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Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever.

Autor: Kotliar D; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA. dkotliar@mgb.org.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA. dkotliar@mgb.org.; Department of Internal Medicine, Brigham and Women's Hospital, Boston, MA, USA. dkotliar@mgb.org., Raju S; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA., Tabrizi S; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Odia I; Institute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Goba A; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Momoh M; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone.; Eastern Polytechnic College, Kenema, Sierra Leone., Sandi JD; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Nair P; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Phelan E; Prospr at Work Inc., Berlin, Germany., Tariyal R; NextGen Jane, Inc., Oakland, CA, USA., Eromon PE; Institute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Nigeria.; African Centre of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Nigeria., Mehta S; Department of Critical Care Medicine, University of Maryland Medical Center, Baltimore, MA, USA., Robles-Sikisaka R; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Siddle KJ; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA., Stremlau M; Equator Labs Incorporated, Washington, DC, USA., Jalloh S; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Gire SK; NextGen Jane, Inc., Oakland, CA, USA., Winnicki S; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA., Chak B; Biological Sciences Division, University of Chicago, Chicago, IL, USA., Schaffner SF; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA., Pauthner M; Vir Biotechnology, San Francisco, CA, USA., Karlsson EK; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Genomics and Computational Biology, UMass Chan Medical School, Worcester, MA, USA.; Program in Molecular Medicine, UMass Chan Medical School, Worcester, MA, USA., Chapin SR; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA., Kennedy SG; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Branco LM; Zalgen Labs, Frederick, MD, USA., Kanneh L; Viral Hemorrhagic Fever Program, Kenema Government Hospital, Ministry of Health and Sanitation, Kenema, Sierra Leone., Vitti JJ; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA., Broodie N; New York-Presbyterian Hospital-Columbia and Cornell, New York, NY, USA., Gladden-Young A; Molecular Microbiology, Graduate School of Biomedical Sciences, Tufts University, Boston, MA, USA., Omoniwa O; Malaria Consortium, Abuja, Nigeria., Jiang PP; Google Medical Brain, Mountain View, CA, USA., Yozwiak N; Gene and Cell Therapy Institute, Mass General Brigham, Cambridge, MA, USA., Heuklom S; San Francisco Community Health Center, San Francisco, CA, USA., Moses LM; Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA., Akpede GO; Institute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Nigeria.; Department of Medicine, Ambrose Alli University, Ekpoma, Nigeria., Asogun DA; Department of Community Medicine, Ambrose Alli University, Ekpoma, Nigeria., Rubins K; National Aeronautics and Space Administration, Houston, TX, USA., Kales S; The Jackson Laboratory, Bar Harbor, ME, USA., Happi AN; African Centre of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Nigeria., Iruolagbe CO; Department of Medicine, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Dic-Ijiewere M; Department of Medicine, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Iraoyah K; Department of Medicine, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Osazuwa OO; Department of Medicine, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Okonkwo AK; Department of Medicine, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Kunz S; Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland., McCormick JB; UTHealth Houston School of Public Health, Brownsville Campus, Brownsville, TX, USA., Khan SH; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Honko AN; Boston University School of Medicine, Boston, MA, USA., Lander ES; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA.; Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA., Oldstone MBA; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Hensley L; National Institutes of Health Integrated Research Facility, Frederick, MA, USA., Folarin OA; African Centre of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Nigeria.; Department of Biological Sciences, Redeemer's University, Ede, Nigeria., Okogbenin SA; Institute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Günther S; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany., Ollila HM; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Tewhey R; The Jackson Laboratory, Bar Harbor, ME, USA., Okokhere PO; Institute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Nigeria.; Department of Medicine, Ambrose Alli University, Ekpoma, Nigeria.; Department of Medicine, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Schieffelin JS; Section of Infectious Disease, Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA, USA., Andersen KG; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Reilly SK; Department of Genetics, Yale School of Medicine, New Haven, CT, USA., Grant DS; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone.; Viral Hemorrhagic Fever Program, Kenema Government Hospital, Ministry of Health and Sanitation, Kenema, Sierra Leone., Garry RF; Tulane University School of Medicine, New Orleans, LA, USA., Barnes KG; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.; Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Kamuzu University of Health Sciences, Blantyre, Malawi.; Department of Vector Biology and Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, UK., Happi CT; African Centre of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Nigeria. happic@run.edu.ng.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA. happic@run.edu.ng.; Department of Biological Sciences, Redeemer's University, Ede, Nigeria. happic@run.edu.ng., Sabeti PC; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA. pardis@broadinstitute.org.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. pardis@broadinstitute.org.; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA. pardis@broadinstitute.org.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA. pardis@broadinstitute.org.; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. pardis@broadinstitute.org.; Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA. pardis@broadinstitute.org.

Publikováno v: Nature microbiology [Nat Microbiol] 2024 Mar; Vol. 9 (3), pp. 751-762. Date of Electronic Publication: 2024 Feb 07.

A molecular and epidemiological study of Vibrio cholerae isolates from cholera outbreaks in southern Ghana.

Autor: Danso EK; Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Accra, Ghana.; West African Centre for Cell Biology of Infectious Pathogens, University of Ghana Legon, Legon, Accra, Ghana.; Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Legon, Accra, Ghana., Asare P; Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Accra, Ghana., Otchere ID; Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Accra, Ghana., Akyeh LM; Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Accra, Ghana., Asante-Poku A; Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Accra, Ghana., Aboagye SY; Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Accra, Ghana.; Institute for Environment and Sanitation Studies, University of Ghana, Legon, Accra, Ghana., Osei-Wusu S; Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Accra, Ghana., Opare D; National Public Health and Reference Laboratory, Accra, Ghana., Ntoumi F; Université Marien NGouabi, Fondation Congolaise pour la Recherche Médicale (FCRM), Brazzaville, Congo.; Institute for Tropical Medicine, University of Tübingen, Tübingen, Germany., Zumla A; Division of Infection and Immunity, University College London and NIHR Biomedical Research Centre, UCL Hospitals NHS Foundation Trust, London, England, United Kingdom., Duodu S; West African Centre for Cell Biology of Infectious Pathogens, University of Ghana Legon, Legon, Accra, Ghana.; Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Legon, Accra, Ghana., Yeboah-Manu D; Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Accra, Ghana.; West African Centre for Cell Biology of Infectious Pathogens, University of Ghana Legon, Legon, Accra, Ghana.

Publikováno v: PloS one [PLoS One] 2020 Jul 10; Vol. 15 (7), pp. e0236016. Date of Electronic Publication: 2020 Jul 10 (Print Publication: 2020).