Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Motohito, Goto"'
Autor:
Ryoji Ito, Yusuke Ohno, Yunmei Mu, Yuyo Ka, Shuko Ito, Maiko Emi-Sugie, Misa Mochizuki, Kenji Kawai, Motohito Goto, Tomoyuki Ogura, Riichi Takahashi, Akira Niwa, Tatsutoshi Nakahata, Mamoru Ito
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-7 (2024)
Abstract Human hematopoietic stem cell (HSC)-transferred humanized mice are valuable models for exploring human hematology and immunology. However, sufficient recapitulation of human hematopoiesis in mice requires large quantities of enriched human C
Externí odkaz:
https://doaj.org/article/5fb3c7fe2ac54a79a530db9b5302a07c
Autor:
Shotaro Uehara, Yuichi Iida, Miyuki Ida-Tanaka, Motohito Goto, Kenji Kawai, Masafumi Yamamoto, Yuichiro Higuchi, Satoshi Ito, Riichi Takahashi, Hidetaka Kamimura, Mamoru Ito, Hiroshi Yamazaki, Mitsuo Oshimura, Yasuhiro Kazuki, Hiroshi Suemizu
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Chimeric TK-NOG mice with a humanized liver (normal Hu-liver) are a unique animal model for predicting drug metabolism in humans. However, residual mouse hepatocytes occasionally prevent the precise evaluation of human drug metabolism. Herei
Externí odkaz:
https://doaj.org/article/1d62c1e9eb1d4e0588116996e7c1f13d
Autor:
Ikumi Katano, Asami Hanazawa, Iyo Otsuka, Takuya Yamaguchi, Misa Mochizuki, Kenji Kawai, Ryoji Ito, Motohito Goto, Takahiro Kagawa, Takeshi Takahashi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer in the clinic. Further discovery of novel drugs or therapeutic protocols that enhance efficacy requires reliable animal models that recapitulate human immune res
Externí odkaz:
https://doaj.org/article/b20ff092b5244208bc65b09380250c63
Autor:
Tomoo Eto, Hiroki Ueda, Ryoji Ito, Tsukasa Takahashi, Toshiaki Watanabe, Motohito Goto, Yusuke Sotomaru, Nobuaki Tanaka, Riichi Takahashi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Genetically modified mice are commonly used in biologic, medical, and drug discovery research, but conventional microinjection methods used for genetic modification require extensive training and practical experience. Here we present a fully
Externí odkaz:
https://doaj.org/article/6be20c5eef20463a9492fcfe4c2710ab
Autor:
Yoichiro Abe, Natsumi Ikegawa, Keitaro Yoshida, Kyosuke Muramatsu, Satoko Hattori, Kenji Kawai, Minetaka Murakami, Takumi Tanaka, Wakami Goda, Motohito Goto, Taichi Yamamoto, Tadafumi Hashimoto, Kaoru Yamada, Terumasa Shibata, Hidemi Misawa, Masaru Mimura, Kenji F. Tanaka, Tsuyoshi Miyakawa, Takeshi Iwatsubo, Jun-ichi Hata, Takako Niikura, Masato Yasui
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-15 (2020)
Abstract Aquaporin-4 (AQP4) has been suggested to be involved in the pathogenesis of neurodegenerative diseases including Alzheimer’s disease (AD), which may be due to the modulation of neuroinflammation or the impairment of interstitial fluid bulk
Externí odkaz:
https://doaj.org/article/1c8558c64520446089d7b86f40ae3269
Autor:
Takuya Yamaguchi, Ikumi Katano, Iyo Otsuka, Ryoji Ito, Misa Mochizuki, Motohito Goto, Takeshi Takahashi
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Despite recent advances in immunodeficient mouse models bearing human red blood cells (hRBCs), the elimination of circulating hRBCs by residual innate immune systems remains a significant challenge. In this study, we evaluated the role of mouse compl
Externí odkaz:
https://doaj.org/article/21811b9530d34276b0c169803db5834e
Autor:
Katsuyuki Nagata, Yuusuke Kakizaki, Keisuke Yanagida, Tetsuya Arai, Kenta Nakano, Fumie Hamano, Motohito Goto, Tadashi Okamura, Takao Shimizu, Hideo Shindou
Publikováno v:
Biochemical and Biophysical Research Communications. 663:179-185
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df1fdeba9ec8461e1d2d57e4eafa06c9
https://doi.org/10.1016/j.bbrc.2023.04.043
https://doi.org/10.1016/j.bbrc.2023.04.043
Autor:
Satoshi Iraha, Hung-Ya Tu, Suguru Yamasaki, Takahiro Kagawa, Motohito Goto, Riichi Takahashi, Takehito Watanabe, Sunao Sugita, Shigenobu Yonemura, Genshiro A. Sunagawa, Take Matsuyama, Momo Fujii, Atsushi Kuwahara, Akiyoshi Kishino, Naoshi Koide, Mototsugu Eiraku, Hidenobu Tanihara, Masayo Takahashi, Michiko Mandai
Publikováno v:
Stem Cell Reports, Vol 10, Iss 3, Pp 1059-1074 (2018)
Summary: Increasing demand for clinical retinal degeneration therapies featuring human ESC/iPSC-derived retinal tissue and cells warrants proof-of-concept studies. Here, we established two mouse models of end-stage retinal degeneration with immunodef
Externí odkaz:
https://doaj.org/article/fa518bf2e7cc40a39d80e76bea362d35
Publikováno v:
Gene Therapy. 30:288-296
A hematopoietic stem cell (HSC) gene therapy (GT) using lentiviral vectors has attracted interest as a promising treatment approach for neuropathic lysosomal storage diseases. To proceed with the clinical development of HSC-GT, evaluation of the ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::324e1e81ff74d5e3d8b1aa04d40203db
https://doi.org/10.1038/s41434-022-00357-y
https://doi.org/10.1038/s41434-022-00357-y
Autor:
Asami Hanazawa, Ryoji Ito, Ikumi Katano, Kenji Kawai, Motohito Goto, Hiroshi Suemizu, Yutaka Kawakami, Mamoru Ito, Takeshi Takahashi
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The tumor microenvironment contains unique immune cells, termed myeloid-derived suppressor cells (MDSCs), and tumor-associated macrophages (TAMs) that suppress host anti-tumor immunity and promote tumor angiogenesis and metastasis. Although these cel
Externí odkaz:
https://doaj.org/article/7d3f4226ec3e4c38888967177ce80167