Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Mothukuri Ganesh Kumar"'
Autor:
Habeshian, Sevan, Merz, Manuel Leonardo, Sangouard, Gontran, Mothukuri, Ganesh Kumar, Schüttel, Mischa, Bognár, Zsolt, Díaz-Perlas, Cristina, Vesin, Jonathan, Bortoli Chapalay, Julien, Turcatti, Gerardo, Cendron, Laura, Angelini, Alessandro, Heinis, Christian
Macrocycles have excellent potential as therapeutics due to their ability to bind challenging targets. However, generating macrocycles against new targets is hindered by a lack of large macrocycle libraries for high-throughput screening. To overcome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::048daad1467d5a487d6e7712be123622
http://hdl.handle.net/10278/3762388
http://hdl.handle.net/10278/3762388
Publikováno v:
The Journal of organic chemistry. 84(23)
Here, we are reporting a single-step transformation of N-protected α,β-unsaturated γ-amino amides into 5,5-disubstituted γ-lactams through a base-mediated new molecular rearrangement. In contrast to the known N- to C(O) cyclization of saturated
Publikováno v:
Langmuir : the ACS journal of surfaces and colloids. 34(4)
Designing peptide-based drugs to target the β-sheet-rich toxic intermediates during the aggregation of amyloid-β 1-42 (Aβ1-42) has been a major challenge. In general, β-sheet breaker peptides (BSBPs) are designed to complement the enthalpic inter
Autor:
Mothukuri Ganesh Kumar, Rupal D. Bhaisare, Anindita Adak, Varsha J. Thombare, Hosahudya N. Gopi
Publikováno v:
European Journal of Organic Chemistry. 2015:135-141
A facile synthesis of highly symmetrical tetrasubstituted pyrazines through simple aerial oxidation of β-keto γ-amino esters is reported. The scope of the reaction was examined by use of various amino acid side-chain functional groups and peptides.
Publikováno v:
Chemical Communications. 51:13397-13399
Utilization of conjugated double bonds to engineer the novel folded miniature β-meander type structures, single step transformation of miniature β-meanders into ααγ(4)-hybrid peptide 10/12-helices using catalytic hydrogenation, their solution an
Autor:
Kuruva Veeresh, Mona M. Katariya, Varsha J. Thombare, Mothukuri Ganesh Kumar, Hosahudya N. Gopi, K. Muruga Poopathi Raja
Publikováno v:
Angewandte Chemie (International ed. in English). 55(27)
The impact of geometrically constrained cis α,β-unsaturated γ-amino acids on the folding of α,γ-hybrid peptides was investigated. Structure analysis in single crystals and in solution revealed that the cis carbon-carbon double bonds can be accom
Publikováno v:
Biopolymers. 108:e22978
β-Hydroxy-γ-amino acids (Statines) are a class of naturally occurring non-ribosomal amino acids frequently found in many peptide natural products. Peptidomimetics constituted with statines have been used as inhibitors for various aspartic acid prot
Publikováno v:
Organic letters. 17(2)
The synthesis and utilization of novel thiostatines (β-SH-substituted γ-amino acids) in the design of backbone-disulfide-stabilized β-hairpin mimetics, solution conformations of hybrid β-hairpins and Cys-disulfide-stabilized α-peptide analogue,
Publikováno v:
Organicbiomolecular chemistry. 12(42)
HBTU is a standard coupling agent commonly used for the activation of free carboxylic acids during the solution and solid phase peptide synthesis. 1-Hydroxybenzotriazole (HOBt) plays a significant role in reducing the racemization during peptide synt
Publikováno v:
Organic letters. 16(1)
The synthesis and characterization of syn and anti β-hydroxy γ-amino acid (statine) diastereoisomers, their utilization in the design of hybrid peptide foldamers, and their single crystal conformations are studied.