Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Motohisa Kato"'
Autor:
Feiyong Jia, Jalal Izadi Mobarakeh, Hongmei Dai, Motohisa Kato, Ajing Xu, Tomohiro Okuda, Eiko Sakurai, Nobuyuki Okamura, Kazuhiro Takahashi, Kazuhiko Yanai
Publikováno v:
Journal of Pharmacological Sciences, Vol 107, Iss 2, Pp 167-174 (2008)
The aim of this study was to investigate the effects of histamine H1 and H3 antagonists on learning and mnemonic dysfunction in mice. Two H1 antagonists, pyrilamine and clozapine, and the prototypic H3 antagonist thioperamide were used to study the r
Externí odkaz:
https://doaj.org/article/80208e6485c441a1a5ad3cc00e4f933f
Autor:
Yoshihito Funaki, Motohisa Kato, Ren Iwata, Eiko Sakurai, Eiichi Sakurai, Manabu Tashiro, Tatsuo Ido, Kazuhiko Yanai
Publikováno v:
Journal of Pharmacological Sciences, Vol 91, Iss 2, Pp 105-112 (2003)
Donepezil, an acetylcholinesterase (AChE) inhibitor, has not been evaluated for its binding characteristics using a radioactive tracer, although its inhibitory action on AChE has been studied. The aim of this research is to examine whether AChE can b
Externí odkaz:
https://doaj.org/article/791fc6de18d64f71a3b49dcdcaa48b72
Autor:
Natsuko Fujita, N. Isozaki, Takahiro Watanabe, Tsuneari Ishimaru, N. Okabe, Motohisa Kato, Yoko Saito-Kokubu, Tomohiro Nishio, Chika Ishizaka, Akihiro Matsubara, H. Torazawa, Akimitsu Nishizawa, M. Miyake
Publikováno v:
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms. 456:271-275
JAEA-AMS-TONO has been in operation at the Tono Geoscience Center, Japan Atomic Energy Agency since 1998 and 20 years have passed from the beginning of its utilization. The AMS has been used to measure 14C, 10Be and 26Al. The main use is measurement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1d3630266cb202194acbadb57134cb3
https://doi.org/10.1016/j.nimb.2019.03.015
https://doi.org/10.1016/j.nimb.2019.03.015
Autor:
Hiroyuki Arai, Manabu Tashiro, Shozo Furumoto, Yukitsuka Kudo, Ren Iwata, Motohisa Kato, Yoshihito Funaki, Masaaki Waragai, Kazuhiko Yanai, Nobuyuki Okamura, Katsutoshi Furukawa
Publikováno v:
Journal of the Neurological Sciences. 285:100-108
Two techniques employed for the early diagnosis of dementia are the imaging of amyloid-beta protein using positron emission tomography (PET) and voxel-based morphometry analysis of MRI (VBM-MRI). The purpose of this study was to evaluate the clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c065f63ae72645181b521b079600da5
https://doi.org/10.1016/j.jns.2009.06.005
https://doi.org/10.1016/j.jns.2009.06.005
Autor:
Kazuhiko Yanai, Masayasu Miyake, Motohisa Kato, Ren Iwata, Yoichi Ishikawa, Yoshihito Funaki, Shoichi Watanuki, Manabu Tashiro
Publikováno v:
Human Psychopharmacology: Clinical and Experimental. 24:540-548
Aims The strength of sedation due to antihistamines can be evaluated using positron emission tomography (PET). The purpose of the present study is to measure histamine H1 receptor (H1R) occupancy following oral administration of cetirizine (10 and 20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca1816279f8adaff3c442daeff970194
https://doi.org/10.1002/hup.1051
https://doi.org/10.1002/hup.1051
Autor:
Yoshihito Funaki, Akiko Hayashi, Shoichi Watanuki, Hiroshi Yamasaki, Manabu Tashiro, Motohisa Kato, Kotaro Hiraoka, Kazuhiko Yanai, Nobuyuki Okamura, Etsuro Mori, Toshikatsu Fujii, Hiroshi Watabe, Yoshiyuki Hosokai
Publikováno v:
NeuroImage. 46:616-623
The aim of this study was to establish kinetic analysis of [5-(11)C-methoxy]donepezil ([(11)C]donepezil), which was developed for the in-vivo visualization of donepezil binding to acetylcholinesterase (AChE) using positron emission tomography (PET).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::365136ea9f3b4c547662f34a70e658a0
https://doi.org/10.1016/j.neuroimage.2009.03.006
https://doi.org/10.1016/j.neuroimage.2009.03.006
Autor:
Motohisa Kato, Kazuhiko Yanai, Nobuyuki Okamura, Masahiro Maruyama, Kenichi Meguro, Ren Iwata, Yoichi Ishikawa, Hiroyasu Ishikawa, Yoshihito Funaki, Manabu Tashiro
Publikováno v:
British Journal of Clinical Pharmacology. 65:472-479
What is already known about this subject • Deficit in central cholinergic neurotransmission is a consistent change associated with Alzheimer's disease (AD). • Donepezil hydrochloride exhibits selective inhibition of acetylcholinesterase (AChE) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699b0017d02cd0b5c14a026147d41307
https://doi.org/10.1111/j.1365-2125.2007.03063.x
https://doi.org/10.1111/j.1365-2125.2007.03063.x
Publikováno v:
Polymer Journal. 40:339-342
We investigated the structural development of bubbles during the foaming of polycarbonate under carbon dioxide (CO2) by using a field emission scanning electron microscope (FE-SEM). Numerous CO2 nanopores having a size of around 50 nm were obtained b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb55aeb8aecd048403fb11b63062ebe7
https://doi.org/10.1295/polymj.pj2007138
https://doi.org/10.1295/polymj.pj2007138
Autor:
Motohisa Kato, Hiroyuki Arai, Shozo Furumoto, Yoichi Ishikawa, Tohru Sawada, Yukitsuka Kudo, Yoshihito Funaki, Takayuki Yamamoto, Satoshi Ito, Hiroyasu Akatsu, Takahiro Suemoto, Kazuhiko Yanai, Nobuyuki Okamura
Publikováno v:
Geriatrics & Gerontology International. 7:393-400
Background: In vivo detection of amyloid deposits in the brain is potentially useful for early diagnosis of Alzheimer's disease (AD) and tracking the efficacy of anti-amyloid therapy. Methods: To develop an amyloid-binding agent for positron emission
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b66b5d1f0da1cb33660aa5f2d2d2ba91
https://doi.org/10.1111/j.1447-0594.2007.00430.x
https://doi.org/10.1111/j.1447-0594.2007.00430.x
Autor:
Yuhong Jing, Eiko Sakurai, Kazuhiko Yanai, Nobuyuki Okamura, Atsuo Kuramasu, Motohisa Kato, Kenya Kaneko, Satoshi Fujii, Ajing Xu, Hiroshi Kato, Hongmei Dai
Publikováno v:
Neuroscience Research. 57:306-313
Previous pharmacological experiments provide conflicting findings that describe both facilitatory and inhibitory effects of neuronal histamine on learning and memory. Here, we examined learning and memory and synaptic plasticity in mice with a null m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5dc6bed52ca7731d7417a01bfffaac7
https://doi.org/10.1016/j.neures.2006.10.020
https://doi.org/10.1016/j.neures.2006.10.020