Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Motohiro, Shiotani"'
Autor:
Kazuhiro Kuga1 kazuhiro.kuga@takeda.com, Motohiro Shiotani2, Kentaro Hori3, Hiroshi Mizuno4, Yusaku Matsushita4, Harushige Ozaki1, Kohei Hayashi3, Takatomi Kubo5, Manabu Kano6
Publikováno v:
Journal of Toxicological Sciences. 2024, Vol. 49 Issue 5, p231-240. 10p.
Autor:
Nancy Bower, Takashi Ueno, Carsten T. Beuckmann, Shoji Asakura, Margaret Moline, Motohiro Shiotani, Atsushi Fujiwara, David V. Gauvin
Publikováno v:
Regulatory Toxicology and Pharmacology. 127:105053
Lemborexant is a dual orexin receptor antagonist (DORA) approved in multiple countries including the United States, Japan, Canada and Australia for the treatment of adults with insomnia. As required for marketing approval of new compounds with centra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a3bb9e8406cf9c8f7352275dc228b9
https://doi.org/10.1016/j.yrtph.2021.105053
https://doi.org/10.1016/j.yrtph.2021.105053
Autor:
Tomomi Workman, William C. Griffith, Toby B. Cole, Julie Ju Young Park, Sungwoo Hong, Elaine M. Faustman, Lucio G. Costa, Motohiro Shiotani, Thomas M. Burbacher
Publikováno v:
Neurotoxicology and Teratology. 64:8-19
Domoic acid (DA) is an algal toxin which has been associated with significant neurotoxicity in humans, non-human primates, rodents, and marine mammals. Developmental exposure to DA is believed to result in neurotoxicity that may persist into adulthoo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d435b3297bbd921fa6d4c0dd93f43b53
https://doi.org/10.1016/j.ntt.2017.09.002
https://doi.org/10.1016/j.ntt.2017.09.002
AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis
Autor:
Paul M. O'Neill, Edward W. Tate, W. David Hong, Adam P. Roberts, Marc P. Hübner, Peter J. H. Webborn, Mark J. Taylor, Alexandra Ehrens, Stefan J. Frohberger, Dominique Struever, John Archer, Farid Benayoud, Joseph D. Turner, Rachel H. Clare, Achim Hoerauf, Stefan Kavanagh, Fabian Gusovsky, Andrew Steven, Neil G. Berry, Kelly L. Johnston, Ghaith Aljayyoussi, Andrew Cassidy, Remigiusz A. Serwa, Suet C. Leung, Janet Hemingway, Alasdair T. M. Hubbard, Gemma L. Nixon, Amy Siu, Stephen A. Ward, Emma A Murphy, Louise Ford, Li Qie, Motohiro Shiotani, Darren A. N. Cook
Publikováno v:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Onchocerciasis and lymphatic filariasis are two neglected tropical diseases that together affect ∼157 million people and inflict severe disability. Both diseases are caused by parasitic filarial nematodes with elimination efforts constrained by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d971c5d526af7ac9de5fb24d20f2893d
Autor:
W David, Hong, Farid, Benayoud, Gemma L, Nixon, Louise, Ford, Kelly L, Johnston, Rachel H, Clare, Andrew, Cassidy, Darren A N, Cook, Amy, Siu, Motohiro, Shiotani, Peter J H, Webborn, Stefan, Kavanagh, Ghaith, Aljayyoussi, Emma, Murphy, Andrew, Steven, John, Archer, Dominique, Struever, Stefan J, Frohberger, Alexandra, Ehrens, Marc P, Hübner, Achim, Hoerauf, Adam P, Roberts, Alasdair T M, Hubbard, Edward W, Tate, Remigiusz A, Serwa, Suet C, Leung, Li, Qie, Neil G, Berry, Fabian, Gusovsky, Janet, Hemingway, Joseph D, Turner, Mark J, Taylor, Stephen A, Ward, Paul M, O'Neill
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Onchocerciasis (river blindness) and lymphatic filariasis (elephantiasis) are neglected tropical diseases that cause severe disability and affect more than 157 million people globally. Current control efforts are hindered by the lack of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a67afcb9d9f3a9d55bf8c9a97e46c9a1
https://pubmed.ncbi.nlm.nih.gov/30617067
https://pubmed.ncbi.nlm.nih.gov/30617067
Autor:
Yoshikazu Taketa1 y-taketa@hhc.eisai.co.jp, Motohiro Shiotani1, Yoshiharu Tsuru2, Sadaharu Kotani3, Yoshihide Osada3, Tatsuto Fukushima3, Akira Inomata1, Satoru Hosokawa1
Publikováno v:
Journal of Toxicologic Pathology. 2015, Vol. 28 Issue 4, p217-224. 8p.
Autor:
Sadaharu Kotani, Motohiro Shiotani, Akira Inomata, Tatsuto Fukushima, Yoshikazu Taketa, Yoshiharu Tsuru, Satoru Hosokawa, Yoshihide Osada
Publikováno v:
Journal of Toxicologic Pathology
Magnetic resonance imaging (MRI) is a useful noninvasive tool used to detect lesions in clinical and veterinary medicine. The present study evaluated the suitability of a new easy-to-use compact MRI platform (M2 permanent magnet system, Aspect Imagin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::034e398668a3de3f236a675cc821ecb7
http://europepmc.org/articles/PMC4604131
http://europepmc.org/articles/PMC4604131
Methodological validation of an existing telemetry system for QT evaluation in conscious guinea pigs
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 55:27-34
Introduction:Guinea pigs are suitable for in vivo QT assessment of newly discovered drugs at the pre-clinical stage because of the ease with which these animals can be handled, the lower amount of compound required for testing, and the similarity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3352608e7e54efc1c5b673c99a72990f
https://doi.org/10.1016/j.vascn.2006.04.008
https://doi.org/10.1016/j.vascn.2006.04.008
Autor:
Yasufusa Sawada, Junko Abe, Ikuo Horii, Yoshimasa Hamada, Motohiro Shiotani, Keitaro Hashimoto, Takuma Harada
Publikováno v:
The Journal of Toxicological Sciences. 30:239-247
The purpose of this study was to evaluate a telemetry system for examining QT evaluation in the conscious free-moving guinea pig using 10 reference compounds whose effects on human QT interval are well established: 8 positive references (bepridil, te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe9a5663c4ea82b9f6da0aa339312c5
https://doi.org/10.2131/jts.30.239
https://doi.org/10.2131/jts.30.239
Autor:
Kentaro Fujita, S. K. Bandyopadhyay, A. Nuntaprasert, Chieko Kai, M. D. Baron, Thomas Barrett, Ryuichi Miura, Misako Yoneda, Motohiro Shiotani
Publikováno v:
Journal of General Virology. 83:1457-1463
A major molecular determinant of virus host-range is thought to be the viral protein required for cell attachment. We used a recombinant strain of Rinderpest virus (RPV) to examine the role of this protein in determining the ability of RPV to replica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6edfc50e1a62feb17b7a415557aaf8f4
https://doi.org/10.1099/0022-1317-83-6-1457
https://doi.org/10.1099/0022-1317-83-6-1457