Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Moshe Hacham"'
Autor:
Tibor Valyi-Nagy, Jack Gibbons, John C. Panepinto, Yoshinori Ohsumi, Guowu Hu, H. Ari Jaffe, Moshe Hacham, Keisuke Obara, Scott R. Waterman, Soowan Shin, Xiaoguang Liu, Peter R. Williamson
Publikováno v:
J. Clin. Invest.. 118(No. 3):1186-1197
Autophagy is a process by which cells recycle cytoplasm and defective organelles during stress situations such as nutrient starvation. It can also be used by host cells as an immune defense mechanism to eliminate infectious pathogens. Here we describ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e1bfd1b1b8a0a95547074e1258d5621
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100724273
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100724273
Autor:
Shahid Husain, Moshe Hacham, Scott R. Waterman, Soowan Shin, Nina Singh, Tibor Valyi-Nagy, Xudong Zhu, Peter R. Williamson, Guowu Hu, Craig A. Beam, Yoon-Dong Park, John C. Panepinto
Publikováno v:
Journal of Clinical Investigation. 117:794-802
The study of regulatory networks in human pathogens such as Cryptococcus neoformans provides insights into host-pathogen interactions that may allow for correlation of gene expression patterns with clinical outcomes. In the present study, deletion of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796766577112ab69ec1561da46b49f81
https://doi.org/10.1172/jci30006
https://doi.org/10.1172/jci30006
Autor:
Shirong Zhang, Xudong Zhu, John C. Panepinto, Soowan Shin, Peter R. Williamson, Moshe Hacham, Guowu Hu
Publikováno v:
Molecular Microbiology. 62:1090-1101
Hsp70 proteins are a well-known class of chaperones that have also been described to have roles in cellular regulation. Here, we show that a Cryptococcus neoformans Hsp70 homologue Ssa1 acts as a DNA-binding transcriptional co-activator of the fungal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6554a27c6b5df3b0cbad5332904c476
https://doi.org/10.1111/j.1365-2958.2006.05422.x
https://doi.org/10.1111/j.1365-2958.2006.05422.x
Publikováno v:
Journal of Antimicrobial Chemotherapy. 55:713-720
OBJECTIVES To investigate the possibilities that: (i) organ toxicity of amphotericin B-deoxycholate (AMB-DOC) is related to induction of interleukin-1beta (IL-1beta), tumour necrosis factor-alpha (TNF-alpha) and apoptosis in target organs; and (ii) t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be54e944315181b1db31098ada35247a
https://doi.org/10.1093/jac/dki090
https://doi.org/10.1093/jac/dki090
Autor:
Xiaoguang Liu, Soowan Shin, Kazimierz W. Komperda, Moshe Hacham, John C. Panepinto, Peter R. Williamson
Publikováno v:
Infection and immunity. 75(10)
Mannan binding lectin (MBL) is an innate immune mediator belonging to the collectin family known to bind to the surfaces of many viruses, bacteria, and fungi. However, pathogenic strains of the fungusCryptococcus neoformansare resistant to MBL bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b1c7aeadadcbd6fa0dcfa5a69d5d61b
https://pubmed.ncbi.nlm.nih.gov/17646356
https://pubmed.ncbi.nlm.nih.gov/17646356
Autor:
Scott R. Waterman, Soowan Shin, John C. Panepinto, Guowu Hu, Moshe Hacham, Peter R. Williamson
Laccase is a major virulence factor of the pathogenic fungus Cryptococcus neoformans , which afflicts both immunocompetent and immunocompromised individuals. In the present study, laccase was expressed in C. neoformans lac1 Δ cells as a fusion prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6f0f89b7fdacf365170a241f02eff78
https://europepmc.org/articles/PMC1828480/
https://europepmc.org/articles/PMC1828480/
Publikováno v:
European cytokine network. 13(1)
The different physiological roles of interleukin-1alpha (IL-1alpha) and interleukin-1beta (IL-1beta) are not well understood, especially when considering the apparent overlap and redundancy of the two IL-1 molecules. Characterization of IL-1alpha and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e5c3be7ca35201d5fee0f79825d2fea6
https://pubmed.ncbi.nlm.nih.gov/11956021
https://pubmed.ncbi.nlm.nih.gov/11956021
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9780306464096
The findings presented in this work show that IL-1α and IL-1β display differential and even inverse patterns of organ expression, demonstrated most clearly at old age and beyond the realm of immunology. Based on these IL- 1α /IL- 1β specific patt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e6354dc17c70d2638f56c940bd3fc22
https://doi.org/10.1007/0-306-46831-x_16
https://doi.org/10.1007/0-306-46831-x_16
Complementary organ expression of IL-1 vs. IL-6 and CSF-1 activities in normal and LPS-injected mice
Publikováno v:
Cytokine. 8(1)
The specific expression of pro-inflammatory cytokines may affect the functioning of organs in different ways. The results of specific cytokine bioassays used in this study show a distinct pattern of tissue expression of IL-1 IL-6 and CSF-1. Cytokine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d96741e53a79fe559bde781da5281ca
https://pubmed.ncbi.nlm.nih.gov/8742063
https://pubmed.ncbi.nlm.nih.gov/8742063
Autor:
Tatyana Dvorkin, Mahmoud Huleihel, Daniel Benharroch, Moshe Hacham, Elena Voronov, Noa Shimoni, Amos Douvdevani, Eyal Fima, Margot Zöller, Ron N. Apte, Shraga Segal, Rosalyn M. White
Publikováno v:
Immunology letters. 39(1)
A direct correlation between the constitutive expression of IL-1α and reduced tumorigenicity of fibrosarcomas was observed. This was established in fibrosarcoma cell lines which produce IL-1α ‘spontaneously’, possibly as an aberration of oncoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2921e595411de35dda775bdffa887dd2
https://pubmed.ncbi.nlm.nih.gov/8144190
https://pubmed.ncbi.nlm.nih.gov/8144190