Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Motahareh Mortazavi"'
Autor:
Motahareh Mortazavi, Masoomeh Eskandari, Fatemeh Moosavi, Tahereh Damghani, Mehdi Khoshneviszadeh, Somayeh Pirhadi, Luciano Saso, Najmeh Edraki, Omidreza Firuzi
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Oncogenic activation of receptor tyrosine kinases (RTKs) such as MET is associated with cancer initiation and progression. We designed and synthesized a new series of quinazoline derivatives bearing 1,2,3-triazole moiety as targeted anticanc
Externí odkaz:
https://doaj.org/article/c1443f8e9a85470f9474abe6d0ecf7b6
Autor:
Motahareh Mortazavi, Masoumeh Divar, Tahereh Damghani, Fatemeh Moosavi, Luciano Saso, Somayeh Pirhadi, Mehdi Khoshneviszadeh, Najmeh Edraki, Omidreza Firuzi
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
The advent of novel receptor tyrosine kinase inhibitors has provided an important therapeutic tool for cancer patients. In this study, a series of quinazolinone hydrazide triazole derivatives were designed and synthesized as novel MET (c-MET) recepto
Externí odkaz:
https://doaj.org/article/cf100fbfe3654206af7467a5ea561e43
Autor:
Tahereh Damghani, Fatemeh Moosavi, Mehdi Khoshneviszadeh, Motahareh Mortazavi, Somayeh Pirhadi, Zahra Kayani, Luciano Saso, Najmeh Edraki, Omidreza Firuzi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Abstract Aberrant activation of c-Met signalling plays a prominent role in cancer development and progression. A series of 12 imidazo [1,2-α] pyridine derivatives bearing 1,2,3-triazole moiety were designed, synthesized and evaluated for c-Met inhib
Externí odkaz:
https://doaj.org/article/e84ba50f01d64642a71fc85adbc1b611
Autor:
Hooshang Rafighdoust, Amaneh Mohammadi Roushandeh, Shirin Darabi, Motahareh Mortazavi, Amir Rafighdoust
Publikováno v:
Anatomical Sciences Journal, Vol 11, Iss 4, Pp 183-188 (2014)
Introduction: Cardiac glycosides such as digoxin or digitoxin are the natural products that are traditionally used to increase cardiac contractile force in patients with heart failure and cardiac arrhythmias. It has been shown that digoxin can direct
Externí odkaz:
https://doaj.org/article/b2d5280b6eae4b2a867cc8350d942eac
Autor:
Motahareh Mortazavi, Mehryar Habibi Roudkenar, Abbas Delazar, Raheleh Halabian, Sara Ansari, Zohreh Alizadeh, Amaneh Mohammadi Roushandeh
Publikováno v:
Basic & Clinical Cancer Research, Vol 4, Iss 1&2 (2013)
Background: Herbal medicine is a new complementary strategy for treating diseases such as cancer. However, its mechanism of action is not clear yet. This study investigates antitumor efficacy of Polygonum avicular extract on MCF-7 cell line. Methods:
Externí odkaz:
https://doaj.org/article/be91e8f0406f49558974452d878a1d20
Autor:
Motahareh, Mortazavi, Elaheh, Raufi, Tahereh, Damghani, Mehdi, Khoshneviszadeh, Najmeh, Edraki, Masoomeh, Eskandari, Elisa, Giovannetti, Godefridus J, Peters, Somayeh, Pirhadi, Omidreza, Firuzi
Publikováno v:
European Journal of Pharmacology, 938:175395. Elsevier
Mortazavi, M, Raufi, E, Damghani, T, Khoshneviszadeh, M, Edraki, N, Eskandari, M, Giovannetti, E, Peters, G J, Pirhadi, S & Firuzi, O 2023, ' Discovery of anticancer agents with c-Met inhibitory potential by virtual and experimental screening of a chemical library ', European Journal of Pharmacology, vol. 938, 175395 . https://doi.org/10.1016/j.ejphar.2022.175395
Mortazavi, M, Raufi, E, Damghani, T, Khoshneviszadeh, M, Edraki, N, Eskandari, M, Giovannetti, E, Peters, G J, Pirhadi, S & Firuzi, O 2023, ' Discovery of anticancer agents with c-Met inhibitory potential by virtual and experimental screening of a chemical library ', European Journal of Pharmacology, vol. 938, 175395 . https://doi.org/10.1016/j.ejphar.2022.175395
c-Met receptor tyrosine kinase has recently emerged as an important target with therapeutic implications in pancreatic cancer. In this study, we carried out a docking virtual screening on an in-house library of 441 synthesized compounds and selected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::089ce2b33156cdf9dd873c90dd6d289d
http://www.scopus.com/inward/record.url?scp=85143162338&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85143162338&partnerID=8YFLogxK
Autor:
Motahareh, Mortazavi, Fatemeh, Moosavi, Miriam, Martini, Elisa, Giovannetti, Omidreza, Firuzi
Publikováno v:
Mortazavi, M, Moosavi, F, Martini, M, Giovannetti, E & Firuzi, O 2022, ' Prospects of targeting PI3K/AKT/mTOR pathway in pancreatic cancer ', Critical Reviews in Oncology/Hematology, vol. 176, 103749 . https://doi.org/10.1016/j.critrevonc.2022.103749
Pancreatic ductal adenocarcinoma (PDAC) has one of the worst prognoses among all malignancies. PI3K/AKT/mTOR signaling pathway, a main downstream effector of KRAS is involved in the regulation of key hallmarks of cancer. We here report that whole-gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4ac1d88e3e3e31c06b4e8109a0c6cfc
https://doi.org/10.1016/j.critrevonc.2022.103749
https://doi.org/10.1016/j.critrevonc.2022.103749
Autor:
Najmeh Edraki, Tahereh Damghani, Motahareh Mortazavi, Zahra Kayani, Mehdi Khoshneviszadeh, Fatemeh Moosavi, Luciano Saso, Omidreza Firuzi, Somayeh Pirhadi
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Aberrant activation of c-Met signalling plays a prominent role in cancer development and progression. A series of 12 imidazo [1,2-α] pyridine derivatives bearing 1,2,3-triazole moiety were designed, synthesized and evaluated for c-Met inhibitory pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba8fbc96341b4f6c2cf8cd0973e02b5
http://europepmc.org/articles/PMC7878917
http://europepmc.org/articles/PMC7878917
Autor:
Sadegh Zarei, Nasrin Ziamajidi, Hemen Moradi, Motahareh Mortazavi, Soheila Asadi, Roghayeh Abbasalipourkabir, Aref Salehzadeh, Abolfazl Ghafourikhosroshahi
Publikováno v:
Food and Chemical Toxicology. 84:154-160
The purpose of this study was to investigate the effects of zinc oxide nanoparticles (nZnO) on adult male Wistar rats. Thirty male Wistar rats divided into five groups of six animals each were used for this study. For ten days, Groups one to four con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ad284d34298f783fc57bef5f610971a
https://doi.org/10.1016/j.fct.2015.08.019
https://doi.org/10.1016/j.fct.2015.08.019
Autor:
Rozbeh Farhadian, Amaneh Mohammadi Roushandeh, Zahra Azarifar, Motahareh Mortazavi, Soraya Parvari
Publikováno v:
Pharmaceutical Sciences. 21:41-45
Background: Progressive incidence of cervical cancer persuaded the scientists to find the most effective and appropriate treatment approaches such as herbal medicine. Hence, it was aimed in this study to evaluate antitumoral effects of Purtulaca oler
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2035ef94546f44baefe987325b52618
https://doi.org/10.15171/ps.2015.15
https://doi.org/10.15171/ps.2015.15