Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Motoko YAMAMOTO"'
Autor:
Seiji Kuroda, Yoshitaka Miyagawa, Makoto Sukegawa, Taro Tomono, Motoko Yamamoto, Kumi Adachi, Gianluca Verlengia, William F. Goins, Justus B. Cohen, Joseph C. Glorioso, Takashi Okada
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 132-143 (2022)
Replication competent oncolytic herpes simplex virus (HSV) vectors have been used extensively to treat solid tumors with promising results. However, highly defective HSV vectors will be needed for applications that require sustained therapeutic gene
Externí odkaz:
https://doaj.org/article/cae94c94bb3947dbb4ea5e4059f6063d
Autor:
Noriko Miyake, Koichi Miyake, Atsushi Sakai, Motoko Yamamoto, Hidenori Suzuki, Takashi Shimada
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Metachromatic leukodystrophy (MLD) is a lysosomal storage disease caused by an arylsulfatase A (ARSA) deficiency and characterized by severe neurological symptoms resulting from demyelination within the central and peripheral nervous systems
Externí odkaz:
https://doaj.org/article/4dd8f9e3c6f542a4b4d9938ecef5e221
Autor:
Seiji Kuroda, Yoshitaka Miyagawa, Yuriko Sato, Motoko Yamamoto, Kumi Adachi, Hiromi Kinoh, William F. Goins, Justus B. Cohen, Joseph C. Glorioso, Nobuhiko Taniai, Hiroshi Yoshida, Takashi Okada
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 612-621 (2020)
Non-toxic herpes simplex virus (HSV) vectors can be generated by functional deletion of all immediate-early (IE) genes, providing a benign vehicle with potential for gene therapy. However, deletion of multiple IE genes raises manufacturing concerns a
Externí odkaz:
https://doaj.org/article/867c8bdaa11346fc9f704abb549b180d
Autor:
Taro Tomono, Yusuke Shiozawa, Motoko Yamamoto, Hironori Okada, Takashi Okada, Yoshitaka Miyagawa, Kumi Adachi
Publikováno v:
Gene Therapy. 29:449-457
The application of recombinant adeno-associated viruses (rAAVs) for gene therapy faces certain challenges, including genome packaging of non-vector sequences. Inverted terminal repeats (ITRs) flanking the rAAV genome, comprising three inverted repeat
Autor:
Takashi Okada, Yoshitaka Miyagawa, Justus B. Cohen, Joseph C. Glorioso, Yuriko Sato, Kumi Adachi, Seiji Kuroda, Hiroshi Yoshida, Hiromi Kinoh, Motoko Yamamoto, William F. Goins, Nobuhiko Taniai
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss, Pp 612-621 (2020)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Non-toxic herpes simplex virus (HSV) vectors can be generated by functional deletion of all immediate-early (IE) genes, providing a benign vehicle with potential for gene therapy. However, deletion of multiple IE genes raises manufacturing concerns a
Autor:
Takashi Shimada, Koichi Miyake, Atsushi Sakai, Noriko Miyake, Motoko Yamamoto, Hidenori Suzuki
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Metachromatic leukodystrophy (MLD) is a lysosomal storage disease caused by an arylsulfatase A (ASA) deficiency and characterized by severe neurological symptoms resulting from demyelination within the central and peripheral nervous systems. We inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29cbb681ced2326315a78b9814429dce
https://doi.org/10.21203/rs.3.rs-687914/v1
https://doi.org/10.21203/rs.3.rs-687914/v1
Autor:
Kumi, Adachi, Taro, Tomono, Hironori, Okada, Yusuke, Shiozawa, Motoko, Yamamoto, Yoshitaka, Miyagawa, Takashi, Okada
Publikováno v:
Gene therapy. 29(7-8)
The application of recombinant adeno-associated viruses (rAAVs) for gene therapy faces certain challenges, including genome packaging of non-vector sequences. Inverted terminal repeats (ITRs) flanking the rAAV genome, comprising three inverted repeat
Publikováno v:
Gene Therapy. 21:427-433
As both the immune system and the blood-brain barrier (BBB) are likely to be developmentally immature in the perinatal period, neonatal gene transfer may be useful for the treatment of lysosomal storage disease (LSD) with neurological involvements su
Autor:
Takashi Shimada, Akira Teramoto, Toshiyuki Kurai, Naotaka Iwamoto, Atsushi Watanabe, Motoko Yamamoto, Noriko Miyake
Publikováno v:
The Journal of Gene Medicine. 11:498-505
Background The success of gene therapy for inherited neurodegenerative diseases such as metachromatic leukodystrophy (MLD) depends on the development of efficient gene delivery throughout the brain guarded by the blood–brain barrier and achieves di
Publikováno v:
Molecular Therapy. 17(4):667-674
Hematopoietic cell gene therapy using retroviral vectors has achieved success in clinical trials. However, safety issues regarding vector insertional mutagenesis have emerged. In two different trials, vector insertion resulted in the transcriptional