Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Motohiko, Kadoki"'
Autor:
Ce Tang, Haiyang Sun, Motohiko Kadoki, Wei Han, Xiaoqi Ye, Yulia Makusheva, Jianping Deng, Bingbing Feng, Ding Qiu, Ying Tan, Xinying Wang, Zehao Guo, Chanyan Huang, Sui Peng, Minhu Chen, Yoshiyuki Adachi, Naohito Ohno, Sergio Trombetta, Yoichiro Iwakura
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
The effect of β-glucans and their receptor Dectin-1 in tumor development remains controversial. Here the authors show that Dectin-1 signaling promotes the development of colorectal cancer (CRC) by inducing prostaglandin E2 production in myeloid-deri
Externí odkaz:
https://doaj.org/article/ac5a7567c27846ed934a829b63683efa
Autor:
Motohiko Kadoki, Daniel B. Graham, Mark J. Daly, Ariel Lefkovith, Helen Lin, Toru Nakata, Martin K. Selig, Elizabeth A. Creasey, Junmei Yao, Ramnik J. Xavier
Publikováno v:
Proceedings of the National Academy of Sciences. 117:28930-28938
Common genetic variants interact with environmental factors to impact risk of heritable diseases. A notable example of this is a single-nucleotide variant in the Solute Carrier Family 39 Member 8 (SLC39A8) gene encoding the missense variant A391T, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63ab7b42536d24969bc6ff919e629c4e
https://doi.org/10.1073/pnas.2014742117
https://doi.org/10.1073/pnas.2014742117
Autor:
Toru, Nakata, Elizabeth A, Creasey, Motohiko, Kadoki, Helen, Lin, Martin K, Selig, Junmei, Yao, Ariel, Lefkovith, Mark J, Daly, Daniel B, Graham, Ramnik J, Xavier
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance SLC39A8 A391T exhibits remarkable pleiotropic effects on multiple conditions, including cardiovascular diseases, Parkinson’s disease, and Crohn’s disease. However, how this single coding variant impacts such a wide range of pathologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::70d264ee6a4da04b282663fb8bc46b82
https://pubmed.ncbi.nlm.nih.gov/33139556
https://pubmed.ncbi.nlm.nih.gov/33139556
Autor:
Tomoyuki Shimazu, Kenji Shimizu, Motohiko Kadoki, Ce Tang, Shigeru Kakuta, Tomonori Kamiya, Sachiko Kubo, Yoichiro Iwakura, Shinobu Saijo, Susumu Nakae, Harumichi Ishigame
Publikováno v:
Nature Immunology. 19:755-765
The cytokines IL-17A and IL-17F have 50% amino-acid identity and bind the same receptor; however, their functional differences have remained obscure. Here we found that Il17f-/- mice resisted chemically induced colitis, but Il17a-/- mice did not, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61758f8aa6175af4a5e3c18e4d3e4e06
https://doi.org/10.1038/s41590-018-0134-y
https://doi.org/10.1038/s41590-018-0134-y
Autor:
Andrew C. Tolonen, Mukund Varma, Isabel J. Latorre, Kara L. Conway, Betsabeh Khoramian Tusi, Aylwin Ng, Ariel Lefkovith, Bernard Khor, Vishnu Mohanan, Motohiko Kadoki, Daniel B. Graham, Kevin Gao, Ramnik J. Xavier
Publikováno v:
J Immunol
Genome-wide association studies have identified common genetic variants impacting human diseases; however, there are indications that the functional consequences of genetic polymorphisms can be distinct depending on cell type–specific contexts, whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4485da3b7c425a84b12e4db8223adec6
https://pubmed.ncbi.nlm.nih.gov/32522834
https://pubmed.ncbi.nlm.nih.gov/32522834
Autor:
Shigeru Kakuta, Masahira Hattori, Yang Liu, Takanori Kanai, Kozue Takeshita, Kenshiro Oshima, Naohito Ohno, Shinobu Saijo, Motohiko Kadoki, Tomonori Kamiya, Yoichiro Iwakura, Ce Tang
Publikováno v:
Cell Host & Microbe. 18(2):183-197
Dectin-1, the receptor for β-glucans, protects the host against fungal infection; however, its role in intestinal immunity is incompletely understood. We found that Dectin-1-deficient (Clec7a(-/-)) mice were refractory to both dextran sodium sulfate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c7591298970c8715ee059cdcd6cdede
Autor:
Surya Pandey, Cornelius C. Thaiss, Ulrich H. von Andrian, Ashwini Patil, Nicolas Chevrier, Motohiko Kadoki, Kenta Nakai, Amy J. Wagers, David Alvarez, Deeksha Deep, Magali Soumillon, Donald J. Brooks, Tarjei S. Mikkelsen
Publikováno v:
Cell. 171(2)
A fundamental challenge in immunology is to decipher the principles governing immune responses at the whole-organism scale. Here, using a comparative infection model, we observe immune signal propagation within and between organs to obtain a dynamic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c453b76c48353f5493d21fcbea3418e
https://pubmed.ncbi.nlm.nih.gov/29229265
https://pubmed.ncbi.nlm.nih.gov/29229265
Autor:
Varma, Mukund1, Motohiko Kadoki1,2,3, Lefkovith, Ariel1, Conway, Kara L.2, Gao, Kevin2, Mohanan, Vishnu1,2,3, Tusi, Betsabeh Khoramian1,2,3, Graham, Daniel B.1,3,4, Latorre, Isabel J.1,2,3, Tolonen, Andrew C.1, Khor, Bernard2, Ng, Aylwin1,4 aylwin.ng@gmail.com, Xavier, Ramnik J.1,2,3,4 xavier@molbio.mgh.harvard.edu
Publikováno v:
Journal of Immunology. 7/15/2020, Vol. 205 Issue 2, p414-424. 11p.
Autor:
Ce Tang, Naohito Ohno, Yoichiro Iwakura, Shinobu Saijo, Motohiko Kadoki, Masahira Hattori, Kenshiro Oshima, Tomonori Kamiya, Yoshiyuki Adachi
Publikováno v:
Mucosal immunology. 11(3)
Dectin-1 (gene symbol: Clec7a) is a receptor for β-glucans that play an important role for the host defense against fungi. Recently, we showed that Clec7a-/- mice are resistant against dextran sodium sulfate (DSS)-induced colitis because of regulato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b0e29238ff4998f04687e2b294d5787
https://pubmed.ncbi.nlm.nih.gov/29068000
https://pubmed.ncbi.nlm.nih.gov/29068000
Autor:
Aya Nambu, Yutaka Komiyama, Katsuko Sudo, Susumu Nakae, Hayato Kotaki, Harumichi Ishigame, Yuko Tanahashi, Takeshi Nagai, Shigeru Kakuta, Yoichiro Iwakura, Motohiko Kadoki, Noriyuki Fujikado, Aoi Akitsu, Chihiro Sasakawa
Publikováno v:
Immunity. 30:108-119
Interleukin-17A (IL-17A) is a cytokine produced by T helper 17 (Th17) cells and plays important roles in the development of inflammatory diseases. Although IL-17F is highly homologous to IL-17A and binds the same receptor, the functional roles of thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::441bce42a4aa13ba42eda4c0ba8f7391
https://doi.org/10.1016/j.immuni.2008.11.009
https://doi.org/10.1016/j.immuni.2008.11.009