Zobrazeno 1 - 10
of 229
pro vyhledávání: '"Mostafa E, Rateb"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Pim-1 kinase, a serine/threonine kinase, is often overexpressed in various cancers, contributing to disease progression and poor prognosis. In this study, we explored the potential of flavonoids as inhibitors of Pim-1 kinase using a combination of mo
Externí odkaz:
https://doaj.org/article/73003b78ccc841698e8bacd0bcd1ca8c
Autor:
Norhan H. Mahdally, Abdalla E. M. Salih, Riham A. El-Shiekh, Ahmed M. Sayed, Noha M. Elhosseiny, Mona T. Kashef, Mohammed Yaseen, William Mackay, Ali M. El Halawany, Mostafa E. Rateb, Ahmed S. Attia
Publikováno v:
Future Journal of Pharmaceutical Sciences, Vol 10, Iss 1, Pp 1-15 (2024)
Abstract Background The infamous multidrug-resistant (MDR) bacterium Acinetobacter baumannii is becoming a nightmare in intensive care units across the globe. Since there are now very few effective antimicrobial agents, it is necessary to explore unc
Externí odkaz:
https://doaj.org/article/e8756fdb22be4f9fafec6d4c254957a8
Autor:
Sultan Aati, Hanan O. Farouk, Marwa H. Elkarmalawy, Hanan Y. Aati, Nahla Sameh Tolba, Hossam M. Hassan, Mostafa E. Rateb, Doaa S. Hamad
Publikováno v:
Pharmaceutics, Vol 16, Iss 11, p 1432 (2024)
Background: Itraconazole (ITZ) is an antiangiogenic agent recognized as a potent suppressor of endothelial cell growth that suppresses angiogenesis. Nevertheless, its exploitation is significantly restricted by its low bioavailability and systematic
Externí odkaz:
https://doaj.org/article/ec6f5b0447fd4d0f80bb30233e544a4d
Autor:
Abeer H. Elmaidomy, Amr El Zawily, Aliasger K. Salem, Faisal H. Altemani, Naseh A. Algehainy, Abdullah H. Altemani, Mostafa E. Rateb, Usama Ramadan Abdelmohsen, Nourhan Hisham Shady
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Cancer is the world's second-leading cause of death. Drug development efforts frequently focus on medicinal plants since they are a valuable source of anticancer medications. A phytochemical investigation of the edible Ziziphus spina-christi
Externí odkaz:
https://doaj.org/article/2fe1287bf2e04239b67de792bf03f892
Autor:
Heba A. S. El-Nashar, Ahmed M. Sayed, Hany A. M. El-Sherief, Mostafa E. Rateb, Lina Akil, Ibrahim Khadra, Taghreed A. Majrashi, Sara T. Al-Rashood, Faizah A. Binjubair, Mahmoud A. El Hassab, Wagdy M. Eldehna, Usama Ramadan Abdelmohsen, Nada M. Mostafa
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Trypanosomiasis is a protozoan disease transmitted via Trypanosoma brucei. This study aimed to examine the metabolic profile and anti-trypanosomal effect of methanol extract of Thunbergia grandifolia leaves. The liquid chromatography-high resolution
Externí odkaz:
https://doaj.org/article/c8b387b2f8eb4d3fb519dee9f7f66dd0
Autor:
Mohammed H. Elkomy, Hussein M. Eid, Mohammed Elmowafy, Khaled Shalaby, Ameeduzzafar Zafar, Mohamed A. Abdelgawad, Mostafa E. Rateb, Mohammed R.A. Ali, Izzeddin Alsalahat, Heba A. Abou-Taleb
Publikováno v:
Drug Delivery, Vol 29, Iss 1, Pp 2694-2704 (2022)
Diabetes mellitus is a life-threatening metabolic disease. At the moment, there is no effective treatment available to combat it. In this study, we aimed to develop berberine-loaded bilosomes (BER-BLS) to boost the oral bioavailability and therapeuti
Externí odkaz:
https://doaj.org/article/5b91575a0920404994b717c00dbbd534
Publikováno v:
Encyclopedia, Vol 2, Iss 3, Pp 1590-1601 (2022)
Fungi produce a wide range of secondary metabolites. Some of these metabolites are toxic to humans and cause various health disorders, ranging from acute poisoning to chronic diseases. Contrary to this, some fungal metabolites are valuable sources in
Externí odkaz:
https://doaj.org/article/0e4f61d2aa904ad7bcdc7f2b0c4e8e74
Autor:
Hani A. Alhadrami, Ahmed S.G. Srag El-Din, Hossam M. Hassan, Ahmed M. Sayed, Albaraa H. Alhadrami, Mostafa E. Rateb, Demiana M. Naguib
Publikováno v:
Pharmaceutics, Vol 15, Iss 11, p 2531 (2023)
This study aimed to develop a self-nanoemulsifying drug delivery system (SNE) for sinapic acid (SA) to improve its solubility and antiviral activity. Optimal components for the SA-SNE formulation were selected, including Labrafil as the oil, Cremopho
Externí odkaz:
https://doaj.org/article/afa0e0769a87453a918c35296946c205
Autor:
Mohammed H. Elkomy, Randa Mohammed Zaki, Omar A. Alsaidan, Mohammed Elmowafy, Ameeduzzafar Zafar, Khaled Shalaby, Mohamed A. Abdelgawad, Fatma I. Abo El-Ela, Mostafa E. Rateb, Ibrahim A. Naguib, Hussein M. Eid
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 1805 (2023)
Numerous neurological disorders have a pathophysiology that involves an increase in free radical production in the brain. Quercetin (QER) is a nutraceutical compound that shields the brain against oxidative stress-induced neurodegeneration. Nonethele
Externí odkaz:
https://doaj.org/article/25da909f42b8458db6aeafa901b0e343
Autor:
Hani A. Alhadrami, Ahmed M. Sayed, Ahmed O. El-Gendy, Yara I. Shamikh, Yasser Gaber, Walid Bakeer, Noheir H. Sheirf, Eman Z. Attia, Gehan M. Shaban, Basma A. Khalifa, Che J. Ngwa, Gabriele Pradel, Mostafa E. Rateb, Hossam M. Hassan, Dalal H. M. Alkhalifah, Usama Ramadan Abdelmohsen, Wael N. Hozzein
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Fungal endophytes are a major source of anti-infective agents and other medically relevant compounds. However, their classical blinded-chemical investigation is a challenging process due to their highly complex chemical makeup. Thus, utilizi
Externí odkaz:
https://doaj.org/article/29b0b93f8e0d4cd3a83720981824c6be