Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Motonao, Nakamura"'
Autor:
Sazanami Mori, Natsuki Nakamura, Ayane Fuchigami, Satoshi Yoshimoto, Moe Sakakibara, Toshiyuki Ozawa, Junken Aoki, Asuka Inoue, Hayakazu Sumida, Hideya Ando, Motonao Nakamura
Publikováno v:
FASEB BioAdvances, Vol 6, Iss 10, Pp 424-441 (2024)
Abstract Bitter taste receptors (TAS2Rs) are not only expressed in the oral cavity but also in skin. Extraoral TAS2Rs are thought to be involved in non‐taste perception and tissue‐specific functions. Keratinocytes that express TAS2Rs in the skin
Externí odkaz:
https://doaj.org/article/87f2088083af4c1389595ee070e7630c
Autor:
Moe Sakakibara, Hayakazu Sumida, Keisuke Yanagida, Sosuke Miyasato, Motonao Nakamura, Shinichi Sato
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Bitter taste receptors (T2Rs) are G protein-coupled receptors involved in the perception of bitter taste on the tongue. In humans, T2Rs have been found in several sites outside the oral cavity. Although T2R38 has been reported to be expresse
Externí odkaz:
https://doaj.org/article/54fbfc65d8fc4b8493bb8e840f70e4c8
Autor:
Miho Asahara, Nobuko Ito, Yoko Hoshino, Takaharu Sasaki, Takehiko Yokomizo, Motonao Nakamura, Takao Shimizu, Yoshitsugu Yamada
Publikováno v:
PLoS ONE, Vol 17, Iss 10 (2022)
Leukotriene B4 (LTB4) is a potent lipid mediator involved in the recruitment and activation of neutrophils, which is an important feature of tissue injury and inflammation. The biological effects of LTB4 are primarily mediated through the high-affini
Externí odkaz:
https://doaj.org/article/72a6cc41bfe149d28111edbfb2949b3d
Autor:
Takehiko Yokomizo, Mohib Uddin, Takao Shimizu, Charles N. Serhan, G. Enrico Rovati, Joshua Rokach, William Powell, Motonao Nakamura, Douglas W. P. Hay, Jilly F. Evans, Jeffrey Drazen, Gordon Dent, Sven-Erik Dahlén, Nan Chiang, Charles Brink, Magnus Bäck
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
The leukotriene receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Leukotriene Receptors [35, 38]) are activated by the endogenous ligands leukotrienes (LT), synthesized from lipoxygenase metabolism of arachidonic acid. The human BLT1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7211bbfdfb0c8ea41a8e35d28bc40362
https://doi.org/10.2218/gtopdb/f35/2023.1
https://doi.org/10.2218/gtopdb/f35/2023.1
Autor:
Sosuke, Miyasato, Kurumi, Iwata, Reika, Mura, Shou, Nakamura, Keisuke, Yanagida, Hideo, Shindou, Yosuke, Nagata, Masahiro, Kawahara, Satoshi, Yamaguchi, Junken, Aoki, Asuka, Inoue, Teruyuki, Nagamune, Takao, Shimizu, Motonao, Nakamura
Publikováno v:
The FASEB Journal. 37
The G protein-coupled receptors, GPR43 (free fatty acid receptor 2, FFA2) and GPR41 (free fatty acid receptor 3, FFA3), are activated by short-chain fatty acids produced under various conditions, including microbial fermentation of carbohydrates. Pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd32c7ce2716d491b2e80e066477e04f
https://doi.org/10.1096/fj.202201591r
https://doi.org/10.1096/fj.202201591r
Autor:
Motonao, Nakamura, Takao, Shimizu
Publikováno v:
Biochemical pharmacology. 203
Leukotriene B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5d6d80c2e34a020825e76a7b1a5aad98
https://pubmed.ncbi.nlm.nih.gov/35850310
https://pubmed.ncbi.nlm.nih.gov/35850310
Autor:
Motonao Nakamura, Takehiko Yokomizo
Publikováno v:
Encyclopedia of Molecular Pharmacology ISBN: 9783030215736
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58489ae6668950ed1ae3ecb4f5b2acf9
https://doi.org/10.1007/978-3-030-21573-6_87-1
https://doi.org/10.1007/978-3-030-21573-6_87-1
Publikováno v:
Journal of Clinical Investigation. 128:2691-2701
Leukotrienes, a class of arachidonic acid–derived bioactive molecules, are known as mediators of allergic and inflammatory reactions and considered to be important drug targets. Although an inhibitor of leukotriene biosynthesis and antagonists of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edb47910dd78deb485e14c8c1f1a4a6c
https://doi.org/10.1172/jci97946
https://doi.org/10.1172/jci97946
Autor:
Motonao Nakamura, Keitaro Yamashita, Yoshiaki Kawano, Kunio Hirata, Takao Shimizu, Toshiaki Okuno, Masakatsu Hato, Masashi Miyano, Takehiko Yokomizo, Masaki Yamamoto, Shigeyuki Yokoyama, Tetsuya Hori
Publikováno v:
Nature Chemical Biology. 14:262-269
Most G-protein-coupled receptors (GPCRs) are stabilized in common in the inactive state by the formation of the sodium ion-centered water cluster with the conserved Asp2.50 inside the seven-transmembrane domain. We determined the crystal structure of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d17ec6a6686d7103b61941307d7b5ac8
https://doi.org/10.1038/nchembio.2547
https://doi.org/10.1038/nchembio.2547