Výsledky vyhledávání - "Motoji Kogushi"

Oral administration of the thrombin receptor antagonist E5555 (atopaxar) attenuates intimal thickening following balloon injury in rats

Autor: Motoji Kogushi, Kenichi Chiba, Takashi Musha, Shuichi Suzuki, Akiharu Kajiwara, Ieharu Hishinuma, Tetsuya Kawahara, Tsutomu Kawata, Toshiyuki Matsuoka, Kimiyo Murakami, Akifumi Kimura, Hiroko Kuramochi

Publikováno v: European Journal of Pharmacology. 666:158-164

Thrombin is a powerful agonist for a variety of cellular responses including platelet aggregation and vascular smooth muscle cell (SMC) proliferation. These actions are mediated by a thrombin receptor known as protease-activated receptor-1 (PAR-1). R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::298dd42cf3f3923e39da5826e9872958
https://doi.org/10.1016/j.ejphar.2011.05.034

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Antibody to Thrombin Receptor Inhibits Neointimal Smooth Muscle Cell Accumulation Without Causing Inhibition of Platelet Aggregation or Altering Hemostatic Parameters After Angioplasty in Rat

Autor: Shinji Yoshitake, Toshie Yamada, Takashi Musha, Mamoru Yanagimachi, Motoji Kogushi, Hiroko Kobayashi, Takanori Kawamura, Osamu Ito, Hiroshi Tanaka, Masashi Ito, Masahiro Takada, Isao Saito, Fusayo Yoshida

Publikováno v: Circulation Research. 82:980-987

Abstract —An antibody was raised in rabbits against SFFLRNPSEDTFEQF peptide, which is an NH 2 -terminal peptide of the thrombin-cleaved rat thrombin receptor. In vitro, the antibody inhibited rat smooth muscle cell proliferation but had no effect o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53c6502797c4aff74d7561cd71d3bb15
https://doi.org/10.1161/01.res.82.9.980

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Anti-atherosclerotic effect of E5324, an inhibitor of acyl-CoA:cholesterol acyltransferase, in Watanabe heritable hyperlipidemic rabbits

Autor: Teiji Kimura, Hiroko Kobayashi, Shinji Yoshitake, Takao Saeki, Issei Ohtsuka, Toshie Yamada, Hiroshi Tanaka, Motoji Kogushi, Isao Saito, Hironobu Hiyoshi, Masahiro Takada, Mamoru Yanagimachi

Publikováno v: Atherosclerosis. 124:203-210

E5324, n-butyl-N'-[2-[3-(5-ethyl-4-phenyl-1H-imidazol-1-yl)propoxy]-6- methylphenyl]urea, a novel and potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), was evaluated for its anti-atherosclerotic and lipid-lowering effects in Watanabe h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db0afe73dd4a71581e49595cceb4deac
https://doi.org/10.1016/0021-9150(96)05831-5

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Effect of E5324, a Novel Inhibitor of Acyl-CoA:Cholesterol Acyltransferase, on Cholesteryl Ester Synthesis and Accumulation in Macrophages

Autor: Hiroko Kobayashi, Teiji Kimura, Isao Saito, Motoji Kogushi, Issei Ohtsuka, Toshie Yamada, Hiroshi Tanaka

Publikováno v: Japanese Journal of Pharmacology. 68:191-199

The in vitro potencies of a novel inhibitor of acyl-CoA :cholesterol acyltransferase (ACAT), E5324 (n-butyl-N'-[2-[3-(5-ethyl-4-phenyl-1H-imidazol-1-yl)propoxy] -6-methylphenyl]urea), were studied. E5324 was found to be a potent ACAT inhibitor in mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::821ff8cbd66f75e21cbb45442b5ca93a
https://doi.org/10.1254/jjp.68.191

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Binding of Biotinylated Thrombin Receptor Peptide to Cloned Human Thrombin Receptor Overexpressed in Baby Hamster Kidney Cells

Autor: Motoji Kogushi, Masahiro Takada, Hiroko Kobayashi, Hiroshi Tanaka, Toshie Yamada, Osamu Ito, Shinji Yoshitake, Isao Saito

Publikováno v: Journal of Receptors and Signal Transduction. 15:103-115

Baby hamster kidney (BHK) cells transfected with an expression vector for the human thrombin receptor, and then treated with basic fibroblast growth factor, were found to express specific and saturable binding sites for biotinylated thrombin receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b078e3678872a33265315403ef15edf0
https://doi.org/10.3109/10799899509045211

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Effect of the acyl-CoA:cholesterol acyltransferase inhibitor, E5324, on experimental atherosclerosis in rabbits

Autor: Kenji Hayashi, Teiji Kimura, Hiroko Kobayashi, Takao Saeki, Hiroshi Tanaka, Toshie Yamada, Tohru Fujimori, Issei Ohtsuka, Motoji Kogushi, Hironobu Hiyoshi, Isao Saito

Publikováno v: Atherosclerosis. 107:187-201

E5324, n-butyl-N′-[2-[3-(5-ethyl-4-phenyl-lH-imidazol-1-yl)propoxy]-6-methylphenyl]urea, a novel and orally absorbable acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, was evaluated for its antiatherosclerotic and antihyperlipidemic effects i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9881561ea685fef4ef2675c3d570b5
https://doi.org/10.1016/0021-9150(94)90020-5

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Inhibitory Effects of a Novel Antiplatelet Agent, E5510, on Collagen-Induced Platelet-Derived Growth Factor Release and Aggregation of Human Platelets In Vitro

Autor: Tohru Fujimori, Isao Yamatsu, Hiroko Kobayashi, Takao Saeki, Kenichi Nomoto, Motoji Kogushi

Publikováno v: Japanese Journal of Pharmacology. 61:7-12

E5510, 4-cyano-5,5-bis(4-methoxyphenyl)-4-pentenoic acid, is a new anti-platelet-aggregation agent under development. We examined the inhibitory efficacy of E5510 on PDGF-release from washed human platelets. E5510 concentration-dependently inhibited

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaecf35cf2064324927f44ec79cc32cc
https://doi.org/10.1254/jjp.61.7

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The novel and orally active thrombin receptor antagonist E5555 (Atopaxar) inhibits arterial thrombosis without affecting bleeding time in guinea pigs

Autor: Shuichi Suzuki, Akiharu Kajiwara, Motoji Kogushi, Hironobu Hiyoshi, Kimiyo Murakami, Ieharu Hishinuma, Tsutomu Kawata, Tetsuya Kawahara, Shinki Kawaguchi, Hiroko Kuramochi, Toshiyuki Matsuoka

Publikováno v: European journal of pharmacology. 657(1-3)

Thrombin is a powerful agonist for platelets, the action of which is mediated by the thrombin receptor protease-activated receptor-1 (PAR-1). Recently, we discovered that E5555 (1-(3-tert-butyl-4-methoxy-5-morpholinophenyl)-2-(5,6-diethoxy-7-fluoro-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e92e03864f4080b1ee5ba523284dd92f
https://pubmed.ncbi.nlm.nih.gov/21300059

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The in-vitro effects of E5555, a protease-activated receptor (PAR)-1 antagonist, on platelet biomarkers in healthy volunteers and patients with coronary artery disease

Autor: Daniela Dastros-Pitei, Motoji Kogushi, Victor L. Serebruany, Marcus Flather, Deepak L. Bhatt

Publikováno v: Thrombosis and haemostasis. 102(1)

SummaryE5555 is a potent protease-activated receptor (PAR-1) antagonist targeting the G-coupled receptor and modulating thrombinplatelet-endothelial interactions. The drug is currently being tested in phase II trials in patients with coronary artery

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f258ca242975fc12338bd64a91e2dc
https://pubmed.ncbi.nlm.nih.gov/19572075

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Structure-activity relationship of N-[2-(dimethylamino)-6-[3-(5-methyl-4-phenyl-1H-imidazol-1-yl)propoxy] phenyl]-N'-pentylurea and analogues. Novel potent inhibitors of acyl-CoA:cholesterol O-acyltransferase with antiatherosclerotic activity

Autor: Ohtsuka I, Takao Saeki, Teiji Kimura, Hayashi K, I. Saitou, Tohru Fujimori, Yamada T, Yasutaka Takase, Motoji Kogushi, Hiroshi Tanaka

Publikováno v: Journal of medicinal chemistry. 36(11)

We have discovered N-butyl-N'-[2-(dimethylamino)-6-[3-(4-phenyl-1H- imidazol-1-yl)propoxy]phenyl]urea (4), a novel, potent, and systemically bioavailable inhibitor of ACAT (acylCoA:cholesterol O-acyltransferase). The structure-activity relationships

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77424e182b7cbff484b18fda2c67a142
https://pubmed.ncbi.nlm.nih.gov/8496930

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