High-affinity sigma-1 (σ 1 ) receptor ligands based on the σ 1 antagonist PB212.

Autor: Niso M; Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari ALDO MORO, Via Orabona 4, I-70125 Bari, Italy., Mosier PD; Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA., Marottoli R; Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari ALDO MORO, Via Orabona 4, I-70125 Bari, Italy., Ferorelli S; Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari ALDO MORO, Via Orabona 4, I-70125 Bari, Italy., Cassano G; Dipartimento di Bioscienze, Biotecnologie e Biofarmaceutica, Università degli Studi di Bari ALDO MORO, Via Orabona 4, I-70125 Bari, Italy., Gasparre G; Dipartimento di Bioscienze, Biotecnologie e Biofarmaceutica, Università degli Studi di Bari ALDO MORO, Via Orabona 4, I-70125 Bari, Italy., Leopoldo M; Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari ALDO MORO, Via Orabona 4, I-70125 Bari, Italy., Berardi F; Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari ALDO MORO, Via Orabona 4, I-70125 Bari, Italy., Abate C; Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari ALDO MORO, Via Orabona 4, I-70125 Bari, Italy.

Publikováno v: Future medicinal chemistry [Future Med Chem] 2019 Oct; Vol. 11 (19), pp. 2547-2562.

Discovery and Biochemical Characterization of PlyP56, PlyN74, and PlyTB40- Bacillus Specific Endolysins.

Autor: Etobayeva I; Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA. romani@ibbr.umd.edu.; Department of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA. romani@ibbr.umd.edu., Linden SB; Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA. slinden1@umd.edu., Alem F; School of Systems Biology and National Center for Biodefense & Infectious Diseases, Biomedical Research Laboratory, George Mason University, Manassas, VA 22030, USA. falem@masonlive.gmu.edu., Harb L; Department of Integrated Science & Technology, James Madison University, Harrisonburg, VA 22807, USA. harbla@tamu.edu., Rizkalla L; Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, VA 23220, USA. rizkallalj@mymail.vcu.edu., Mosier PD; Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, VA 23220, USA. pdmosier@vcu.edu.; Department of Medicinal Chemistry and Institute for Structural Biology, Drug Discovery and Development, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23220, USA. pdmosier@vcu.edu., Johnson AA; Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, VA 23220, USA. aajohnson@vcu.edu., Temple L; Department of Integrated Science & Technology, James Madison University, Harrisonburg, VA 22807, USA. templelm@jmu.edu., Hakami RM; School of Systems Biology and National Center for Biodefense & Infectious Diseases, Biomedical Research Laboratory, George Mason University, Manassas, VA 22030, USA. rhakami@gmu.edu., Nelson DC; Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA. nelsond@umd.edu.; Department of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA. nelsond@umd.edu.

Publikováno v: Viruses [Viruses] 2018 May 21; Vol. 10 (5). Date of Electronic Publication: 2018 May 21.

Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.

Autor: Che T; Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA., Majumdar S; Molecular Pharmacology Program and Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Zaidi SA; Department of Biological Sciences, Bridge Institute, University of Southern California, Los Angeles, CA 90089, USA., Ondachi P; Center for Organic and Medicinal Chemistry, Research Triangle Institute, Research Triangle Park, NC 27709, USA., McCorvy JD; Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA., Wang S; Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA., Mosier PD; Department of Medicinal Chemistry and Institute for Structural Biology, Drug Discovery and Development, Virginia Commonweath University, Richmond, VA 23298, USA., Uprety R; Molecular Pharmacology Program and Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Vardy E; Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA., Krumm BE; Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA., Han GW; Department of Chemistry, Bridge Institute, University of Southern California, Los Angeles, CA 90089, USA., Lee MY; Department of Chemistry, Bridge Institute, University of Southern California, Los Angeles, CA 90089, USA; School of Molecular Sciences, Biodesign Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA; Institute of Natural Resources and Environmental Audits, Nanjing Audit University, Nanjing, China., Pardon E; Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels, Belgium; VIB-VUB Center for Structural Biology, VIB, 1050 Brussels, Belgium., Steyaert J; Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels, Belgium; VIB-VUB Center for Structural Biology, VIB, 1050 Brussels, Belgium., Huang XP; National Institute of Mental Health Psychoactive Drug Screening Program (NIMH PDSP), School of Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA., Strachan RT; Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA., Tribo AR; Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA., Pasternak GW; Molecular Pharmacology Program and Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Carroll FI; Center for Organic and Medicinal Chemistry, Research Triangle Institute, Research Triangle Park, NC 27709, USA., Stevens RC; Department of Biological Sciences, Bridge Institute, University of Southern California, Los Angeles, CA 90089, USA; Department of Chemistry, Bridge Institute, University of Southern California, Los Angeles, CA 90089, USA., Cherezov V; Department of Chemistry, Bridge Institute, University of Southern California, Los Angeles, CA 90089, USA., Katritch V; Department of Biological Sciences, Bridge Institute, University of Southern California, Los Angeles, CA 90089, USA; Department of Chemistry, Bridge Institute, University of Southern California, Los Angeles, CA 90089, USA., Wacker D; Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA. Electronic address: dwacker@email.unc.edu., Roth BL; Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA; National Institute of Mental Health Psychoactive Drug Screening Program (NIMH PDSP), School of Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA; Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: bryan_roth@med.unc.edu.

Publikováno v: Cell [Cell] 2018 Jan 11; Vol. 172 (1-2), pp. 55-67.e15. Date of Electronic Publication: 2018 Jan 04.

A Hexasaccharide Containing Rare 2-O-Sulfate-Glucuronic Acid Residues Selectively Activates Heparin Cofactor II.

Autor: Sankarayanarayanan NV; Department of Medicinal Chemistry and Institute of Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Richmond, VA, USA., Strebel TR; Centre for Synthesis and Chemical Biology, University College of Dublin, Belfield, Dublin, 4, Ireland., Boothello RS; Department of Medicinal Chemistry and Institute of Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Richmond, VA, USA., Sheerin K; Centre for Synthesis and Chemical Biology, University College of Dublin, Belfield, Dublin, 4, Ireland., Raghuraman A; Department of Medicinal Chemistry and Institute of Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Richmond, VA, USA., Sallas F; Centre for Synthesis and Chemical Biology, University College of Dublin, Belfield, Dublin, 4, Ireland., Mosier PD; Department of Medicinal Chemistry and Institute of Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Richmond, VA, USA., Watermeyer ND; Centre for Synthesis and Chemical Biology, University College of Dublin, Belfield, Dublin, 4, Ireland., Oscarson S; Centre for Synthesis and Chemical Biology, University College of Dublin, Belfield, Dublin, 4, Ireland., Desai UR; Department of Medicinal Chemistry and Institute of Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Richmond, VA, USA.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2017 Feb 20; Vol. 56 (9), pp. 2312-2317. Date of Electronic Publication: 2017 Jan 26.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.