Výsledky vyhledávání - "Motoshi Shoda"

AK106-001616, a Potent and Selective Inhibitor of Cytosolic Phospholipase A2: In Vivo Efficacy for Inflammation, Neuropathic Pain, and Pulmonary Fibrosis

Autor: Masakazu Komatsu, Hiroshi Kuriyama, Katsuhiko Sakurada, Akitoshi Ito, Yukiko Endo, Kosuke Tanaka, Tomohito Kozaki, Hirotomo Shimizu, Kenichi Saito, Motoshi Shoda, Junji Nakamura, Mineko Takeda

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 369:511-522

3-[3-Amino-4-(indan-2-yloxy)-5-(1-methyl-1H-indazol-5-yl)-phenyl]-propionic acid (AK106-001616) is a novel, potent, and selective inhibitor of the cytosolic phospholipase A2 (cPLA2) enzyme. Unlike traditional nonsteroidal anti-inflammatory drugs and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::71324a04fc85b10e740d66bc789e3daf
https://doi.org/10.1124/jpet.118.255034

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AK106-001616, a Potent and Selective Inhibitor of Cytosolic Phospholipase A

Autor: Hirotomo, Shimizu, Akitoshi, Ito, Katsuhiko, Sakurada, Junji, Nakamura, Kosuke, Tanaka, Masakazu, Komatsu, Mineko, Takeda, Kenichi, Saito, Yukiko, Endo, Tomohito, Kozaki, Motoshi, Shoda, Hiroshi, Kuriyama

Publikováno v: The Journal of pharmacology and experimental therapeutics. 369(3)

3-[3-Amino-4-(indan-2-yloxy)-5-(1-methyl-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f543f71e6aabf1ee0dffdbaab2943d26
https://pubmed.ncbi.nlm.nih.gov/30971478

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Synthesis of Erythrina and Related Alkaloids. XXXVI. Studies toward Total Synthesis of Non-aromatic Erythrina Alkaloids. 6. Synthesis of 8-Oxo-.GAMMA.-erythroidine and 8-Oxo-cycloerythroidine, Isomers of the Natural Alkaloids

Autor: Shinzo Hosoi, Motoshi Shoda, Yoshisuke Tsuda, Ryuzo Yamamoto, Takehiro Sano, J. Toda, Kimiaki Isobe, Hiromi Ando

Publikováno v: Chemical and Pharmaceutical Bulletin. 40:3145-3156

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f4ee8a036b35602863353e8ba8e90944
https://doi.org/10.1248/cpb.40.3145

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Synthesis of Erythrina and Related Alkaloids. XXXIV. Studies toward Total Synthesis of Non-aromatic Erythrina Alkaloids.(4). Oxidation of Furan Ring of D-Furanoerythrinans with N-Bromoacetamide

Autor: Kimiaki Isobe, Takehiro Sano, Motoshi Shoda, Yoshisuke Tsuda, Ryuzo Yamamoto, Jun Toda

Publikováno v: Chemical and Pharmaceutical Bulletin. 40:2663-2667

Oxidation of the furan ring in the D-furanoerythrinan 1 with N-bromoacetamide in protic solvents gave the dioxygenated dihydrofurans 4 or 6. Acidic treatment of 4 or 6 caused two kind of reactions depending on the conditions : one is regeneration of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d866e1720645d4ead50e8ca5cf346ee
https://doi.org/10.1248/cpb.40.2663

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