Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Motoi Kanagawa"'
Autor:
Masumi Matsunuma, Ryuji Kan, Yuji Yamada, Keisuke Hamada, Motoi Kanagawa, Motoyoshi Nomizu, Yamato Kikkawa
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Laminins are a family of heterotrimers composed of α-, β-, and γ-chains in the basement membrane. Five α chains contain laminin globular (LG) domain consisting of five tandem modules (LG1-5 modules) at their C-terminus. Each LG45 modules
Externí odkaz:
https://doaj.org/article/04d84075fc1547feb14cf61249131e25
Autor:
Hideki Tokuoka, Rieko Imae, Hitomi Nakashima, Hiroshi Manya, Chiaki Masuda, Shunsuke Hoshino, Kazuhiro Kobayashi, Dirk J. Lefeber, Riki Matsumoto, Takashi Okada, Tamao Endo, Motoi Kanagawa, Tatsushi Toda
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Ribitol-phospate modification is essential for the function of α-dystroglycan, and mutations in ISPD, an enzyme that synthesizes the the ribitol-phosphate donor CDP-ribitol, cause muscular dystrophy. Here, the authors show that recovery of CDP-ribit
Externí odkaz:
https://doaj.org/article/8eec98bd453046afa082b52bdd681c80
Autor:
Yamato Kikkawa, Masumi Matsunuma, Ryuji Kan, Yuji Yamada, Keisuke Hamada, Motoyoshi Nomizu, Yoichi Negishi, Shushi Nagamori, Tatsushi Toda, Minoru Tanaka, Motoi Kanagawa
Publikováno v:
Matrix Biology Plus, Vol 15, Iss , Pp 100118- (2022)
The linkage between the basement membrane (BM) and cytoskeleton is crucial for muscle fiber stability and signal transduction. Mutations in the linkage molecules can cause various types of muscular dystrophies. The different severities and times of o
Externí odkaz:
https://doaj.org/article/cbb823407e4f4e6eb0a3718198728550
Autor:
Naoyuki Kuwabara, Rieko Imae, Hiroshi Manya, Tomohiro Tanaka, Mamoru Mizuno, Hiroki Tsumoto, Motoi Kanagawa, Kazuhiro Kobayashi, Tatsushi Toda, Toshiya Senda, Tamao Endo, Ryuichi Kato
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Fukutin-related protein (FKRP) catalyses the addition of ribitol-phosphate (RboP) to the O-mannosyl glycan of α-dystroglycan and mutations in FKRP cause dystroglycanopathy. Here the authors provide insights into its oligomerization and recognition o
Externí odkaz:
https://doaj.org/article/a2adec609bc8456584e53ec9bdfe4352
Autor:
Yoshihiro Ujihara, Motoi Kanagawa, Satoshi Mohri, Satomi Takatsu, Kazuhiro Kobayashi, Tatsushi Toda, Keiji Naruse, Yuki Katanosaka
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Mutations in Ftkn cause Fukuyama muscular dystrophy, and heart failure is the main cause of death in thes patients. Here the authors show that acute elimination of Fktn in adult mice causes early mortality, and this is associated with myocyte dysfunc
Externí odkaz:
https://doaj.org/article/820773bb827b414a804a856b83957e6d
Autor:
Shigefumi Morioka, Hirofumi Sakaguchi, Hiroaki Mohri, Mariko Taniguchi-Ikeda, Motoi Kanagawa, Toshiaki Suzuki, Yuko Miyagoe-Suzuki, Tatsushi Toda, Naoaki Saito, Takehiko Ueyama
Publikováno v:
PLoS Genetics, Vol 16, Iss 5, p e1008826 (2020)
Hearing loss (HL) is one of the most common sensory impairments and etiologically and genetically heterogeneous disorders in humans. Muscular dystrophies (MDs) are neuromuscular disorders characterized by progressive degeneration of skeletal muscle a
Externí odkaz:
https://doaj.org/article/e459f0bf0deb4f4bba4537cab949d556
Publikováno v:
Experimental Results, Vol 1 (2020)
The anabolic effects of androgen on skeletal muscles are thought to be mediated by androgen receptor (AR). Although multiple studies concerning the effects of AR in males have been performed, the molecular mechanisms of AR in skeletal muscles remain
Externí odkaz:
https://doaj.org/article/dafd81a9caa347a6945ab93f41d0cfe1
Autor:
Masaki Tsuchiya, Yuji Hara, Masaki Okuda, Karin Itoh, Ryotaro Nishioka, Akifumi Shiomi, Kohjiro Nagao, Masayuki Mori, Yasuo Mori, Junichi Ikenouchi, Ryo Suzuki, Motomu Tanaka, Tomohiko Ohwada, Junken Aoki, Motoi Kanagawa, Tatsushi Toda, Yosuke Nagata, Ryoichi Matsuda, Yasunori Takayama, Makoto Tominaga, Masato Umeda
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Myotube formation by fusion of myoblasts is essential for skeletal muscle formation, but which molecules regulate this process remains elusive. Here authors identify the mechanosensitive PIEZO1 channel as a key element, whose activity is regulated by
Externí odkaz:
https://doaj.org/article/a4b94536489a4c5abfb6db09652f9498
Autor:
Motoi Kanagawa, Kazuhiro Kobayashi, Michiko Tajiri, Hiroshi Manya, Atsushi Kuga, Yoshiki Yamaguchi, Keiko Akasaka-Manya, Jun-ichi Furukawa, Mamoru Mizuno, Hiroko Kawakami, Yasuro Shinohara, Yoshinao Wada, Tamao Endo, Tatsushi Toda
Publikováno v:
Cell Reports, Vol 14, Iss 9, Pp 2209-2223 (2016)
Glycosylation is an essential post-translational modification that underlies many biological processes and diseases. α-dystroglycan (α-DG) is a receptor for matrix and synaptic proteins that causes muscular dystrophy and lissencephaly upon its abno
Externí odkaz:
https://doaj.org/article/be3bb2e74f784761b334a8e2d70b74af
Autor:
Cesare Orlandi, Yoshihiro Omori, Yuchen Wang, Yan Cao, Akiko Ueno, Michel J. Roux, Giuseppe Condomitti, Joris de Wit, Motoi Kanagawa, Takahisa Furukawa, Kirill A. Martemyanov
Publikováno v:
Cell Reports, Vol 25, Iss 1, Pp 130-145.e5 (2018)
Summary: Establishing synaptic contacts between neurons is paramount for nervous system function. This process involves transsynaptic interactions between a host of cell adhesion molecules that act in cooperation with the proteins of the extracellula
Externí odkaz:
https://doaj.org/article/172dc03900564a0eb292748dff84e54d