Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Motoharu Iwatsuru"'
Autor:
Toshiro Mizoue, Motoharu Iwatsuru, Toshiya Horibe, Tomoko Takizawa, Kenji Kono, Fuminori Moriyasu, Hironobu Yanagie, Kazuo Maruyama
Publikováno v:
International Journal of Pharmaceutics. 237:129-137
We prepared tumor-specific immunoliposomes by coupling anti-BCG monoclonal antibodies to pH-sensitive fusogenic liposomes modified with succinylated polyglycidol (sucPG), in order to obtain efficient binding to, and endocytotic internalization into,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7838b63cd272ea54c0b9698804e72d7
https://doi.org/10.1016/s0378-5173(02)00044-3
https://doi.org/10.1016/s0378-5173(02)00044-3
Autor:
Kazuo Maruyama, Hiroyuki Tanahashi, Hironobu Yanagie, Masazumi Eriguchi, Motoharu Iwatsuru, Osamu Ishida, Katsunori Sasaki
Publikováno v:
Pharmaceutical Research. 18:1042-1048
Purpose. The purpose of this study was to determine the usefulness of transferrin (TF)-pendant-type polyethyleneglycol (PEG)-liposomes (TF-PEG-liposomes), in which TF was covalently linked to the distal terminal of PEG chains on the external surface
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15acf19d2bc4d21697f6051a8e5e3a71
https://doi.org/10.1023/a:1010960900254
https://doi.org/10.1023/a:1010960900254
Publikováno v:
International Journal of Pharmaceutics. 193:97-106
We investigated the molecular localization and state of amphotericin B (AmB) encapsulated in polyethylene glycol (PEG)-coated liposomes. AmB-encapsulating PEG-liposomes composed of dipalmitoylphosphatidylcholine (DPPC), cholesterol (CH) and distearoy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d17b02ca6c901f8047e748cf295e373c
https://doi.org/10.1016/s0378-5173(99)00323-3
https://doi.org/10.1016/s0378-5173(99)00323-3
Publikováno v:
International Journal of Pharmaceutics. 190:49-56
We have examined the size dependence of extravasation and interstitial localization of polyethyleneglycol-coated liposomes (PEG-liposomes) in the solid tumor tissue by means of electron microscopic observation. Liposomes composed of distearoyl phosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de3754f337e460cb4912ca95ce9403d9
https://doi.org/10.1016/s0378-5173(99)00256-2
https://doi.org/10.1016/s0378-5173(99)00256-2
Publikováno v:
International Journal of Pharmaceutics. 188:193-202
In this study, we characterized the encapsulation of amphipathic nystatin into liposomes with or without cholesterol (CH) and a polyethylene glycol derivative, distearoyl-N-(monomethoxy poly(ethylene glycol)succinyl)phosphatidylethanolamine (DSPE-PEG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9beb3cc85c9f0ee602a21ed88cfb85f9
https://doi.org/10.1016/s0378-5173(99)00222-7
https://doi.org/10.1016/s0378-5173(99)00222-7
Publikováno v:
Drug Delivery System. 13:407-414
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bf313555285203b786a947ca24fbc70
https://doi.org/10.2745/dds.13.407
https://doi.org/10.2745/dds.13.407
Publikováno v:
Pharmaceutical Research. 15:1737-1742
Purpose. A highly efficient method was developed for the encapsulation of amphotericin B (AmB) in liposomes, and the mechanism involved was characterized.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c60ad66467f0862468f782c8e8477f9
https://doi.org/10.1023/a:1011912829747
https://doi.org/10.1023/a:1011912829747
Publikováno v:
FEBS Letters. 413:177-180
We have developed a new type of long-circulating immunoliposome (Fab′–PEG immunoliposomes) which is efficiently extravasated into the targeted solid tumor in vivo. Small unilamellar liposomes (100–130 nm in diameter) were prepared from distearo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54f4d6898bf79e27fb374c499187ccd4
https://doi.org/10.1016/s0014-5793(97)00905-8
https://doi.org/10.1016/s0014-5793(97)00905-8
Autor:
Tomoko Takizawa, Toshiaki Tagawa, Nobuya Takahashi, Motoharu Iwatsuru, Kazuo Maruyama, Kazuhiro Nagaike
Publikováno v:
Advanced Drug Delivery Reviews. 24:235-242
We have developed a new type of PEG-immunoliposome carrying monoclonal antibodies or their fragments (F(ab′)2, Fab′) at the distal ends of the PEG chains (Type C). Distearoylphosphatidylethanolamine derivatives of PEG with car☐yl group (DSPE-PE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7a2320a1655fba5b92e580e98ba0e3c
https://doi.org/10.1016/s0169-409x(96)00463-2
https://doi.org/10.1016/s0169-409x(96)00463-2
Publikováno v:
Chemical and Pharmaceutical Bulletin. 45:1683-1687
Poly(ethylene glycol)-coated liposomes (PEG-liposomes) were prepared from distearoylphosphatidylcholine (DSPC)/cholesterol (Ch) (1:1, molar ratio) with various amounts of distearoyl-N-(monomethoxy poly(ethylene glycol)succinyl)phosphatidylethanolamin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a6cb5e7ad8d14719dd0063d53ae9be8
https://doi.org/10.1248/cpb.45.1683
https://doi.org/10.1248/cpb.45.1683