Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Motoki Azuma"'
Publikováno v:
PLoS ONE, Vol 3, Iss 8, p e3070 (2008)
Haem is a prosthetic group for haem proteins, which play an essential role in oxygen transport, respiration, signal transduction, and detoxification. In haem biosynthesis, the haem precursor protoporphyrin IX (PP IX) must be accumulated into the mito
Externí odkaz:
https://doaj.org/article/bbb2c7af426d478cace38344c5a8c6f9
Autor:
Kenzo Nishiguchi, Motoki Azuma, Tasuku Tsukamoto, Ken-ichi Setsukinai, Yoshito Numata, Yousuke Okuno, Masatomo Rokushima, Hiroshi Takemoto, Hideki Maki, Kazuhiko Maekawa
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:7234-7239
Pseudomonas aeruginosa is one of the most common and clinically important pathogens because of its resistance to a wide variety of antibiotics. A number of treatments of P. aeruginosa have been developed, but there is still no definitive one. Antisen
Autor:
Takeshi Imai, Keisuke Miyazawa, Satoshi Sakamoto, Satoki Karasawa, Takeshi Kasama, Motoki Azuma, Yasuaki Kabe, Hiroshi Handa, Yuki Yamaguchi
Publikováno v:
Molecular Pharmacology. 83:613-620
Vitamin K2 (VK2, menaquinone) is known to have anticancer activity in vitro and in vivo. Although its effect is thought to be mediated, at least in part, by the induction of apoptosis, the underlying molecular mechanism remains elusive. Here, we iden
Autor:
Hiroshi Handa, Ken Kikuchi, Hiroyuki Nishiyama, Motoki Azuma, Toyoko Ochiai, Masao Kondo, Ayako Yasuma
Publikováno v:
J. Med. Microbiol.. 60(Pt.7):1038-1042
Erythrasma is a superficial skin disease caused by Gram-positive Corynebacterium species. Coral-red fluorescence under Wood's light, strongly suggestive of erythrasma, can be attributed to the presence of porphyrins. Fractionated porphyrin analysis i
Autor:
Takumi Ito, Makoto Suematsu, Yuichi Kobayashi, Marie Ikeda, Takeshi Imai, Satoshi Sakamoto, Motoki Azuma, Naoya Maekawa, Hiroshi Handa, Masaki Hiramoto, Michitaka Naitou, Hukum P. Acharya
Publikováno v:
Biomedical Chromatography. 25:466-471
Prostaglandin J₂ (PGJ₂) family have been reported to show various kinds of biological activities. Considerable progress has been made toward understanding the mechanism of adipogenesis, however, the mechanisms of other actions of PGJ₂ family re
Autor:
Makoto Suematsu, Hiroshi Handa, Motoki Azuma, Yasuaki Kabe, Yuki Kaneko, Atsushi Inoue, Kanako Kume, Yuki Yamaguchi, Takamitsu Hosoya, Masahiro Kizaki, Chikanori Kuramori
Publikováno v:
Biochem. Biophys. Res. Commun.. 379(2):519-525
Capsaicin is widely used as a food additive and as an analgesic agent. Besides its well-known role in nociception, which is mediated by vanilloid receptor 1 specifically expressed in dorsal root ganglion neurons, capsaicin has also been considered as
Autor:
Yosuke Iizumi, Michinaga Ogawa, Chihiro Sasakawa, Hiroshi Sagara, Peter G. Gillespie, Yasuaki Kabe, Hiroshi Handa, Kanako Kume, Motoki Azuma, Takeshi Nagai
Publikováno v:
Cell Host & Microbe. 2(6):383-392
SummaryEnteropathogenic Escherichia coli (EPEC) destroys intestinal microvilli and suppresses phagocytosis by injecting effectors into infected cells through a type III secretion system (TTSS). EspB, a component of the TTSS, is also injected into the
Autor:
Yasuaki Kabe, Masashi Ohmori, Hajime Watanabe, Yasunori Tsuboi, Ichiro Okura, Kazuya Shinouchi, Hiroshi Handa, Motoki Azuma, Satoshi Hirao
Publikováno v:
Journal of Biological Chemistry. 281:31729-31735
Heme (Fe-protoporphyrin IX), an endogenous porphyrin derivative, is an essential molecule in living aerobic organisms and plays a role in a variety of physiological processes such as oxygen transport, respiration, and signal transduction. For the bio
Autor:
Yuki Yamaguchi, Yasuaki Kabe, Motoki Azuma, Hiroshi Handa, Tadashi Wada, Yasunori Tsuboi, Hajime Watanabe, Yuji Ogura
Publikováno v:
Genes Cell. 11(4):373-381
TFII-I was initially identified as the general transcription factor that binds to initiator (Inr) elements in vitro. Subsequent studies have shown that TFII-I activates transcription of various genes either through Inr elements or through other upstr
Autor:
Takumi Ito, Satoshi Sakamoto, Shinichi Aizawa, Akihiro Nashimoto, Yosuke Iizumi, Eiji Yasumura, Yasuaki Kabe, Masafumi Suzuki, Hiroshi Handa, Masaki Hiramoto, Ryusuke Nabeshima, Yuki Yamaguchi, Daisuke Shima, Motoki Azuma, Kentaro Hotta, Akira Okada, Hideki Ando, Takeshi Imai, Kumiko Sakata-Sogawa, Hajime Watanabe, Makio Tokunaga
Publikováno v:
Molecular pharmacology. 83(5)
Vesnarinone is a synthetic quinolinone derivative used in the treatment of cardiac failure and cancer. It is also known to cause agranulocytosis as a side effect, which restricts its use, although the mechanism underlying agranulocytosis is not well