Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Motomu, Kuroki"'
Publikováno v:
International Journal of Cancer. 135:2697-2710
Conventional photodynamic therapy (PDT) for cancer is limited by the insufficient efficacy and specificity of photosensitizers. We herein describe a highly effective and selective tumor-targeted PDT using a near-infrared (NIR) photosensitizer, IRDye7
Publikováno v:
Chemotherapy. 58:110-117
Background: Carcinoembryonic antigen (CEA) is frequently overexpressed in various types of human cancers and is associated with cell adhesion. There are three possible mechanisms of cancer therapy that employ anti-CEA antibody (Ab): Ab-dependent cell
Recombinant Human Monoclonal IgA Antibody Against CEA to Recruit Neutrophils to CEA-Expressing Cells
Autor:
Lin Wang, Tetsushi Kinugasa, Noboru Takami, Qun Huo, Toshihiro Tanaka, Masahide Kuroki, Motomu Kuroki, Jun Zhao, Hirotomo Shibaguchi
Publikováno v:
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics. 17:217-222
IgA is able to trigger antibody-dependent cellular cytotoxicity (ADCC) by recruiting neutrophils expressing the Fc receptor for the CHalpha chain. We herein describe the preparation of a human recombinant anti-CEA IgA antibody to kill carcinoembryoni
Autor:
Ken Hachimine, Masahide Kuroki, Yoshinori Nakae, Motomu Kuroki, Isao Sakata, Hirotomo Shibaguchi, Tetsushi Kinugasa, Yuichi Yamashita, Takayuki Shirakusa, Ryuji Asano, Hiromi Yamada
Publikováno v:
Cancer Science. 98:916-920
To improve the efficacy of sonodynamic therapy of cancer using photosensitizers, we developed a novel porphyrin derivative designated DCPH-P-Na(I) and investigated its photochemical characteristics and sonotoxicity on tumor cells. DCPH-P-Na(I) exhibi
Publikováno v:
BioMed Research International, Vol 2015 (2015)
In the paper entitled “Molecular Characterization of a Fully Human Chimeric T-Cell Antigen Receptor for Tumor-Associated Antigen EpCAM,” there was an error in the amino acid/nucleotide sequences in Figure 2. Actually, the sequences were not for a
Autor:
Naoki Watanabe, Hirofumi Hamada, Masahide Kuroki, Jianhua Huang, Sachie Hirai, Kei Tomihara, Toshihiro Tanaka, Motomu Kuroki, Kazunori Kato
Publikováno v:
Clinical Cancer Research. 12:3803-3813
Purpose: A major problem when using the adenoviral vectors for gene therapy applications is thought to be related to low transduction efficiency in cancer cells or to side effects in normal cells. There is an urgent requirement to improve the specifi
Publikováno v:
Japanese Journal of Complementary and Alternative Medicine. 2:15-21
がんの免疫療法は,大きくワクチン療法と抗体療法に分けられる.ワクチン療法が患者自身の細胞性免疫賦活を目指す能動免疫療法であるのに対し,抗体療法は異種動物の液性免疫(抗
Autor:
Hiromi Yamada, Jitian Zhang, Ken Hachimine, Masahide Kuroki, Yumiko Hirose, Adel Badran, Motomu Kuroki, Hirotomo Shibaguchi
Publikováno v:
Nihon Kikan Shokudoka Gakkai Kaiho. 55:55-64
Publikováno v:
Radiology. 229:423-428
To determine if commercially available echo-enhanced microbubble contrast agents could be used to increase gene transfection efficiency by means of relatively low-intensity ultrasound-mediated microbubble destruction in skeletal muscles.Three types o
Autor:
Hirotomo Shibaguchi, Hironori Abe, Takayuki Imakiire, Isao Ishida, Yumiko Hirose, Yuichi Yamashita, Takayuki Shirakusa, Yasushi Yamauchi, Hiromi Yamada, Masahide Kuroki, Aruto Ueno, Motomu Kuroki
Publikováno v:
International Journal of Cancer. 108:564-570
We generated fully human mAbs (HmAbs) to carcinoembryonic antigen (CEA) using the KM mouse, which carries a human chromosome 14 fragment containing the entire Ig H chain loci and human kappa L chain segments in the mouse genome. Forty-six hybridoma c