Zobrazeno 1 - 10
of 175
pro vyhledávání: '"Motonari, Uesugi"'
Autor:
Toshiki Ochiai, Tensei Inukai, Manato Akiyama, Kairi Furui, Masahito Ohue, Nobuaki Matsumori, Shinsuke Inuki, Motonari Uesugi, Toshiaki Sunazuka, Kazuya Kikuchi, Hideaki Kakeya, Yasubumi Sakakibara
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract The structural diversity of chemical libraries, which are systematic collections of compounds that have potential to bind to biomolecules, can be represented by chemical latent space. A chemical latent space is a projection of a compound str
Externí odkaz:
https://doaj.org/article/e5457904f4f54e489f843f4e0261fb18
Autor:
Soo-Yeon Hwang, Seojeong Park, Hyunji Jo, Seung Hee Seo, Kyung-Hwa Jeon, Seojeong Kim, Ah-Reum Jung, Chanju Song, Misun Ahn, Soo Yeon Kwak, Hwa-Jong Lee, Motonari Uesugi, Younghwa Na, Youngjoo Kwon
Publikováno v:
Journal of Advanced Research, Vol 47, Iss , Pp 173-187 (2023)
Introduction: HER2 overexpression induces cancer aggression and frequent recurrences in many solid tumors. Because HER2 overproduction is generally followed by gene amplification, inhibition of protein–protein interaction (PPI) between transcriptio
Externí odkaz:
https://doaj.org/article/c514c7b5d10c489d80d09349a306cdd7
Autor:
Satoshi Kawamura, Yuki Matsushita, Shigeyuki Kurosaki, Mizuki Tange, Naoto Fujiwara, Yuki Hayata, Yoku Hayakawa, Nobumi Suzuki, Masahiro Hata, Mayo Tsuboi, Takahiro Kishikawa, Hiroto Kinoshita, Takuma Nakatsuka, Masaya Sato, Yotaro Kudo, Yujin Hoshida, Atsushi Umemura, Akiko Eguchi, Tsuneo Ikenoue, Yoshihiro Hirata, Motonari Uesugi, Ryosuke Tateishi, Keisuke Tateishi, Mitsuhiro Fujishiro, Kazuhiko Koike, Hayato Nakagawa
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 11 (2022)
Enhanced de novo lipogenesis mediated by sterol regulatory element–binding proteins (SREBPs) is thought to be involved in nonalcoholic steatohepatitis (NASH) pathogenesis. In this study, we assessed the impact of SREBP inhibition on NASH and liver
Externí odkaz:
https://doaj.org/article/ed503c19945242ac8be07a0dfec98388
Autor:
Fumihiro Kawagoe, Kaori Yasuda, Sayuri Mototani, Toru Sugiyama, Motonari Uesugi, Toshiyuki Sakaki, Atsushi Kittaka
Publikováno v:
ACS Omega, Vol 4, Iss 6, Pp 11332-11337 (2019)
Externí odkaz:
https://doaj.org/article/2c9112394dd8460db46e56762c130f84
Autor:
Gonzalo Perez-Siles, Anthony Cutrupi, Melina Ellis, Jakob Kuriakose, Sharon La Fontaine, Di Mao, Motonari Uesugi, Reinaldo I. Takata, Carlos E. Speck-Martins, Garth Nicholson, Marina L. Kennerson, Annemieke Aartsma-Rus, James Dowling, Maaike van Putten
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 2 (2020)
ATP7A encodes a copper-transporting P-type ATPase and is one of 23 genes in which mutations produce distal hereditary motor neuropathy (dHMN), a group of diseases characterized by length-dependent axonal degeneration of motor neurons. We have generat
Externí odkaz:
https://doaj.org/article/96cf025b67e84cd9944cad361424728a
Autor:
Kohei Toh, Kosuke Nishio, Reiko Nakagawa, Syusuke Egoshi, Masahiro Abo, Amelie Perron, Shin-ichi Sato, Naoki Okumura, Noriko Koizumi, Kosuke Dodo, Mikiko Sodeoka, Motonari Uesugi
Publikováno v:
Journal of the American Chemical Society. 144:20171-20176
Visible light, particularly in the blue region of the spectrum, can cause cell dysfunction through the generation of singlet oxygen, contributing to cellular aging and age-related pathologies. Although photooxidation of nucleic acids, lipids, and ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5e8d8ee74a276a991a55ca22c49d5d8
https://doi.org/10.1021/jacs.2c07180
https://doi.org/10.1021/jacs.2c07180
Autor:
Tatsuki Ogasawara, Satomi Okano, Hajime Ichimura, Shin Kadota, Yuki Tanaka, Itsunari Minami, Motonari Uesugi, Yuko Wada, Naoto Saito, Kenji Okada, Koichiro Kuwahara, Yuji Shiba
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract Pluripotent stem cell-derived cardiomyocytes show great promise in regenerating the heart after myocardial infarction; however, several uncertainties exist that must be addressed before clinical trials. One practical issue is graft survival
Externí odkaz:
https://doaj.org/article/93fb020c748746f585e41a522d5a3a4e
Autor:
Kosuke Nishio, Kohei Toh, Amelie Perron, Masato Goto, Masahiro Abo, Yuichi Shimakawa, Motonari Uesugi
Publikováno v:
Journal of the American Chemical Society. 144:16720-16725
Melanin is an organic material biosynthesized from tyrosine in pigment-producing cells. The present study reports a simple method to generate tailored functional materials in mammalian cells by chemically fabricating intracellular melanin. Our approa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1befd4c1b20032ebca3799101f5c84d
https://doi.org/10.1021/jacs.2c06555
https://doi.org/10.1021/jacs.2c06555
Autor:
Toshiki Ochiai, Tensei Inukai, Manato Akiyama, Kairi Furui, Masahito Ohue, Nobuaki Matsumori, Shinsuke Inuki, Motonari Uesugi, Toshiaki Sunazuka, Kazuya Kikuchi, Hideaki Kakeya, Yasubumi Sakakibara
The structural diversity of chemical libraries, which are systematic collections of compounds that have potential to bind to biomolecules, can be represented by chemical latent space. A chemical latent space is a projection of a compound structure in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8c168523f29e345bc2c613fa98e8dfa
https://doi.org/10.26434/chemrxiv-2023-pjl0w-v2
https://doi.org/10.26434/chemrxiv-2023-pjl0w-v2
Autor:
Toshiki Ochiai, Tensei Inukai, Manato Akiyama, Kairi Furui, Masahito Ohue, Nobuaki Matsumori, Shinsuke Inuki, Motonari Uesugi, Toshiaki Sunazuka, Kazuya Kikuchi, Hideaki Kakeya, Yasubumi Sakakibara
The structural diversity of chemical libraries, which are systematic collections of compounds that have potential to bind to biomolecules, can be represented by chemical latent space. A chemical latent space is a projection of a compound structure in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98430c3302a7f38e0e939eae4420d49e
https://doi.org/10.26434/chemrxiv-2023-pjl0w
https://doi.org/10.26434/chemrxiv-2023-pjl0w