Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Motahareh Arjomandnejad"'
Autor:
Motahareh Arjomandnejad, Katelyn Sylvia, Meghan Blackwood, Thomas Nixon, Qiushi Tang, Manish Muhuri, Alisha M. Gruntman, Guangping Gao, Terence R. Flotte, Allison M. Keeler
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss , Pp 490-506 (2021)
Immune responses to adeno-associated virus (AAV) capsids limit the therapeutic potential of AAV gene therapy. Herein, we model clinical immune responses by generating AAV capsid-specific chimeric antigen receptor (AAV-CAR) T cells. We then modulate i
Externí odkaz:
https://doaj.org/article/1d3794b4a1154ad0b895efd390f57d2a
Autor:
Manish Muhuri, Wei Zhan, Yukiko Maeda, Jia Li, Anoushka Lotun, Jennifer Chen, Katelyn Sylvia, Ishani Dasgupta, Motahareh Arjomandnejad, Thomas Nixon, Allison M. Keeler, Sangeetha Manokaran, Ran He, Qin Su, Phillip W. L. Tai, Guangping Gao
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Recombinant adeno-associated virus (rAAV) platforms hold promise for in vivo gene therapy but are undermined by the undesirable transduction of antigen presenting cells (APCs), which in turn can trigger host immunity towards rAAV-expressed transgene
Externí odkaz:
https://doaj.org/article/01510ca4e9254713881c8470321ee966
Publikováno v:
Biomedicines, Vol 10, Iss 2, p 287 (2022)
Regulatory T cells are critical for maintaining immune tolerance. Recent studies have confirmed their therapeutic suppressive potential to modulate immune responses in organ transplant and autoimmune diseases. However, the unknown and nonspecific ant
Externí odkaz:
https://doaj.org/article/866573c17b8e4b23938c0829a2932558
Autor:
Tahereh Barati, Mahnaz Haddadi, Fatemeh Sadeghi, Samad Muhammadnejad, Ahad Muhammadnejad, Ronak Heidarian, Motahareh Arjomandnejad, Saeid Amanpour
Publikováno v:
Iranian Journal of Basic Medical Sciences, Vol 21, Iss 7, Pp 678-681 (2018)
Objective(s): Gastric cancer is the third leading cause of cancer-related death worldwide. The overall survival rate of patients is poor because gastric cancers are usually diagnosed at the late stages. Therefore, further research is needed and appro
Externí odkaz:
https://doaj.org/article/516adbcc73ca4bf8885511a2210a641c
Autor:
Fariba Sadeghi Fazel, Mahnaz Haddadi, Alireza Khoshnevisan, Samad Muhammadnejad, Ahad Muhammadnejad, Zohreh Mazaheri, Motahareh Arjomandnejad, Reza Shirkoohi, Mohammad-Ali Oghabian, Narjes Sherkat-Khameneh, Saeid Amanpour, Monireh Kazemimanesh
Publikováno v:
Iranian Journal of Basic Medical Sciences, Vol 17, Iss 11, Pp 922-925 (2014)
Objective(s):P In vitro chemosensitivity and resistance assays (CSRAs) are a promising tool for personalized treatment of glioblastoma multiform (GBM). These assays require a minimum of 1 to 2 g of tumor specimen for testing, but this amount is not a
Externí odkaz:
https://doaj.org/article/bf16c6dfd2da4ceba5470f29cb87eb0f
Publikováno v:
BioDrugs. 37:311-329
Autor:
Abigail McElroy, Miguel Sena-Esteves, Motahareh Arjomandnejad, Allison M. Keeler, Heather L. Gray-Edwards
Publikováno v:
Human Gene Therapy. 33:889-892
Adeno-associated virus (AAV)-mediated gene therapies have provided promising treatments for numerous neurological disorders. Redosing of AAV to the central nervous system (CNS) is an attractive research area due to both the somewhat immunologically p
Autor:
Thomas Nixon, Alisha M. Gruntman, Manish Muhuri, Katelyn Sylvia, Qiushi Tang, Meghan Blackwood, Motahareh Arjomandnejad, Terence R. Flotte, Guangping Gao, Allison M. Keeler
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss, Pp 490-506 (2021)
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss, Pp 490-506 (2021)
Immune responses to adeno-associated virus (AAV) capsids limit the therapeutic potential of AAV gene therapy. Herein, we model clinical immune responses by generating AAV capsid-specific chimeric antigen receptor (AAV-CAR) T cells. We then modulate i
Publikováno v:
Human Gene Therapy. 33:218-220
Publikováno v:
Biomedicines. 10(2)
Regulatory T cells are critical for maintaining immune tolerance. Recent studies have confirmed their therapeutic suppressive potential to modulate immune responses in organ transplant and autoimmune diseases. However, the unknown and nonspecific ant