Zobrazeno 1 - 10
of 342
pro vyhledávání: '"Motohatsu Fujiwara"'
Publikováno v:
Journal of Neurochemistry. 47:1294-1301
Using ligand binding techniques, we studied alpha-adrenergic receptors in brains obtained at autopsy from seven histologically normal controls and seven patients with histopathologically verified Alzheimer-type dementia (ATD). Binding of the alpha-ad
Publikováno v:
Journal of Neurochemistry. 47:63-69
The effects of hypoxia (10% O2, 90% N2) on the content, biosynthesis, and turnover of noradrenaline (NA) and 3,4-dihydroxyphenylethylamine (dopamine, DA) in the rat brain were examined. Up to 24 h following exposure to hypoxia, NA content in the whol
Publikováno v:
Japanese Journal of Pharmacology. 68:183-189
The present investigation was undertaken to characterize the relaxing responsiveness in aortic strips from rats with arteriosclerosis, which was produced by excess vitamin D2 (VD) administration followed by treatment with or without a high-cholestero
Autor:
Keisuke Hattori, Yoko Tanabe, Kazumasa Shinozuka, Yu Yamaguchi, Motohatsu Fujiwara, Satomi Kitagawa, Masaru Kunitomo
Publikováno v:
European Journal of Pharmacology: Environmental Toxicology and Pharmacology. 292:115-118
Noradrenaline significantly increased (by a prazosin-sensitive mechanism) the overflow of ATP and its metabolites from the caudal arteries of rats treated with excess vitamin D2 and a high-cholesterol diet (arteriosclerotic rats), although the amount
Publikováno v:
Life Sciences. 55:491-498
Studies were designed to determine the extent of the involvement of endothelium-derived relaxing factor(s) other than nitric oxide (NO) in vascular relaxation in response to acetylcholine (ACh) in the rabbit renal artery. ACh (10(-9)-10(-6) M) induce
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 30:169-175
We tried to develop an experimental model using mice for the primary screening of antiatherosclerotic agents. Male ICR strain mice were given a high-cholesterol diet supplemented with 10% linoleic acid for 14 weeks. Throughout the experimental period
Publikováno v:
Japanese Journal of Pharmacology. 62:257-261
We characterized the pharmacological nature of the tachykinin receptor subtype mediating the contractile response to electrical transmural stimulation (ETS) in the isolated rabbit iris sphincter muscle preparation by using selective NK1-receptor anta
Publikováno v:
Japanese Journal of Pharmacology. 61:291-298
Autoimmune MRL-lpr/lpr (MRL/l) mice, with a systemic lupus erythematosus-like disease, were shown to spontaneously develop hyperlipidemia and yet be susceptible to diet-induced hypercholesterolemia and aortic cholesterol deposition. Control animals o
Autor:
Haruaki Ninomiya, Motohatsu Fujiwara
Publikováno v:
Japanese Journal of Pharmacology. 57:349-354
Autor:
Koichi Ebii, Reiko Fukunaga, Takashi Taniguchi, Motohatsu Fujiwara, Sunao Nakayama, Yuichi Saitoh, Yukio Kimura
Publikováno v:
Japanese Journal of Pharmacology. 56:505-512