Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Motonori Tsuji"'
Autor:
Jun-ichi Wachino, Wanchun Jin, Chihiro Norizuki, Kouji Kimura, Motonori Tsuji, Hiromasa Kurosaki, Yoshichika Arakawa
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 3 (2024)
ABSTRACTMetallo-β-lactamases (MBLs) represent one of the main causes of carbapenem resistance in the order Enterobacterales. To combat MBL-producing carbapenem-resistant Enterobacterales, the development of MBL inhibitors can restore carbapenem effi
Externí odkaz:
https://doaj.org/article/c5c16986ebb24c6aac08e8f2fcf856b8
Autor:
Motonori Tsuji
Publikováno v:
FEBS Open Bio, Vol 10, Iss 6, Pp 995-1004 (2020)
A novel coronavirus [severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), or 2019 novel coronavirus] has been identified as the pathogen of coronavirus disease 2019. The main protease (Mpro, also called 3‐chymotrypsin‐like protease)
Externí odkaz:
https://doaj.org/article/23437ee0b240484e8c2a892ad94266bd
Autor:
Motonori Tsuji
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11009 (2022)
The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was identified as the pathogenic cause of coronavirus disease 2019 (COVID-19). The RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 is a potential target for the tr
Externí odkaz:
https://doaj.org/article/b1f0d876965e48c29292e7a9360e5977
Autor:
Riho Tateyama-Makino, Mari Abe-Yutori, Taku Iwamoto, Kota Tsutsumi, Motonori Tsuji, Satoru Morishita, Kei Kurita, Yukio Yamamoto, Eiji Nishinaga, Keiichi Tsukinoki
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0257705 (2021)
SARS-CoV-2 enters host cells when the viral spike protein is cleaved by transmembrane protease serine 2 (TMPRSS2) after binding to the host angiotensin-converting enzyme 2 (ACE2). Since ACE2 and TMPRSS2 are expressed in the tongue and gingival mucosa
Externí odkaz:
https://doaj.org/article/365d5128d3c246e2b88624dab652c34b
Publikováno v:
Chemicalpharmaceutical bulletin. 68(12)
Anisakiasis is common in countries where raw or incompletely cooked marine fish are consumed. Currently, effective therapeutic methods to treat anisakiasis are unavailable. A recent study found that wood creosote inactivates the movement of Anisakis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a31f38d6b3016d29c4d06fe0928829c
https://pubmed.ncbi.nlm.nih.gov/33268651
https://pubmed.ncbi.nlm.nih.gov/33268651
Autor:
Hiroto Mizushima, Pattara Wongjaroen, Prukswan Chetanachan, Motonori Tsuji, Yoshiharu Matsuura, Kriangsak Ruchusatsawat, Uamporn Siripanyaphinyo, Masashi Tatsumi, Tatsuo Shioda, Uranan Tumkosit, Atsushi Tanaka, Naokazu Takeda, Yusuke Maeda
Publikováno v:
J Virol
Chikungunya fever, a mosquito-borne disease manifested by fever, rash, myalgia, and arthralgia, is caused by chikungunya virus (CHIKV), which belongs to the genus Alphavirus of the family Togaviridae. Anti-CHIKV IgG from convalescent patients is know
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7bb04dafa68a8e7a0d54268d6823d2d
https://doi.org/10.1128/jvi.00252-20
https://doi.org/10.1128/jvi.00252-20
Autor:
Motonori Tsuji
Publikováno v:
Journal of Computer-Aided Molecular Design. 31:577-585
HX531, which contains a dibenzodiazepine skeleton, is one of the first retinoid X receptor (RXR) antagonists. Functioning via RXR-PPARγ heterodimer, this compound is receiving a lot of attention as a therapeutic drug candidate for diabetic disease c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f590f592b06fbccda2c17969c7656a46
https://doi.org/10.1007/s10822-017-0025-6
https://doi.org/10.1007/s10822-017-0025-6
Publikováno v:
FEBS Open Bio
Understanding and identifying the receptor subtype selectivity of a ligand is an important issue in the field of drug discovery. Using a combination of classical molecular mechanics and quantum mechanical calculations, this report assesses the recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e0c6c61ab9bdd362655e1ff6917f451
https://doi.org/10.1002/2211-5463.12188
https://doi.org/10.1002/2211-5463.12188
Autor:
Mari Chiyoya, Tadaatsu Imaizumi, Kazuhiko Seya, Ken-Ichi Furukawa, Xu Liu, Zaiqiang Yu, Wei Yang, Kazuyuki Daitoku, Ikuo Fukuda, Shigeru Motomura, Motonori Tsuji
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 372(3)
Recently, we confirmed that in human aortic valve interstitial cells (HAVICs) isolated from patients with aortic valve stenosis (AVS), calcification is induced in high inorganic phosphate (high-Pi) medium by warfarin (WFN). Because WFN is known as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6bd6021a3d753e40467311fa2180736
https://pubmed.ncbi.nlm.nih.gov/32571893
https://pubmed.ncbi.nlm.nih.gov/32571893
Autor:
Motonori Tsuji
Publikováno v:
Journal of Molecular Graphics and Modelling. 62:262-275
We successfully simulated receptor-ligand complex holo-form formation using the human retinoid X receptor-α ligand-binding domain (LBD) and its natural ligand, 9-cis retinoic acid. The success of this simulation was strongly dependent on the finding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb18b3b0c05452d6c5fc73281a2c4a9
https://doi.org/10.1016/j.jmgm.2015.10.002
https://doi.org/10.1016/j.jmgm.2015.10.002