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pro vyhledávání: '"Mothukuri Ganesh Kumar"'
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Publikováno v:
The Journal of organic chemistry. 84(23)
Here, we are reporting a single-step transformation of N-protected α,β-unsaturated γ-amino amides into 5,5-disubstituted γ-lactams through a base-mediated new molecular rearrangement. In contrast to the known N- to C(O) cyclization of saturated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79833a15915f2000081ce124bcbf65b
https://pubmed.ncbi.nlm.nih.gov/31657563
https://pubmed.ncbi.nlm.nih.gov/31657563
Publikováno v:
Langmuir : the ACS journal of surfaces and colloids. 34(4)
Designing peptide-based drugs to target the β-sheet-rich toxic intermediates during the aggregation of amyloid-β 1-42 (Aβ1-42) has been a major challenge. In general, β-sheet breaker peptides (BSBPs) are designed to complement the enthalpic inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3467d50bb74940a28c968638f76d9a1
https://pubmed.ncbi.nlm.nih.gov/29284085
https://pubmed.ncbi.nlm.nih.gov/29284085
Autor:
Mothukuri Ganesh Kumar, Rupal D. Bhaisare, Anindita Adak, Varsha J. Thombare, Hosahudya N. Gopi
Publikováno v:
European Journal of Organic Chemistry. 2015:135-141
A facile synthesis of highly symmetrical tetrasubstituted pyrazines through simple aerial oxidation of β-keto γ-amino esters is reported. The scope of the reaction was examined by use of various amino acid side-chain functional groups and peptides.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0ee5c40fb75cb593f615eaf15f0098a
https://doi.org/10.1002/ejoc.201403237
https://doi.org/10.1002/ejoc.201403237
Publikováno v:
Chemical Communications. 51:13397-13399
Utilization of conjugated double bonds to engineer the novel folded miniature β-meander type structures, single step transformation of miniature β-meanders into ααγ(4)-hybrid peptide 10/12-helices using catalytic hydrogenation, their solution an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72cf42ee9b400a46223b2865bab56ce3
https://doi.org/10.1039/c5cc04523a
https://doi.org/10.1039/c5cc04523a
Autor:
Kuruva Veeresh, Mona M. Katariya, Varsha J. Thombare, Mothukuri Ganesh Kumar, Hosahudya N. Gopi, K. Muruga Poopathi Raja
Publikováno v:
Angewandte Chemie (International ed. in English). 55(27)
The impact of geometrically constrained cis α,β-unsaturated γ-amino acids on the folding of α,γ-hybrid peptides was investigated. Structure analysis in single crystals and in solution revealed that the cis carbon-carbon double bonds can be accom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::266d11da741af0a0ad2e7260fe6f9064
https://pubmed.ncbi.nlm.nih.gov/27271202
https://pubmed.ncbi.nlm.nih.gov/27271202
Publikováno v:
Biopolymers. 108:e22978
β-Hydroxy-γ-amino acids (Statines) are a class of naturally occurring non-ribosomal amino acids frequently found in many peptide natural products. Peptidomimetics constituted with statines have been used as inhibitors for various aspartic acid prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f11fe37233c28101d47600745171d0
https://doi.org/10.1002/bip.22978
https://doi.org/10.1002/bip.22978
Publikováno v:
Organic letters. 17(2)
The synthesis and utilization of novel thiostatines (β-SH-substituted γ-amino acids) in the design of backbone-disulfide-stabilized β-hairpin mimetics, solution conformations of hybrid β-hairpins and Cys-disulfide-stabilized α-peptide analogue,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3d7c756df09e8a5023c06f04a17fb8d
https://pubmed.ncbi.nlm.nih.gov/25539189
https://pubmed.ncbi.nlm.nih.gov/25539189
Publikováno v:
Organicbiomolecular chemistry. 12(42)
HBTU is a standard coupling agent commonly used for the activation of free carboxylic acids during the solution and solid phase peptide synthesis. 1-Hydroxybenzotriazole (HOBt) plays a significant role in reducing the racemization during peptide synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b056b6f55616a7b3e14a89dc8aad5cda
https://pubmed.ncbi.nlm.nih.gov/25228027
https://pubmed.ncbi.nlm.nih.gov/25228027
Publikováno v:
Organic letters. 16(1)
The synthesis and characterization of syn and anti β-hydroxy γ-amino acid (statine) diastereoisomers, their utilization in the design of hybrid peptide foldamers, and their single crystal conformations are studied.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::707e371359b08fc2f45e363cc368a0f8
https://pubmed.ncbi.nlm.nih.gov/24320892
https://pubmed.ncbi.nlm.nih.gov/24320892