Synthesis, biological evaluation and docking studies of silicon incorporated diarylpyrroles as MmpL3 inhibitors: An effective strategy towards development of potent anti-tubercular agents.

Autor: Vasudevan N; CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune, 411008, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Motiwala Z; CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune, 411008, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Ramesh R; CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune, 411008, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Wagh SB; CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune, 411008, India., Shingare RD; CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune, 411008, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Katte R; CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune, 411008, India., Anand A; CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, 110025, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Choudhary S; CSIR-Indian Institute of Integrative Medicine, Post Bag No. 3, Canal Rd, Jammu, 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Kumar A; CSIR-Indian Institute of Integrative Medicine, Post Bag No. 3, Canal Rd, Jammu, 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Gokhale RS; CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, 110025, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India; Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune, 411008, India; Immunometabolism Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, 110067, India., Kulkarni KA; CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune, 411008, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. Electronic address: ka.kulkarni@ncl.res.in., Reddy DS; CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune, 411008, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. Electronic address: ds.reddy@iict.res.in.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2023 Nov 05; Vol. 259, pp. 115633. Date of Electronic Publication: 2023 Jul 16.

Wavelet coherence phases decode the universal switching mechanism of Ras GTPase superfamily

Autor: Durba Sengupta, Motiwala Z, Anand S. Sandholu, Kiran Kulkarni

Ras superfamily GTPases are molecular switches which regulate critical cellular processes. Extensive structural and computational studies on this G protein family have tried to establish a general framework for their switching mechanism. The current

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d90c732dc7a3b9ceec0a2cc39c7d9f5
https://doi.org/10.1101/2020.08.15.252247

Publisher Correction: Structural basis of GABA reuptake inhibition.

Autor: Motiwala Z; Bridge Institute, USC Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA, USA.; Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA., Aduri NG; Bridge Institute, USC Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA, USA.; Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA., Shaye H; Bridge Institute, USC Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA, USA.; Department of Chemistry, University of Southern California, Los Angeles, CA, USA.; Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA, USA., Han GW; Bridge Institute, USC Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA, USA.; Department of Chemistry, University of Southern California, Los Angeles, CA, USA., Lam JH; Bridge Institute, USC Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA, USA.; Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA, USA., Katritch V; Bridge Institute, USC Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA, USA.; Department of Chemistry, University of Southern California, Los Angeles, CA, USA.; Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA, USA., Cherezov V; Bridge Institute, USC Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA, USA.; Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.; Department of Chemistry, University of Southern California, Los Angeles, CA, USA., Gati C; Bridge Institute, USC Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA, USA. gati@usc.edu.; Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA. gati@usc.edu.; Department of Chemistry, University of Southern California, Los Angeles, CA, USA. gati@usc.edu.

Publikováno v: Nature [Nature] 2022 Aug; Vol. 608 (7921), pp. E15.

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Overturning the Peribysin Family Natural Products Isolated from Periconia byssoides OUPS-N133: Synthesis and Stereochemical Revision of Peribysins A, B, C, F, and G.

Autor: Athawale PR; Organic Chemistry Division, CSIR-National Chemical Laboratory, Pune 411008, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Kalmode HP; Organic Chemistry Division, CSIR-National Chemical Laboratory, Pune 411008, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Motiwala Z; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.; Biochemical Sciences Division, CSIR-National Chemical Laboratory, Pune 411008, India., Kulkarni KA; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.; Biochemical Sciences Division, CSIR-National Chemical Laboratory, Pune 411008, India., Reddy DS; Organic Chemistry Division, CSIR-National Chemical Laboratory, Pune 411008, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.

Publikováno v: Organic letters [Org Lett] 2020 Apr 17; Vol. 22 (8), pp. 3104-3109. Date of Electronic Publication: 2020 Apr 07.