Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Motoaki Ohtsubo"'
Autor:
Yoshinori Ohno, Kyoko Suzuki-Takedachi, Shin'ichiro Yasunaga, Toshiaki Kurogi, Mimoko Santo, Yoshikazu Masuhiro, Shigemasa Hanazawa, Motoaki Ohtsubo, Kazuhito Naka, Yoshihiro Takihara
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155558 (2016)
Geminin regulates chromatin remodeling and DNA replication licensing which play an important role in regulating cellular proliferation and differentiation. Transcription of the Geminin gene is regulated via an E2F-responsive region, while the protein
Externí odkaz:
https://doaj.org/article/2c0e98ef86964895a4e0309e70097988
Autor:
Yoshinori Ohno, Shin'ichiro Yasunaga, Salima Janmohamed, Motoaki Ohtsubo, Keita Saeki, Toshiaki Kurogi, Keichiro Mihara, Norman N Iscove, Yoshihiro Takihara
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53161 (2013)
Hoxb4, a 3'-located Hox gene, enhances hematopoietic stem cell (HSC) activity, while a subset of 5'-located Hox genes is involved in hematopoiesis and leukemogenesis, and some of them are common translocation partners for Nucleoporin 98 (Nup98) in pa
Externí odkaz:
https://doaj.org/article/634246b9d6a346179ece6d459995ed46
Autor:
Motoaki Ohtsubo, Akiyo Hayashi, Hideo Nishitani, Kohei Nukina, Kaoru Sugasawa, Yasushi Shiomi
Publikováno v:
Genes to Cells. 23:200-213
CRL4Cdt2 ubiquitin ligase plays an important role maintaining genome integrity during the cell cycle. A recent report suggested that Cdk1 negatively regulates CRL4Cdt2 activity through phosphorylation of its receptor, Cdt2, but the involvement of pho
Autor:
Ikue Hata, Satoshi Okada, Go Tajima, Masao Kobayashi, Miyuki Tsumura, Nobuo Sakura, Shin'ichiro Yasunaga, Reiko Kagawa, Yoshihiro Takihara, Motoaki Ohtsubo, Keiichi Hara, Yosuke Shigematsu, Kenichiro Shirao, Yoshinori Ohno
Publikováno v:
Molecular Genetics and Metabolism. 118:9-14
Background Since the first case was detected in 2000, there has been a remarkable increase in Japanese patients diagnosed with medium-chain acyl-CoA dehydrogenase (MCAD) deficiency. Genetic analysis has revealed a spectrum of mutations that is quite
Autor:
Kohei, Nukina, Akiyo, Hayashi, Yasushi, Shiomi, Kaoru, Sugasawa, Motoaki, Ohtsubo, Hideo, Nishitani
Publikováno v:
Genes to cells : devoted to molecularcellular mechanisms. 23(3)
CRL4
Autor:
Toshiaki Kurogi, Kyoko Suzuki-Takedachi, Yoshihiro Takihara, Yoshinori Ohno, Motoaki Ohtsubo, Kenichi Yoshida, Keita Saeki, Manabu Shirai, Shin'ichiro Yasunaga, J. Willem Voncken, Keichiro Mihara
Publikováno v:
Molecular Biology of the Cell
Molecular Biology of the Cell, 25(8), 1374-1383. American Society for Cell Biology
Molecular Biology of the Cell, 25(8), 1374-1383. American Society for Cell Biology
Geminin transcription, regulated by E2Fs, is negatively regulated by Geminin through the inhibition of chromatin remodeling. Geminin transcription is thus regulated by a negative-feedback loop through the chromatin configuration. Homeostatically regu
Autor:
Motoaki Ohtsubo, Naoto Shirasu, Bo Zhang, Kyoko Suzuki-Takedachi, Yoshinori Ohno, Yoshihiro Takihara, Shin'ichiro Yasunaga
Publikováno v:
International journal of hematology. 104(3)
Geminin exerts two distinct molecular roles. Geminin negatively regulates DNA replication licensing through the direct interaction with Cdt1 to prevent re-replication in proliferating cells. Geminin also regulates chromatin remodeling through the dir
Autor:
Satoshi Okada, Mohammed A. Al Shehri, Takuji Murata, Motoaki Ohtsubo, Miyuki Tsumura, Geyhad ElGhazali, Yoshihiro Takihara, Takahiro Yasumi, Ryuta Nishikomori, Masao Kobayashi, Jean-Laurent Casanova, Avinash Abhyankar, Shin'ichiro Yasunaga, Xiao-Fei Kong, Hideto Obata, Saleh Al-Muhsen, Tatsutoshi Nakahata, Toshio Heike, Mofareh AlZahrani, Hidemasa Sakai, Stéphanie Boisson-Dupuis
Publikováno v:
Human Mutation. 33:1377-1387
Patients carrying two loss-of-function (or hypomorphic) alleles of STAT1 are vulnerable to intracellular bacterial and viral diseases. Heterozygosity for loss-of-function dominant-negative mutations in STAT1 is responsible for autosomal dominant (AD)
Autor:
Joyeeta Bhattacharyya, Yoshifumi Takei, Akiro Kimura, Kazuyoshi Yanagihara, Akira Sakai, Motoaki Ohtsubo, Masaharu Hoshi, Shin'ichiro Yasunaga, Yoshihiro Takihara, Keichiro Mihara
Publikováno v:
Cancer Science. 103:34-41
The expression of BMI-1 is correlated with disease progression in cancer patients. We showed that ectopic expression of BMI-1 in B-cell lymphoma cell lines, HT and RL, conferred resistance to etoposide and oxaliplatin, known to enhance sensitivity by
Autor:
Yoshihiro Takihara, Tomoki Kawai, Norioki Ohno, Ryuta Nishikomori, Satoshi Okada, Masao Kobayashi, Motoaki Ohtsubo, Miyuki Tsumura, Yoko Mizoguchi, Shin'ichiro Yasunaga, Takemasa Sakaguchi, Shuhei Karakawa
Publikováno v:
Journal of Clinical Immunology. 31:762-772
X-linked ectodermal dysplasia with immunodeficiency (XL-ED-ID) is caused by hypomorphic mutations in NEMO, which encodes nuclear factor-kappaB (NF-κB) essential modulator. We identified a novel mutation, 769-1 G>C, at the splicing acceptor site of e