Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Motoharu Ono"'
Enhanced snoMEN Vectors Facilitate Establishment of GFP-HIF-1α Protein Replacement Human Cell Lines.
Autor:
Motoharu Ono, Kayo Yamada, Dalila Bensaddek, Vackar Afzal, John Biddlestone, Brian Ortmann, Sharon Mudie, Vincent Boivin, Michelle S Scott, Sonia Rocha, Angus I Lamond
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0154759 (2016)
The snoMEN (snoRNA Modulator of gene ExpressioN) vector technology was developed from a human box C/D snoRNA, HBII-180C, which contains an internal sequence that can be manipulated to make it complementary to RNA targets, allowing knock-down of targe
Externí odkaz:
https://doaj.org/article/3f3efeaac1594ece912c3dd27558baf4
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138668 (2015)
We have previously reported an antisense technology, 'snoMEN vectors', for targeted knock-down of protein coding mRNAs using human snoRNAs manipulated to contain short regions of sequence complementarity with the mRNA target. Here we characterise the
Externí odkaz:
https://doaj.org/article/4021a8ddde934474ab6bc65a4e63f42e
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62305 (2013)
The study of the function of many human proteins is often hampered by technical limitations, such as cytotoxicity and phenotypes that result from overexpression of the protein of interest together with the endogenous version. Here we present the snoM
Externí odkaz:
https://doaj.org/article/016def3fb55b487daee938b2224d9970
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 9, p e1000507 (2009)
MicroRNAs (miRNAs) and small nucleolar RNAs (snoRNAs) are two classes of small non-coding regulatory RNAs, which have been much investigated in recent years. While their respective functions in the cell are distinct, they share interesting genomic si
Externí odkaz:
https://doaj.org/article/f92bc17325f64b24b331257419185282
Autor:
Andrew M. Kidger, Mark K. Saville, Linda K. Rushworth, Jane Davidson, Julia Stellzig, Motoharu Ono, Ludwig A. Kuebelsbeck, Klaus-Peter Janssen, Bernhard Holzmann, Jennifer P. Morton, Owen J. Sansom, Christopher J. Caunt, Stephen M. Keyse
Publikováno v:
Oncogene. 41:2811-2823
The cytoplasmic phosphatase DUSP6 and its nuclear counterpart DUSP5 are negative regulators of RAS/ERK signalling. Here we use deletion of either Dusp5 or Dusp6 to explore the roles of these phosphatases in a murine model of KRASG12D-driven pancreati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7040fc8693ecb4188b536f1fa542ede0
https://doi.org/10.1038/s41388-022-02302-0
https://doi.org/10.1038/s41388-022-02302-0
Autor:
Andrew M, Kidger, Mark K, Saville, Linda K, Rushworth, Jane, Davidson, Julia, Stellzig, Motoharu, Ono, Ludwig A, Kuebelsbeck, Klaus-Peter, Janssen, Bernhard, Holzmann, Jennifer P, Morton, Owen J, Sansom, Christopher J, Caunt, Stephen M, Keyse
Publikováno v:
Oncogene. 41(20)
The cytoplasmic phosphatase DUSP6 and its nuclear counterpart DUSP5 are negative regulators of RAS/ERK signalling. Here we use deletion of either Dusp5 or Dusp6 to explore the roles of these phosphatases in a murine model of KRAS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2809ff027699cd28e48ce0911416b762
https://pubmed.ncbi.nlm.nih.gov/35418690
https://pubmed.ncbi.nlm.nih.gov/35418690
Autor:
Mikio Fujiwara, Ryo Namiki, Masahide Sasaki, Takuya Hirano, Akio Tajima, Ken-ichiro Yoshino, Tobias A. Eriksson, Motoharu Ono, Masahiro Takeoka
We study coexistence of CV-QKD and 7 classical 12.5 Gbit/s on-off keying channels in WDM transmission over the C-band. We demonstrate key generation with a distilled secret key rate between 20 to 50 kbit/s in experiments running continuously over 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42214c569aa705f453d4e598e0b2ca1f
http://arxiv.org/abs/1809.01287
http://arxiv.org/abs/1809.01287
Publikováno v:
Molecular Cell; Vol 49
Molecular Cell
Molecular Cell
Summary The ARF tumor suppressor is a central component of the cellular defense against oncogene activation in mammals. p14ARF activates p53 by binding and inhibiting HDM2, resulting, inter alia, in increased transcription and expression of the cycli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fde8f1904c4d0b87b24170a6ed16706f
Autor:
Takuya Hirano, Toyohiro Tsurumaru, Kenta Kasai, Takuto Matsubara, Tsubasa Ichikawa, Ryutaroh Matsumoto, Yusuke Oguri, Motoharu Ono
Publikováno v:
Quantum Information Science and Technology II.
We report on the development of continuous-variable quantum key distribution (CV-QKD) system that are based on discrete quadrature amplitude modulation (QAM) and homodyne detection of coherent states of light. We use a pulsed light source whose wavel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd4e7ac234041df222d5fd1be733e8e9
https://doi.org/10.1117/12.2241766
https://doi.org/10.1117/12.2241766
Autor:
Kayo Yamada, Akinori Endo, Motoharu Ono, Angus I. Lamond, Michelle S. Scott, Geoffrey J. Barton
Publikováno v:
Nucleic Acids Research
Small nucleolar RNAs (snoRNAs) function mainly as guides for the post-transcriptional modification of ribosomal RNAs (rRNAs). In recent years, several studies have identified a wealth of small fragments (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e75d802ff6330ed8c0c9ce220b79ef
https://doi.org/10.1093/nar/gkr1233
https://doi.org/10.1093/nar/gkr1233