Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Motonobu Kato"'
Autor:
Naotaka Izumiyama-Shimomura, Akio Ishii, Motoji Sawabe, Hiroshi Kishimoto, Mitsuo Oshimura, Kenichi Nakamura, Kaiyo Takubo, Motonobu Kato, Naoshi Ishikawa, Mutsunori Fujiwara, Tomio Arai
Publikováno v:
Experimental Gerontology. 42:944-950
Many studies have demonstrated the association between telomere length in mitotic cells and carcinogenesis and mortality, but little attention has been focused on post-mitotic cells and human life expectancy. We assessed the relationship between telo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1280b24a4096d05faa99a91dcdb58abc
https://doi.org/10.1016/j.exger.2007.05.003
https://doi.org/10.1016/j.exger.2007.05.003
Autor:
Kei Nakachi, Motonobu Kato, Kenichi Nakamura, Yukitoshi Aoyagi, Eiju Tsuchiya, Tomio Arai, Mutsunori Fujiwara, Mitsuo Oshimura, Yasuhito Kobayashi, Motoji Sawabe, Koji Sasajima, Naotaka Izumiyama-Shimomura, Kaiyo Takubo
Publikováno v:
Journal of Investigative Dermatology. 119:1014-1019
We investigated progressive telomere shortening in normal human epidermis and lingual epithelium during aging, and attempted, in particular, to ascertain whether the telomere shortening that accompanies aging occurs at the same rate in different tiss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa620f078023b4bfe076d1aa666dbe50
https://doi.org/10.1046/j.1523-1747.2002.19523.x
https://doi.org/10.1046/j.1523-1747.2002.19523.x
Autor:
Motoji Sawabe, Eiki Furugori, Koji Sasajima, Naotaka Izumiyama, Kenichi Nakamura, Tomio Arai, Mutsunori Fujiwara, Mitsuo Oshimura, Yukiyoshi Esaki, Kaiyo Takubo, Motonobu Kato, Ken-ichi Mafune, Makoto Kammori
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 55:B533-B536
Progressive telomere shortening with aging was studied in the normal liver tissue of 94 human subjects aged between 0 and 101 years old to determine the rate of telomere loss in 1 year. Telomere length demonstrated accelerated shortening with reducti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6eae513a2ba5037a7f8e4c82d4317f4
https://doi.org/10.1093/gerona/55.11.b533
https://doi.org/10.1093/gerona/55.11.b533
Autor:
Tamiko Takemura, Mitsuru Noji, Mitsuo Oshimura, Ryo Masuda, Yoshiaki Furuhata, Masaru Oritsu, Mutsunori Fujiwara, Motonobu Kato, Isao Okayasu, Isao Tanaka
Publikováno v:
Modern Pathology. 13:723-729
Telomerase activity was examined by the telomeric repeat amplification protocol assay in 25 cases of lung adenocarcinoma, in relation to cancer cell differentiation, proliferation, and chromosome alterations. Telomerase activity, chromosome alteratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::804f257df4c822d71ec233751bc754c2
https://doi.org/10.1038/modpathol.3880125
https://doi.org/10.1038/modpathol.3880125
Autor:
Toji Osakabe, Isao Okayasu, Mitsuo Oshimura, Mutsunori Fujiwara, Hiroki Fukuda, Motonobu Kato
Publikováno v:
Japanese Journal of Cancer Research : Gann
Telomerase activity was examined by telomeric repeat amplification protocol assay in thyroid disease states, including adenomas and carcinomas, and correlated with clinicopathological features. Of a total of 26 papillary carcinomas, 16 cases (61.5%)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21d88981ab7ede8aa9ecdbe4f4ce671b
https://doi.org/10.1111/j.1349-7006.1997.tb00316.x
https://doi.org/10.1111/j.1349-7006.1997.tb00316.x
Autor:
Yoichi Tanaka, Kaiyo Takubo, Naotaka Izumiyama, Masao Miyashita, Kenichi Nakamura, Koji Sasajima, Mitsuo Oshimura, Motonobu Kato, Ken-ichi Mafune
Publikováno v:
Journal of Surgical Oncology. 66:88-92
Background and Objectives Telomerase is a ribonucleoprotein that synthesizes telomeric DNA. Immortalized and carcinoma cells show no loss of telomere length during cell division. Telomerase activity has been demonstrated in carcinomas of various orga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::819a74447e3cb040c61733e9bf36e950
https://doi.org/10.1002/(sici)1096-9098(199710)66:2<88::aid-jso3>3.0.co
https://doi.org/10.1002/(sici)1096-9098(199710)66:2<88::aid-jso3>3.0.co
Publikováno v:
Agricultural and Biological Chemistry. 55:1823-1829
The effect of hydrophobic particles on foam stability was quantitatively evaluated by the parameters in the capillary model. Polystyrene particles were dispersed into an ovalbumin solution, foam then being produced by introducing air into the ovalbum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dae77cbe84b25a3c36ed904203df65e5
https://doi.org/10.1080/00021369.1991.10870871
https://doi.org/10.1080/00021369.1991.10870871
Autor:
Mitsuo Oshimura, Hiroshi Kishimoto, Kenichi Nakamura, Mutsunori Fujiwara, Motoji Sawabe, Motonobu Kato, Tomio Arai, Naoko Honma, Junko Aida, Akio Ishii, Fujio Takeuchi, Naotaka Izumiyama, Kaiyo Takubo
Publikováno v:
Experimental gerontology. 41(9)
We have conducted systematic studies to measure telomere length in human tissues of all types. Progressive telomere shortening with aging was studied in specimens of normal pancreas obtained at autopsy from 69 subjects aged 0 to 100 yr, and age-relat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61cd690f82ab075b25c9aa442dd73aad
https://pubmed.ncbi.nlm.nih.gov/16860503
https://pubmed.ncbi.nlm.nih.gov/16860503
Autor:
Mitsuo Oshimura, Naoko Honma, Naotaka Izumiyama-Shimomura, Motoji Sawabe, Tomio Arai, Kenichi Nakamura, Motonobu Kato, Kaiyo Takubo
Publikováno v:
Experimental gerontology. 37(4)
Background. A great deal of attention has been focused on telomeres in relation to cellular aging, immortality, and cancer. However, there is no simple link between telomeres and tissue turnover. We recently proposed a hypothesis that telomere shorte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ce02e96256837a96153223e78ac9a95
https://pubmed.ncbi.nlm.nih.gov/11830355
https://pubmed.ncbi.nlm.nih.gov/11830355
Autor:
Koji Sasajima, Isao Okayasu, Yukiyoshi Esaki, Kaiyo Takubo, Tomio Arai, Eiki Furugori, Mitsuo Oshimura, Mutsunori Fujiwara, Makoto Kammori, Kenichi Nakamura, Ken-ichi Mafune, Motoji Sawabe, Motonobu Kato
Publikováno v:
Cancer letters. 158(2)
The hypothesis that telomeres in colorectal cancer cells exhibit age-related shortening, as in normal cells of the colorectal epithelium, was tested with samples of non-cancerous mucosa and cancer tissue from 124 patients (aged 29-97 years). Shorteni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::614da22f717d22ec88c94dc56fc0e5ff
https://pubmed.ncbi.nlm.nih.gov/10960768
https://pubmed.ncbi.nlm.nih.gov/10960768