Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Motomichi Kono"'
Autor:
Masaji Kasai, Motomichi Kono
Publikováno v:
Synlett. 1992:778-790
The studies on the chemistry of mitomycins are described : i) identification and structural elucidation of mitomycins D, E, F, G, I, J, K, L, M, albomitomycin A, and isomitomycin A from the fermentation broth; ii) derivation of mitomycins structurall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::675e4c1204adc24f7c277424162478d1
https://doi.org/10.1055/s-1992-21490
https://doi.org/10.1055/s-1992-21490
Autor:
Koji Yamada, Eiko Ohishi, Toshiaki Kumazawa, Shigeki Matsumiya, Shiro Shirakura, Masashi Yanase, Motomichi Kono
Publikováno v:
Chemical and Pharmaceutical Bulletin. 44:222-225
In a previous paper, we reported a novel inhibitor of acyl-CoA: cholesterol acyltransferase (ACAT), 2-bromo-N-(2,6-diisopropylphenyl)-6,11- dihydrodibenz[b,e]oxepin-11-carboxamide (1). In this work, we prepared both enantiomers and tested them for ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0986b3c2d79c4dbc4b98e852791d5ec4
https://doi.org/10.1248/cpb.44.222
https://doi.org/10.1248/cpb.44.222
Autor:
Katsushige Gomi, Hitoshi Arai, Motomichi Kono, Tadashi Ashizawa, Masaji Kasai, Hiromitsu Saito
Publikováno v:
Journal of Medicinal Chemistry. 38:3025-3033
A series of 6-demethylmitomycins and 6-demethyl-6-halomitomycins having various mitomycin skeletons were synthesized, taking into account the electronic effect toward the quinone moiety and the partition coefficients. Treatment of enones 15 and 16 wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3525a8d9a120045814f29df4d1d31b3c
https://doi.org/10.1021/jm00016a005
https://doi.org/10.1021/jm00016a005
Autor:
Akio Ishii, Nobuyuki Yoda, Shunji Ichikawa, Yoshikazu Miwa, Tohru Yasuzawa, Fumio Suzuki, Hiroaki Hayashi, Motomichi Kono, Ichiro Miki
Publikováno v:
Journal of Medicinal Chemistry. 36:617-626
A series of 4-hydroxy-3-quinolinecarboxylic acid derivatives (6) and 4-hydroxy-2-oxo-1,2-dihydro-3-quinolinecarboxylic acid derivatives (7) were designed and synthesized as 5-HT3 receptor antagonists. Molecular modeling studies suggested that the 3-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad622dbc92c48b288321687912436a90
https://doi.org/10.1021/jm00057a011
https://doi.org/10.1021/jm00057a011
Autor:
Katsushige Gomi, Motomichi Kono, Masaji Kasai, Hitoshi Arai, Makoto Inaba, Jeong-Hyung Lee, Masami Okabe, Takashi Tsuruo, Eiji Kobayashi
Publikováno v:
Cancer Chemotherapy and Pharmacology. 32:20-24
KW-2149, a new mitomycin C (MMC) derivative, inhibited the growth of murine P388 leukemia in vitro at 20-fold lower concentrations than those of MMC. KW-2149 was also effective in inhibiting the growth of MMC-resistant P388 (P388/MMC) cells. To eluci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::285adf062fded21eb1754544027f7b68
https://doi.org/10.1007/bf00685871
https://doi.org/10.1007/bf00685871
Autor:
Masaji Kasai, Motomichi Kono
Publikováno v:
ChemInform. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6857568cba10e23de38f1fd2cfbf1fc1
https://doi.org/10.1002/chin.199322327
https://doi.org/10.1002/chin.199322327
Publikováno v:
ChemInform. 24
After inspection of the X-ray crystallographic analyses of mitomycin A (1a) and albomitomycin A (2), an efficient chemical conversion of 1a to isomitomycin A (3) via 2 was accomplished in 68% overall yield. First, 1a was converted to (8aS)-8a-bromoal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7af55f0601d327732abec1844ef8ced1
https://doi.org/10.1002/chin.199320276
https://doi.org/10.1002/chin.199320276
Autor:
Hiroaki Hayashi, I. Miki, Motomichi Kono, Y. Miwa, Akio Ishii, Nobuyuki Yoda, Fumio Suzuki, S. Ichikawa
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::568c112d63b58a0eb9b6befa3b1cae70
https://doi.org/10.1002/chin.199408209
https://doi.org/10.1002/chin.199408209
Autor:
Katsushige Gomi, Hitoshi Arai, Masaji Kasai, Yutaka Kanda, Makoto Morimoto, Motomichi Kono, Tadashi Ashizawa
Publikováno v:
ChemInform. 25
A series of 6-alkyl-6-demethylmitomycins (1-5) was synthesized and eva- luated for anticellular and antitumor activities. These novel compounds were prepared by Michael addition of various carbanion species to 6-de- methyl-7,7-(ethylenedioxy)-6,7-dih
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5021031fb44fe9eabbbc6f7983f93fcc
https://doi.org/10.1002/chin.199444223
https://doi.org/10.1002/chin.199444223
Autor:
Hitoshi Arai, Katsushige Gomi, Tadashi Ashizawa, Motomichi Kono, Makoto Morimoto, Yutaka Kanda, Masaji Kasai
Publikováno v:
ChemInform. 25
A series of C-6-substituted methyl mitomycins was synthesized and evaluated for anticellular and antitumor activities. These novel compounds were prepared by Michael addition of various alcohols or thiols to 6-demethyl-7,7-(ethylenedioxy)-6,7-dihydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f4e71f133431426bc60f2a402a0c2a6
https://doi.org/10.1002/chin.199444222
https://doi.org/10.1002/chin.199444222