Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Mostafa M.M. El-Miligy"'
Autor:
Mai S. El-Shoukrofy, Mohamed A Abdelsalam, El-Sayed A. M. Badawey, Noha Gouda, Omaima M. Aboulwafa, Mostafa M.M. El-Miligy
Publikováno v:
Future Medicinal Chemistry. 10:2791-2814
Aim: Some anticancer β-carbolines exhibited dual inhibition of topo-I and KSP. Methodology/Results: Novel β-carbolines were synthesized and screened for their anticancer activity according to the NCI protocol. Five dose assays results indicated tha
Autor:
Marwa M. Abu-Serie, Ahmed K. Al-Kubeisi, Mostafa M.M. El-Miligy, Saad R. El-Zemity, Aly A. Hazzaa, Rasha A. Nassra
Publikováno v:
Bioorganic chemistry. 115
Colorectal cancer (CRC) is the second cause of cancer death worldwide. Inhibitors of COX-2, 5-LOX and PIM-1 kinase were very effective in the treatment and prevention of CRC in mouse models in vivo. Furthermore, thymol was confirmed to inhibit CRC ce
Publikováno v:
Bioorganic Chemistry. 80:674-692
A series of pyridine and thieno[2,3-b]pyridine derivatives have been designed and synthesized as anticancer PIM-1 kinase inhibitors. Thirty-seven compounds were selected by NCI to be tested initially at a single dose (10 µM) in the full NCI 60 cell
Autor:
Omaima M. Aboulwafa, Mahmoud M. Elaasser, Mai S. El-Shoukrofy, Mohamed A Abdelsalam, El-Sayed A. M. Badawey, Mostafa M.M. El-Miligy, Noha Gouda
Publikováno v:
Future medicinal chemistry. 10(10)
Background: Medicinal interest has focused on β-carbolines as anticancer agents. Methodology/Results: Several β-carbolines were designed, synthesized and evaluated for their cytotoxic activity against MCF-7 and A-549 cancer cell lines using MTT ass
Autor:
Mostafa M.M. El-Miligy, Alaa El-Din A. Bekhit, Adnan A. Bekhit, Heba A. Abd El Razik, Eman J. El-Agroudy, Ahmed M. M. Hassan
Publikováno v:
European Journal of Medicinal Chemistry. 94:30-44
A new series of pyrazole derivatives were synthesized by hybridization with five-membered heterocyclic moieties such as thiazoles, thiazolidinones, 1,3,4-thiadiazoles and pyrazolines. The compounds were evaluated for their in vivo antimalarial activi
Publikováno v:
Future medicinal chemistry. 9(15)
Aim: VEGFR2 tyrosine kinase is a main target in suppressing cancer growth and metastasis. Materials & methods: Piperazine-based thiazolidinones were synthesized and screened for their anticancer and VEGFR2 tyrosine kinase inhibitory activity. Results
Autor:
S. M. Rida, Fawzia A. Ashour, Mostafa M.M. El-Miligy, Ehab M El-Bassiony, Mona H. Badr, Ashraf M Omar, Maha A El-Demellawy
Publikováno v:
Future Science OA
Aim: Simultaneous inhibition of hepatitis C virus (HCV) and hepatocellular carcinoma (HCC) may enhance anti-HCV effects and reduce resistance and side effects. Results/methodology: Novel hybrid derivatives were designed and synthesized to exhibit dua
Autor:
Soad A.M. El-Hawash, Rasha A. Nassra, Mostafa M.M. El-Miligy, Hanan El-Messmary, Aly A. Hazzaa
Publikováno v:
Future medicinal chemistry. 9(5)
Aim: Simultaneous inhibition of 5-LOX/COX may enhance anti-inflammatory effects and reduce side effects. Hence, synthesis of novel dual inhibitors of 5-LOX/COX is an important strategy for treatment of inflammation. Results/methodology: The target co
Autor:
Mostafa M.M. El-Miligy, Soad A.M. El-Hawash, Aly A. Hazzaa, Hanan El-Messmary, Rasha A. Nassra
Publikováno v:
Bioorganic chemistry. 72
New molecular hybrids combining benzothiophene or its bioisostere benzofuran with rhodanine were synthesized as potential dual COX-2/5-LOX inhibitors. The benzothiophene or benzofuran scaffold was linked at position -2 with rhodanine which was furthe