Zobrazeno 1 - 10
of 639
pro vyhledávání: '"Motomu Kanai"'
Autor:
Masahiro Furuta, Suguru Arii, Hiroki Umeda, Ryota Matsukawa, Katsuyuki Shizu, Hironori Kaji, Shigehiro A. Kawashima, Yukiko Hori, Taisuke Tomita, Youhei Sohma, Harunobu Mitsunuma, Motomu Kanai
Publikováno v:
Advanced Science, Vol 11, Iss 26, Pp n/a-n/a (2024)
Abstract Aberrant aggregates of amyloid‐β (Aβ) and tau protein (tau), called amyloid, are related to the etiology of Alzheimer disease (AD). Reducing amyloid levels in AD patients is a potentially effective approach to the treatment of AD. The se
Externí odkaz:
https://doaj.org/article/3a27e950c08646478461fff6e10930c9
Autor:
Akiko Fujimura, Hisashi Ishida, Tamiko Nozaki, Shuhei Terada, Yuto Azumaya, Tadashi Ishiguro, Yugo R. Kamimura, Tomoya Kujirai, Hitoshi Kurumizaka, Hidetoshi Kono, Kenzo Yamatsugu, Shigehiro A. Kawashima, Motomu Kanai
Publikováno v:
ACS Central Science, Vol 9, Iss 11, Pp 2115-2128 (2023)
Externí odkaz:
https://doaj.org/article/b35bf482716e4c2ab9429ea65fa36663
Autor:
Toshifumi Tatsumi, Koki Sasamoto, Takuya Matsumoto, Ryo Hirano, Kazuki Oikawa, Masato Nakano, Masaru Yoshida, Kounosuke Oisaki, Motomu Kanai
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-10 (2023)
Abstract Accessible drug modalities have continued to increase in number in recent years. Peptides play a central role as pharmaceuticals and biomaterials in these new drug modalities. Although traditional peptide synthesis using chain-elongation fro
Externí odkaz:
https://doaj.org/article/dd52ba5874754e7192051673b3bd8702
Autor:
Misuzu Habazaki, Shinsuke Mizumoto, Hidetoshi Kajino, Tomoya Kujirai, Hitoshi Kurumizaka, Shigehiro A. Kawashima, Kenzo Yamatsugu, Motomu Kanai
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Life emerges from a network of biomolecules and chemical reactions catalyzed by enzymes. As enzyme abnormalities are often connected to various diseases, a chemical catalyst promoting physiologically important intracellular reactions in plac
Externí odkaz:
https://doaj.org/article/8156d1d6d4ed4143bdbccaca68aeba30
Autor:
Haruka Oda, Yuko Sato, Shigehiro A. Kawashima, Yusuke Fujiwara, Máté Pálfy, Edlyn Wu, Nadine L. Vastenhouw, Motomu Kanai, Hiroshi Kimura
Publikováno v:
Biology Open, Vol 12, Iss 5 (2023)
Externí odkaz:
https://doaj.org/article/bcc5762fa3414d49a4e5ace8d7b9abf7
Publikováno v:
Neuroscience Insights, Vol 17 (2022)
Alzheimer’s disease (AD) is characterized by the aggregation and deposition of 2 amyloid proteins: amyloid β peptide (Aβ) and tau protein. Immunotherapies using anti-Aβ antibodies to promote the clearance of aggregated Aβ have recently been hig
Externí odkaz:
https://doaj.org/article/e8db6bf7234449d4a4589e2a3286ec26
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Alzheimer disease (AD) is associated with the aggregation of two amyloid proteins: tau and amyloid-β (Aβ). The results of immunotherapies have shown that enhancing the clearance and suppressing the aggregation of these two proteins are effective th
Externí odkaz:
https://doaj.org/article/e983fcaa52c349e3a82d4322edc9fde9
Autor:
Hongyu Chen, Shigeru Yamaguchi, Yuya Morita, Hiroyasu Nakao, Xiangning Zhai, Yohei Shimizu, Harunobu Mitsunuma, Motomu Kanai
Publikováno v:
Cell Reports Physical Science, Vol 2, Iss 12, Pp 100679- (2021)
Summary: Asymmetric catalysis enabling divergent control of multiple stereocenters remains challenging in synthetic organic chemistry. Although machine-learning-based optimization of molecular catalysis is a rapidly growing research field, the use of
Externí odkaz:
https://doaj.org/article/85738eb604464b5898403b59bb163271
Autor:
Hirotada Tajiri, Takehito Uruno, Takahiro Shirai, Daisuke Takaya, Shigeki Matsunaga, Daiki Setoyama, Mayuki Watanabe, Mutsuko Kukimoto-Niino, Kounosuke Oisaki, Miho Ushijima, Fumiyuki Sanematsu, Teruki Honma, Takaho Terada, Eiji Oki, Senji Shirasawa, Yoshihiko Maehara, Dongchon Kang, Jean-François Côté, Shigeyuki Yokoyama, Motomu Kanai, Yoshinori Fukui
Publikováno v:
Cell Reports, Vol 19, Iss 5, Pp 969-980 (2017)
Summary: Oncogenic Ras plays a key role in cancer initiation but also contributes to malignant phenotypes by stimulating nutrient uptake and promoting invasive migration. Because these latter cellular responses require Rac-mediated remodeling of the
Externí odkaz:
https://doaj.org/article/4cc761b3ff17413a8dbd9ef0c48be572
Publikováno v:
ACS Central Science, Vol 2, Iss 1, Pp 21-26 (2016)
Externí odkaz:
https://doaj.org/article/d82d4f83d76a4c1c9bfe8325cee75ccc