Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Mossy cell"'
Publikováno v:
eLife, Vol 12 (2024)
Abnormal cellular and circuit excitability is believed to drive many core phenotypes in fragile X syndrome (FXS). The dentate gyrus is a brain area performing critical computations essential for learning and memory. However, little is known about den
Externí odkaz:
https://doaj.org/article/c2a91812bf7b41a9a3c16977a974f3d6
Autor:
Laura Mundrucz, Angéla Kecskés, Nóra Henn-Mike, Péter Kóbor, Péter Buzás, Rudi Vennekens, Miklós Kecskés
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-12 (2023)
Abstract Background Mossy cells comprise a large fraction of excitatory neurons in the hippocampal dentate gyrus, and their loss is one of the major hallmarks of temporal lobe epilepsy (TLE). The vulnerability of mossy cells in TLE is well known in a
Externí odkaz:
https://doaj.org/article/2fa58a8e8bb1442582ab107ed173e007
Publikováno v:
eLife, Vol 12 (2023)
Epileptic seizures induce aberrant neurogenesis from resident neural stem cells (NSCs) in the dentate gyrus of the adult mouse hippocampus, which has been implicated in depletion of the NSC pool and impairment of hippocampal function. However, the me
Externí odkaz:
https://doaj.org/article/387e040842194f7197f575e707228a58
Publikováno v:
Neurobiology of Disease, Vol 187, Iss , Pp 106311- (2023)
Hippocampal oxytocin receptor (OXTR) signaling is crucial for discrimination of social stimuli to guide social recognition, but circuit mechanisms and cell types involved remain incompletely understood. Here, we report a role for OXTR-expressing hila
Externí odkaz:
https://doaj.org/article/f346f313adc94710985b0f5878f9c145
Akademický článek
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Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Long-term potentiation and depression of NMDA receptor-mediated synaptic transmission (NMDAR LTP/LTD) can significantly impact synapse function and information transfer in several brain areas. However, the mechanisms that determine the direction of N
Externí odkaz:
https://doaj.org/article/04facc65415b48b4b0941749226220ca
Akademický článek
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Autor:
Michael R. Grovola, Nicholas Paleologos, Kathryn L. Wofford, James P. Harris, Kevin D. Browne, Victoria Johnson, John E. Duda, John A. Wolf, D. Kacy Cullen
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-18 (2020)
Abstract Background Each year in the USA, over 2.4 million people experience mild traumatic brain injury (TBI), which can induce long-term neurological deficits. The dentate gyrus of the hippocampus is notably susceptible to damage following TBI, as
Externí odkaz:
https://doaj.org/article/f8323c6205b348998cb2767d10d6535b
Autor:
Kai-Yi Wang, Jei-Wei Wu, Jen-Kun Cheng, Chun-Chung Chen, Wai-Yi Wong, Robert G. Averkin, Gábor Tamás, Kazu Nakazawa, Cheng-Chang Lien
Publikováno v:
Cell Reports, Vol 36, Iss 11, Pp 109702- (2021)
Summary: Modulation of hippocampal dentate gyrus (DG) excitability regulates anxiety. In the DG, glutamatergic mossy cells (MCs) receive the excitatory drive from principal granule cells (GCs) and mediate the feedback excitation and inhibition of GCs
Externí odkaz:
https://doaj.org/article/cb2cb002edfb4f8b8b677f6f9dcc0df7
Publikováno v:
Cell Reports, Vol 23, Iss 9, Pp 2541-2549 (2018)
The role of mossy cells (MCs) of the hippocampal dentate area has long remained mysterious. Recent research has begun to unveil their significance in spatial computation of the hippocampus. Here, we used an in vitro model of sharp wave-ripple complex
Externí odkaz:
https://doaj.org/article/3def3b54dcce48f29b2ceb1132522c05