Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Motoi Ueno"'
Publikováno v:
The Journal of antibiotics. 73(9)
Microbial transformation is known to be one of promising options to add functional groups such as a hydroxyl moiety to active base compounds to generate their derivatives. Sordaricin, a diterpene aglycone of the natural product sordarin, is an antifu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8aab49a1536779384862b9f5d7bc51a
https://pubmed.ncbi.nlm.nih.gov/32358585
https://pubmed.ncbi.nlm.nih.gov/32358585
Autor:
Ryuichi Kanasaki, Eisaku Tsujii, Motohiro Hino, Akihiko Fujie, Motoi Ueno, Takashi Fujii, Koji Takakura, Chihoko Ueno, Bunji Sato, Hidenori Nakajima, Akemi Kato, Yukiko Yamagishi
Publikováno v:
The Journal of Antibiotics. 62:95-98
In the previous study, we discovered a polyether antibiotic CP-44161, which was reported earlier as an anticoccidal agent, as an anti-varicella zoster virus compound. In this study, we demonstrated that CP-44161 had a very strong and broad anti-herpe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::484b30e7b3a5fbbdc1fc70a98b053cac
https://doi.org/10.1038/ja.2008.18
https://doi.org/10.1038/ja.2008.18
Publikováno v:
Journal of Bioscience and Bioengineering. 100:567-572
Cytochrome P450 enzymes are a major class of biocatalysts related to the oxidative metabolism of many drugs, assisted by electron transfer partners. The functional expression of the P450 gene in a heterologous host will lead to efficient biotransform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48438bfb0957851eb6bc49df900148cf
https://doi.org/10.1263/jbb.100.567
https://doi.org/10.1263/jbb.100.567
Autor:
Hidetaka Hatori, Motoi Ueno, Shigeru Johki, Hirotsugu Ueda, Satoko Furukawa, Fumie Abe, Michiko Ushioda, Kiyotaka Fujine
Publikováno v:
The Journal of Antibiotics. 57:590-596
The antibiotic thiazole compound siomycin, which we have found from the culture broth of Actinomycetes (strain No.806097) in search of antibody production inhibitor, showed the in vitro immunosuppressive property against B-cells stimulated with T-cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::370b54dad7e920af231e6e4b3ea9399c
https://doi.org/10.7164/antibiotics.57.590
https://doi.org/10.7164/antibiotics.57.590
Autor:
Midori Yamashita, Motoi Ueno, Shigehiro Takase, Akihiko Fujie, Michihiko Kobayashi, Motohiro Hino
Publikováno v:
Journal of bioscience and bioengineering. 117(1)
Bacterial cytochrome P450 enzymes catalyze the oxidative biotransformation of various types of compounds. Although the functional expression of Actinomycetes P450 in a closely related heterologous host can serve as a useful biocatalyst in whole-cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8709b78bdcf414433e92ebd1f495e50b
https://pubmed.ncbi.nlm.nih.gov/23886573
https://pubmed.ncbi.nlm.nih.gov/23886573
Autor:
Nobuharu Shigematsu, Motohiro Hino, Akihiko Fujie, Michizane Hashimoto, Satoshi Sasamura, Motoi Ueno, Midori Yamashita
Publikováno v:
The Journal of antibiotics. 63(11)
Biotransformation technology involving enzymatic modification of original substrates by organisms such as microbes is a valuable tool in improving pharmacokinetics or physicochemical properties of the base compounds. The fungal metabolite AS1387392 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78cbc6c94fcb8fd9d3fa47d545954128
https://pubmed.ncbi.nlm.nih.gov/20924385
https://pubmed.ncbi.nlm.nih.gov/20924385