Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Motomasa Tanaka"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Excitatory-inhibitory (E-I) imbalance has been shown to contribute to the pathogenesis of a wide range of neurodevelopmental disorders including autism spectrum disorders, epilepsy, and schizophrenia. GABA neurotransmission, the principal inhibitory
Externí odkaz:
https://doaj.org/article/8905461c1ed14815b16635a00f95b989
Autor:
Andrea Raspadori, Valentina Vignali, Anna Murello, Gabriele Giachin, Bruno Samorì, Motomasa Tanaka, Carlos Bustamante, Giampaolo Zuccheri, Giuseppe Legname
Publikováno v:
Biology, Vol 11, Iss 9, p 1358 (2022)
Prion diseases are neurodegenerative disorders characterized by the presence of oligomers and amyloid fibrils. These are the result of protein aggregation processes of the cellular prion protein (PrPC) into amyloidal forms denoted as prions or PrPSc.
Externí odkaz:
https://doaj.org/article/80e7947aa8524f1bb215b7d429c4d989
Autor:
Chien-Wen Chen, Motomasa Tanaka
Publikováno v:
Cell Reports, Vol 23, Iss 2, Pp 608-621 (2018)
Summary: In the ribosome complex, tRNA is a critical element of mRNA translation. A rich repertoire of cell regulation is hypothesized to occur during the recruitment of specific tRNAs in polypeptide formation. However, this basic question in nascent
Externí odkaz:
https://doaj.org/article/89b7b75966c74c96a18684cc5d101b2f
Publikováno v:
Biomolecules, Vol 9, Iss 11, p 680 (2019)
De novo protein synthesis by the ribosome and its multitude of co-factors must occur in a tightly regulated manner to ensure that the correct proteins are produced accurately at the right time and, in some cases, also in the proper location. With nov
Externí odkaz:
https://doaj.org/article/882fb54101384f228998c3af82e2c627
Autor:
Per Nilsson, Krishnapriya Loganathan, Misaki Sekiguchi, Yukio Matsuba, Kelvin Hui, Satoshi Tsubuki, Motomasa Tanaka, Nobuhisa Iwata, Takashi Saito, Takaomi C. Saido
Publikováno v:
Cell Reports, Vol 5, Iss 1, Pp 61-69 (2013)
Alzheimer’s disease (AD) is a neurodegenerative disease biochemically characterized by aberrant protein aggregation, including amyloid beta (Aβ) peptide accumulation. Protein aggregates in the cell are cleared by autophagy, a mechanism impaired in
Externí odkaz:
https://doaj.org/article/d0f37d878e9b41ad88e3270753afdfc7
Autor:
Ryo Endo, Yi-Kai Chen, John Burke, Noriko Takashima, Nayan Suryawanshi, Kelvin K. Hui, Tatsuhiko Miyazaki, Motomasa Tanaka
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Ribosome-associated quality control (RQC) pathway is responsible for degradation of nascent polypeptides in aberrantly stalled ribosomes, and its defects may lead to neurological diseases. However, the underlying molecular mechanism of how RQC dysfun
Autor:
Hanna Jaaro-Peled, Sunil Kumar, Dalton Hughes, Akiko Sumitomo, Sun-Hong Kim, Sandra Zoubovsky, Yuki Hirota-Tsuyada, Diana Zala, Julie Bruyere, Brittany M. Katz, Beverly Huang, Rafael Flores, Soumya Narayan, Zhipeng Hou, Aris N. Economides, Takatoshi Hikida, William C. Wetsel, Karl Deisseroth, Susumu Mori, Nicholas J. Brandon, Motomasa Tanaka, Koko Ishizuka, Miles D. Houslay, Frédéric Saudou, Kafui Dzirasa, Akira Sawa, Toshifumi Tomoda
Publikováno v:
Molecular Psychiatry. 27:1805-1815
Sensorimotor information processing underlies normal cognitive and behavioral traits and has classically been evaluated through prepulse inhibition (PPI) of a startle reflex. PPI is a behavioral dimension deregulated in several neurological and psych
Publikováno v:
IECON 2022 – 48th Annual Conference of the IEEE Industrial Electronics Society.
Publikováno v:
Seibutsu Butsuri. 60:236-240
Publikováno v:
Biol Psychiatry
Recent genetic approaches have demonstrated that genetic factors contribute to the pathologic origins of neuropsychiatric disorders. Nevertheless, the exact pathophysiological mechanism for most cases remains unclear. Recent studies have demonstrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b2c4fa692e9eb5d99e20d9e3645c08b
https://europepmc.org/articles/PMC8792182/
https://europepmc.org/articles/PMC8792182/