Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Moshe J. Sadofsky"'
Publikováno v:
Academic Pathology, Vol 8 (2021)
Medical schooling, at least as structured in the United States and Canada, is commonly assembled intuitively or empirically to meet concrete goals. Despite a long history of scholarship in educational theory to address how people learn, this is rarel
Externí odkaz:
https://doaj.org/article/b0b4e15da1b34067bc985f56ce0d3ccf
Autor:
Susan A. Kirch, Moshe J. Sadofsky
Publikováno v:
Academic Pathology
Academic Pathology, Vol 8 (2021)
Academic Pathology, Vol 8 (2021)
Medical schooling, at least as structured in the United States and Canada, is commonly assembled intuitively or empirically to meet concrete goals. Despite a long history of scholarship in educational theory to address how people learn, this is rarel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bb6201b8ba8668c0a7b0c7f9eed814c
https://pubmed.ncbi.nlm.nih.gov/33959676
https://pubmed.ncbi.nlm.nih.gov/33959676
Autor:
Radhashree Maitra, Moshe J. Sadofsky
Publikováno v:
Nucleic Acids Research
More than one-third of the RAG1 protein can be truncated from the N-terminus with only subtle effects on the products of V(D)J recombination in vitro or in a mouse. What, then, is the function of the N-terminal domain? We believe it to be regulatory.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7c40c00f91ba96ed5e6451c41ffb771
https://doi.org/10.1093/nar/gkp192
https://doi.org/10.1093/nar/gkp192
Autor:
James Hulit, Boumediene Bouzahzah, Fnu Nagajyothi, Moshe J. Sadofsky, Vicki L. Braunstein, Chris Albanese, Richard G. Pestell, Michael P. Lisanti, Hannah Weiss, Fabiana S. Machado, Herbert B. Tanowitz, Shankar Mukherjee, Vyacheslav Yurchenko
Publikováno v:
Cell Cycle. 7:500-503
Infection with the parasite Trypanosoma cruzi causes Chagas disease. In this study we demonstrated that there was an increase in cyclin D1 expression in T. cruzi (Tulahuen strain)-infected myoblasts. To examine a possible mechanism for the increased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::582a7453a51481d61ea694acf771cb31
https://doi.org/10.4161/cc.7.4.5327
https://doi.org/10.4161/cc.7.4.5327
Publikováno v:
Molecular and Cellular Biology. 26:1786-1794
The nonhomologous end-joining (NHEJ) pathway is responsible for rejoining the majority of double-strand breaks in mammalian cells, including the programmed breaks introduced by V(D)J recombination. The regulation of the enzymatic activities associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f6ac82df19a716bd756897195288382
https://doi.org/10.1128/mcb.26.5.1786-1794.2006
https://doi.org/10.1128/mcb.26.5.1786-1794.2006
Autor:
Moshe J. Sadofsky
Publikováno v:
Academic Pathology, Vol 4 (2017)
The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce71df829752770cdbd10359a77aff04
https://doi.org/10.1177/2374289517711714
https://doi.org/10.1177/2374289517711714
Publikováno v:
Archives of pathologylaboratory medicine. 138(3)
Context.—Medical school education has evolved from department-specific memorization of facts to an integrated curriculum presenting knowledge in a contextual manner across traditional disciplines, integrating information, improving retention, and f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::044c71932028b5db8da6796d724d0577
https://pubmed.ncbi.nlm.nih.gov/24576027
https://pubmed.ncbi.nlm.nih.gov/24576027
Autor:
Moshe J. Sadofsky
Publikováno v:
Nucleic Acids Research. 29:1399-1409
V(D)J recombination is the process that generates the diversity among T cell receptors and is one of three mechanisms that contribute to the diversity of antibodies in the vertebrate immune system. The mechanism requires precise cutting of the DNA at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18c89141e3ca61af0a564b014073e771
https://doi.org/10.1093/nar/29.7.1399
https://doi.org/10.1093/nar/29.7.1399
Publikováno v:
Nucleic Acids Research. 28:1228-1236
Central to understanding the process of V(D)J recombination is appreciation of the protein-DNA complex which assembles on the recombination signal sequences (RSS). In addition to RAG1 and RAG2, the protein HMG1 is known to stimulate the efficiency of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dffe5583b2ffb83fb773d3687c0ab6d
https://doi.org/10.1093/nar/28.5.1228
https://doi.org/10.1093/nar/28.5.1228
Publikováno v:
Journal of Biological Chemistry. 274:7025-7031
An essential step in the development of the vertebrate immune system is the DNA level rearrangement of the antigen receptor genes. This process, termed "V(D)J recombination," begins with DNA cleavage at the appropriate sites mediated by the two prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ce1fb35bb18fd651d0bdd5a2280766
https://doi.org/10.1074/jbc.274.11.7025
https://doi.org/10.1074/jbc.274.11.7025