Zobrazeno 1 - 10
of 219
pro vyhledávání: '"Moshe Gavish"'
Autor:
Daniel Dahis, Dana Meron Azagury, Fadi Obeid, Michelle Z. Dion, Alexander M. Cryer, Mariana Alonso Riquelme, Pere Dosta, Ariel William Abraham, Moshe Gavish, Natalie Artzi, Yosi Shamay, Haim Azhari
Publikováno v:
Advanced NanoBiomed Research, Vol 3, Iss 2, Pp n/a-n/a (2023)
Glioblastoma (GBM) is a universally lethal form of brain cancer. The success of novel treatments is hindered by the blood–brain barrier (BBB), which prevents most drugs from penetrating GBM tumors. Sorafenib (SFB), a proapoptotic multikinase inhibi
Externí odkaz:
https://doaj.org/article/4310b2822e0f444781149b5ebef51b43
Publikováno v:
Biomolecules, Vol 12, Iss 10, p 1397 (2022)
The mitochondrial translocator protein (TSPO) is a modulator of the apoptotic pathway involving reactive oxygen species (ROS) generation, mitochondrial membrane potential (Δψm) collapse, activation of caspases, and eventually initiation of the apop
Externí odkaz:
https://doaj.org/article/7d72dd8249154791896eff5310f74ac9
Autor:
Sheelu Monga, Basem Fares, Rami Yashaev, Dov Melamed, Meygal Kahana, Fuad Fares, Abraham Weizman, Moshe Gavish
Publikováno v:
Journal of Fungi, Vol 8, Iss 3, p 321 (2022)
Macrophages are some of the most important immune cells in the organism and are responsible for creating an inflammatory immune response in order to inhibit the passage of microscopic foreign bodies into the blood stream. Sometimes, their activation
Externí odkaz:
https://doaj.org/article/38da19400c614524a7ba7d33ec259544
Autor:
Sheelu Monga, Nunzio Denora, Valentino Laquintana, Massimo Franco, Ilan Marek, Sukhdev Singh, Rafi Nagler, Abraham Weizman, Moshe Gavish
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 5, Iss , Pp 100083- (2020)
We have shown previously, that the 18 kDa translocator protein (TSPO) synthetic ligands quinazoline derivatives (2-Cl-MGV-1 and MGV-1) can inhibit activation of in BV-2 microglial cells. In the present study we assessed the impact of novel TSPO li
Externí odkaz:
https://doaj.org/article/156ee8fcc2d24c63945c6455eed21e2b
Autor:
Sheelu Monga, Nunzio Denora, Valentino Laquintana, Rami Yashaev, Abraham Weizman, Moshe Gavish
Publikováno v:
Biology, Vol 10, Iss 11, p 1183 (2021)
Parkinson’s disease (PD) is a progressive neurodegenerative disorder which is characterized by the degeneration of dopaminergic neurons in substantia nigra (SN). Oxidative stress or reactive oxygen species (ROS) generation was suggested to play a r
Externí odkaz:
https://doaj.org/article/bd900747fabb46318c988454486df745
Autor:
Nidal Zeineh, Rafael M. Nagler, Martin Gabay, Fadi Obeid, Meygal Kahana, Abraham Weizman, Moshe Gavish
Publikováno v:
Biology, Vol 10, Iss 5, p 395 (2021)
TSPO is involved in cigarette smoke (CS)-induced cellular toxicity, which may result in oral and pulmonary diseases and lung cancer. H1299 lung cancer cells were exposed directly to CS. The H1299 cells were pretreated with our TSPO ligands MGV-1 and
Externí odkaz:
https://doaj.org/article/d91f06dad12c48e0ace84cdc33918fb8
Autor:
Catalina Alamón, Belén Dávila, María Fernanda García, Carina Sánchez, Mariángeles Kovacs, Emiliano Trias, Luis Barbeito, Martín Gabay, Nidal Zeineh, Moshe Gavish, Francesc Teixidor, Clara Viñas, Marcos Couto, Hugo Cerecetto
Publikováno v:
Cancers, Vol 12, Iss 11, p 3423 (2020)
Malignant gliomas are the most common malignant and aggressive primary brain tumors in adults, the prognosis being—especially for glioblastomas—extremely poor. There are no effective treatments yet. However, tyrosine kinase receptor (TKR) inhibit
Externí odkaz:
https://doaj.org/article/af886fa2bed34fa4a4df14a4a3e03c73
Publikováno v:
Biology, Vol 9, Iss 9, p 291 (2020)
The impact of ligands of the 18 kDa translocator protein (TSPO) on the release of chemokines is not vastly investigated. In the present study, we assessed the effect of our novel TSPO ligands 2-Cl-MGV-1 and 2,4-Di-Cl-MGV-1 compared to the classical T
Externí odkaz:
https://doaj.org/article/9e7df01cf7424a7799e71f488f33098c
Autor:
Nidal Zeineh, Nunzio Denora, Valentino Laquintana, Massimo Franco, Abraham Weizman, Moshe Gavish
Publikováno v:
Biomedicines, Vol 8, Iss 5, p 106 (2020)
The 18 kDa translocator protein (TSPO) plays an important role in apoptotic cell death, including apoptosis induced by the hypoxia mimicking agent cobalt chloride (CoCl2). In this study, the protective effects of a high (CB86; Ki = 1.6 nM) and a low
Externí odkaz:
https://doaj.org/article/acbc2c8fd6344135b21b421e2f3549a9
Publikováno v:
Cells, Vol 8, Iss 7, p 694 (2019)
The 18 kDa translocator protein (TSPO) is an initiator of the mitochondrial apoptosis cascade. Cigarette smoke (CS) exposure provokes alterations in TSPO expression as well as upregulation of its related functions such as mitochondrial membrane poten
Externí odkaz:
https://doaj.org/article/52a1675a7f254126a7a45374983a4d03