Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Novel advances in biotransformation and bioactivation research – 2020 year in review

Autor: Khojasteh, S Cyrus, Argikar, Upendra A, Driscoll, James P, Heck, Carley JS, King, Lloyd, Jackson, Klarissa D, Jian, Wenying, Kalgutkar, Amit S, Miller, Grover P, Kramlinger, Valerie, Rietjens, Ivonne MCM, Teitelbaum, Aaron M, Wang, Kai, Wei, Cong, Johnson, Benjamin M, Shu, Yue-Zhong, Zhuo, Xiaoliang, Meanwell, Nicholas A, Cerny, Matthew A, Obach, R Scott, Sharma, Raman, Spracklin, Douglas K, Walker, Gregory S, Goracci, Laura, Desantis, Jenny, Valeri, Aurora, Castellani, Beatrice, Eleuteri, Michela, Cruciani, Gabriele, Lall, Manjinder S, Bassyouni, Asser, Bradow, James, Brown, Maria, Bundesmann, Mark, Chen, Jinshan, Ciszewski, Gregory, Hagen, Anne E, Hyek, Dennis, Jenkinson, Stephen, Liu, Bo, Pan, Senliang, Reilly, Usa, Sach, Neal, Smaltz, Daniel J, Starr, Jeremy, Wagenaar, Melissa, de Bruyn Kops, Christina, Sicho, Martin, Mazzolari, Angelica, Kirchmair, Johannes, Korprasertthaworn, Porntipa, Chau, Nuy, Nair, Pramod C, Rowland, Andrew, Miners, John O, Wrobleski, Stephen T, Moslin, Ryan, Lin, Shuqun, Zhang, Yanlei, Spergel, Steven, Kempson, James, Tokarski, John S, Strnad, Joann, Zupa-Fernandez, Adriana, Cheng, Lihong, Shuster, David, Gillooly, Kathleen, Yang, Xiaoxia, Heimrich, Elizabeth, McIntyre, Kim W, Chaudhry, Charu, Khan, Javed, Ruzanov, Max, Tredup, Jeffrey, Mulligan, Dawn, Xie, Dianlin, Sun, Huadong, Huang, Christine, D'Arienzo, Celia, Aranibar, Nelly, Chiney, Manoj, Chimalakonda, Anjaneya, Pitts, William J, Lombardo, Louis, Carter, Percy H, Burke, James R, Weinstein, David S, Li, Jing, Liu, Ju, Enders, Jennifer, Arciprete, Michael, Tran, Chris, Aluri, Krishna, Guan, Li-Hua, O'Shea, Jonathan, Bisbe, Anna, Charisse, Klaus, Zlatev, Ivan, Najarian, Diana, Xu, Yuanxin, Kim, Jaeah, El Zahar, Noha M, Bartlett, Michael G, Katyayan, Kishore, Yi, Ping, Monk, Scott, Cassidy, Kenneth, Takahashi, Ryan H, Grandner, Jessica M, Bobba, Sudheer, Liu, Yanzhou, Beroza, Paul, Zhang, Donglu, Ma, Shuguang, Post, Noah, Yu, Rosie, Greenlee, Sarah, Gaus, Hans, Hurh, Eunju, Matson, John, Wang, Yanfeng, Tajima, Yuya, Toyoda, Takeshi, Hirayama, Yuichiro, Matsushita, Kohei, Yamada, Takanori, Ogawa, Kumiko, Watanabe, Kenji, Takamura-Enya, Takeji, Totsuka, Yukari, Wakabayashi, Keiji, Miyoshi, Noriyuki, Zhang, Jiayin, Chan, Chi-Kong, Ham, Yat-Hing, Chan, Wan, Schleiff, Mary Alexandra, Flynn, Noah R, Payakachat, Sasin, Schleiff, Benjamin Mark, Pinson, Anna O, Province, Dennis W, Swamidass, S Joshua, Boysen, Gunnar, Nardone-White, Dasean T, Bissada, Jennifer E, Abouda, Arsany A, Zhang, Zhuming, Connolly, Peter J, Lim, Heng Keang, Pande, Vineet, Meerpoel, Lieven, Teleha, Christopher, Branch, Jonathan R, Ondrus, Janine, Hickson, Ian, Bush, Tammy, Luistro, Leopoldo, Packman, Kathryn, Bischoff, James R, Ibrahim, Salam, Parrett, Christopher, Chong, Yolanda, Gottardis, Marco M, Bignan, Gilles, Mulder, Teresa, Bobba, Sudder, Johnson, Kevin M, Wang, Wei, Zhang, Chenghong, Cai, Jingwei, Choo, Edna F, Crawford, James J, Landry, Matthew L, Chen, Huifen, Kenny, Jane R, Lee, Wendy, Young, Wendy B, Geib, Timon, Thulasingam, Madhuranayaki, Haeggstrom, Jesper Z, Sleno, Lekha, Monroe, James J, Tanis, Keith Q, Podtelezhnikov, Alexei A, Nguyen, Truyen, Machotka, Sam V, Lynch, Donna, Evers, Raymond, Palamanda, Jairam, Miller, Randy R, Pippert, Todd, Cabalu, Tamara D, Johnson, Timothy E, Aslamkhan, Amy G, Kang, Wen, Tamburino, Alex M, Mitra, Kaushik, Agrawal, Nancy GB, Sistare, Frank D

Publikováno v: Drug Metabolism Reviews 53 (2021) 3
Drug Metabolism Reviews, 53(3), 384-433

This annual review is the sixth of its kind since 2016 (see references). Our objective is to explore and share articles which we deem influential and significant in the field of biotransformation and bioactivation. These fields are constantly evolvin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a22a3073b1b8be7c5621703d8a65f67
https://doi.org/10.1080/03602532.2021.1916028

Identification of N-Methyl Nicotinamide and N-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2)

Autor: Yanlei Zhang, Jeffrey Tredup, Mertzman Michael E, Nelly Aranibar, Kim W. McIntyre, Kathleen M. Gillooly, Jodi K. Muckelbauer, James R. Burke, Lihong Cheng, Joann Strnad, Celia D’Arienzo, Dawn Mulligan, Stephen T. Wrobleski, Charu Chaudhry, Adriana Zupa-Fernandez, Percy H. Carter, Dianlin Xie, Manoj Chiney, Elizabeth M. Heimrich, Moslin Ryan M, Christine Huang, Xiaoxia Yang, Shuqun Lin, David S. Weinstein, Tokarski John S, Chiehying Chang, Louis J. Lombardo, Huadong Sun, Steven H. Spergel

Publikováno v: Journal of Medicinal Chemistry. 62:8953-8972

As a member of the Janus (JAK) family of nonreceptor tyrosine kinases, TYK2 plays an important role in mediating the signaling of pro-inflammatory cytokines including IL-12, IL-23, and type 1 interferons. The nicotinamide 4, identified by a SPA-based

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ce72d9f5c30b5b21e9d4c5dd0ac4218
https://doi.org/10.1021/acs.jmedchem.9b00443

Directing effects of tethered alkenes in nickel-catalyzed coupling reactions of 1,6-enynes and aldehydes

Autor: Moslin, Ryan M., Miller, Karen M., Jamison, Timothy F.

Publikováno v: In Tetrahedron 2006 62(32):7598-7610

Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain

Autor: Jenny Xie, Sha Li, Adriana Zupa-Fernandez, Celia D’Arienzo, Xiaoxia Yang, Mark D. Cunningham, Moslin Ryan M, Xiadi Zhou, Kim W. McIntyre, Kathleen M. Gillooly, James R. Burke, Joann Strnad, Ian M. Catlett, Charu Chaudhry, Shawn M. Rose, Julie Carman, David S. Weinstein, Elizabeth M. Heimrich, Jinwen Huang, Luisa Salter-Cid, Jian Pang, Stephen T. Wrobleski, Dana Banas, Qihong Zhao, Lihong Cheng, Yifan Zhang, Anjaneya Chimalakonda

Publikováno v: Science Translational Medicine. 11

TYK2 is a nonreceptor tyrosine kinase involved in adaptive and innate immune responses. A deactivating coding variant has previously been shown to prevent receptor-stimulated activation of this kinase and provides high protection from several common

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5548473043f7e0b73a9eff8ff661ebb4
https://doi.org/10.1126/scitranslmed.aaw1736