ed32179afbb5
Autor:
Hung-Ya Tu, Takehito Watanabe, Hiroshi Shirai, Suguru Yamasaki, Masaharu Kinoshita, Keizo Matsushita, Tomoyo Hashiguchi, Hirotaka Onoe, Take Matsuyama, Atsushi Kuwahara, Akiyoshi Kishino, Toru Kimura, Mototsugu Eiraku, Kiyoshi Suzuma, Takashi Kitaoka, Masayo Takahashi, Michiko Mandai
Publikováno v:
EBioMedicine, Vol 39, Iss , Pp 562-574 (2019)
Background: We have previously reported that xeno-transplanted human ESC-derived retinas are able to mature in the immunodeficient retinal degeneration rodent models, similar to allo-transplantations using mouse iPSC-derived retina. The photoreceptor
Externí odkaz:
https://doaj.org/article/9426142104d94319966b4aa705aca802
Autor:
Satoshi Iraha, Hung-Ya Tu, Suguru Yamasaki, Takahiro Kagawa, Motohito Goto, Riichi Takahashi, Takehito Watanabe, Sunao Sugita, Shigenobu Yonemura, Genshiro A. Sunagawa, Take Matsuyama, Momo Fujii, Atsushi Kuwahara, Akiyoshi Kishino, Naoshi Koide, Mototsugu Eiraku, Hidenobu Tanihara, Masayo Takahashi, Michiko Mandai
Publikováno v:
Stem Cell Reports, Vol 10, Iss 3, Pp 1059-1074 (2018)
Summary: Increasing demand for clinical retinal degeneration therapies featuring human ESC/iPSC-derived retinal tissue and cells warrants proof-of-concept studies. Here, we established two mouse models of end-stage retinal degeneration with immunodef
Externí odkaz:
https://doaj.org/article/fa518bf2e7cc40a39d80e76bea362d35
Autor:
Zhe Wang, Akira Numada, Fumi Wagai, Yusuke Oda, Masatoshi Ohgushi, Koichiro Maki, Taiji Adachi, Mototsugu Eiraku
Publikováno v:
Development (09501991); Mar2024, Vol. 151 Issue 6, p1-13, 13p
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
The neuroectoderm is patterned in a rostral-caudal axis in the embryo but how positional information is interpreted, is unclear. Here, the authors show that in mouse 3D embryonic stem cell cultures, there is self-patterning that depends on sequential
Externí odkaz:
https://doaj.org/article/1440dcdddfed461ca36cc2598fcdb630