Zobrazeno 1 - 10
of 313
pro vyhledávání: '"Motomasa Kobayashi"'
Autor:
Yuji Sumii, Naoyuki Kotoku, Akinori Fukuda, Takashi Kawachi, Masayoshi Arai, Motomasa Kobayashi
Publikováno v:
Marine Drugs, Vol 13, Iss 12, Pp 7419-7432 (2015)
Oral dictyoceratin-C (1) and A (2), hypoxia-selective growth inhibitors, showed potent in vivo antitumor effects in mice subcutaneously inoculated with sarcoma S180 cells. Structurally modified analogs were synthesized to assess the structure–activ
Externí odkaz:
https://doaj.org/article/f8242298903e409b80bf8067d59277cd
Autor:
Takashi Kawachi, Shun Tanaka, Akinori Fukuda, Yuji Sumii, Andi Setiawan, Naoyuki Kotoku, Motomasa Kobayashi, Masayoshi Arai
Publikováno v:
Marine Drugs, Vol 17, Iss 3, p 163 (2019)
Hypoxia-adapted cancer cells in tumors contribute to the pathological progression of cancer. The marine spongean sesquiterpene phenols dictyoceratin-A (1) and -C (2) have been shown to induce hypoxia-selective growth inhibition in cultured cancer cel
Externí odkaz:
https://doaj.org/article/0a4a25132b2d40dd8b57ba9d903c6c0d
Publikováno v:
Marine Drugs, Vol 9, Iss 6, Pp 984-993 (2011)
A macrocyclic alkaloid, halicyclamine A, was re-discovered from an Indonesian marine sponge of Haliclona sp. 05A08 as an anti-dormant mycobacterial substance. To clarify action-mechanism of halicyclamine A, halicyclamine A-resistant strains were scre
Externí odkaz:
https://doaj.org/article/5bc8fcb8825948db821ab321a98f40cf
Publikováno v:
Marine Drugs, Vol 9, Iss 2, Pp 154-161 (2011)
We previously reported that smenospongine, a sesquiterpene aminoquinone isolated from the marine sponge Dactylospongia elegans, showed antiproliferative or cytotoxic activities on leukemia cells. In this study, we investigated the effect of smenospon
Externí odkaz:
https://doaj.org/article/7e94cff16ede4c2b8ff2b46f59408dc4
Publikováno v:
Marine Drugs, Vol 6, Iss 3, Pp 480-488 (2008)
Smenospongine, a sesquiterpene aminoquinone isolated from the marine sponge Dactylospongia elegans, was previously reported by us to induce erythroid differentiation and G1 phase arrest of K562 chronic myelogenous leukemia cells. In this study, we in
Externí odkaz:
https://doaj.org/article/9f5f4b66181f4d87ab79cc36075f98f0
Autor:
Naoyuki Kotoku, Shunichi Shibuya, Masaki Nogata, Aoi Ito, Aki Takeshima, Motomasa Kobayashi, Kanako Mizuno
Publikováno v:
Tetrahedron. 73:1342-1349
An improved method for synthesizing structurally simplified analogs of cortistatin A (1), a novel anti-angiogenic steroidal alkaloid from a marine sponge, was developed. In contrast to previous methods, step- and redox-economical synthesis was achiev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16380b1f0f69a2894bbc5a347f086737
https://doi.org/10.1016/j.tet.2017.01.042
https://doi.org/10.1016/j.tet.2017.01.042
Autor:
Masayoshi Arai, Osamu Muraoka, Naoyuki Kotoku, Ryosuke Ishida, Hirokazu Matsumoto, Kazunari Toda, Motomasa Kobayashi, Andi Setiawan
Publikováno v:
The Journal of Organic Chemistry. 82:1705-1718
Biakamides A-D, novel unusually unique polyketides, were isolated from an Indonesian marine sponge (Petrosaspongia sp.) with a constructed bioassay using PANC-1 human pancreatic cancer cells. Through detailed analyses of the one- and two-dimensional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b2dcf267d5578f267ea91793037b1f6
https://doi.org/10.1021/acs.joc.6b02948
https://doi.org/10.1021/acs.joc.6b02948
Autor:
Masayoshi Arai, Motomasa Kobayashi, Yuji Sumii, Akinori Fukuda, Shun Tanaka, Andi Setiawan, Takashi Kawachi, Naoyuki Kotoku
Publikováno v:
Marine Drugs, Vol 17, Iss 3, p 163 (2019)
Marine Drugs
Volume 17
Issue 3
Marine Drugs
Volume 17
Issue 3
Hypoxia-adapted cancer cells in tumors contribute to the pathological progression of cancer. The marine spongean sesquiterpene phenols dictyoceratin-A (1) and -C (2) have been shown to induce hypoxia-selective growth inhibition in cultured cancer cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8667a2abcc940b5916f21adaea0a39ad
http://www.mdpi.com/1660-3397/17/3/163
http://www.mdpi.com/1660-3397/17/3/163
Publikováno v:
Natural product communications. 12(4)
In the course of a search for anti-dormant mycobacterial substances from marine-derived microorganisms, viomellein (1) and xanthomegnin (2) were re- discovered from the active fraction of the culture of a marine-derived Aspergillus sp. together with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7190c7256adf686f0e125160fb79f1ba
https://pubmed.ncbi.nlm.nih.gov/30520600
https://pubmed.ncbi.nlm.nih.gov/30520600
Autor:
Hirokazu Matsumoto, Kentaro Kamiya, Tomoya Hisa, Andi Setiawan, Dayoung Shin, Masayoshi Arai, Motomasa Kobayashi, Naoyuki Kotoku
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 64:766-771
In the course of searching for selective growth inhibitors of the cancer cells adapted to nutrient starvation, a new 3-alkylpyridine alkaloid named N-methylniphatyne A (1) was isolated from an Indonesian marine sponge of Xestospongia sp. The chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d83b5d3283ce13c277d163056e05b43
https://doi.org/10.1248/cpb.c16-00118
https://doi.org/10.1248/cpb.c16-00118