Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Moses Kortok"'
Autor:
Sammy Wambua, Tabitha W Mwangi, Moses Kortok, Sophie M Uyoga, Alex W Macharia, Jedidah K Mwacharo, David J Weatherall, Robert W Snow, Kevin Marsh, Thomas N Williams
Publikováno v:
PLoS Medicine, Vol 3, Iss 5, p e158 (2006)
BackgroundThe alpha-thalassaemias are the commonest genetic disorders of humans. It is generally believed that this high frequency reflects selection through a survival advantage against death from malaria; nevertheless, the epidemiological descripti
Externí odkaz:
https://doaj.org/article/a8c6f8bc992443bd84605921228b2e50
Autor:
Thomas N Williams, Tabitha W Mwangi, David J Roberts, Neal D Alexander, David J Weatherall, Sammy Wambua, Moses Kortok, Robert W Snow, Kevin Marsh
Publikováno v:
PLoS Medicine, Vol 2, Iss 5, p e128 (2005)
BackgroundMalaria resistance by the sickle cell trait (genotype HbAS) has served as the prime example of genetic selection for over half a century. Nevertheless, the mechanism of this resistance remains the subject of considerable debate. While it pr
Externí odkaz:
https://doaj.org/article/889a87dfa60647b68a75bda6e78d1eb9
Autor:
John N. Waitumbi, Abdullah Sayied Abdullah, Martin Rono, Moses Kortok, Mary Nyonda, Margaret J. Mackinnon, Zbynek Bozdech, Kevin Marsh, Mohammed M. Elfaki, Ibrahim M. Elhassan, Joan Simam, Sachel Mok, Joyce M. Ngoi
Publikováno v:
Nat Ecol Evol
Success in eliminating malaria will depend on whether parasite evolution outpaces control efforts. Here, we show that Plasmodium falciparum parasites (the deadliest of the species causing human malaria) found in low-transmission-intensity areas have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1b24b712bd6b5d4de02733d1e54e586
https://ora.ox.ac.uk/objects/uuid:ccaa2ae1-40a4-4fc5-9fb0-b0cc44af4ffc
https://ora.ox.ac.uk/objects/uuid:ccaa2ae1-40a4-4fc5-9fb0-b0cc44af4ffc
Autor:
Thomas N. Williams, Alex K. Chemtai, Alice M Nyakeriga, Jeffrey R. Dorfman, Moses Kortok, Rune Bäck, Marita Troye-Blomberg, Kevin Marsh, Neal Alexander
Both iron deficiency and malaria are common in much of sub-Saharan Africa, and the interaction between these conditions is complex. To investigate the association between nutritional iron status, immunoglobulins, and clinical Plasmodium falciparum ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ca0947ddcd91583180bd91532cfcbe
https://ora.ox.ac.uk/objects/uuid:c8f36296-f716-46c3-b02e-3e05a502b3ec
https://ora.ox.ac.uk/objects/uuid:c8f36296-f716-46c3-b02e-3e05a502b3ec
Autor:
Neil Hall, Sue Kyes, Chris I. Newbold, Michael A. Quail, Kevin Marsh, Moses Kortok, Peter C. Bull, Matthew Berriman
Publikováno v:
PLoS Pathogens, Vol 1, Iss 3, p e26 (2005)
PLoS Pathogens
PLoS Pathogens
The variant surface antigens expressed on Plasmodium falciparum–infected erythrocytes are potentially important targets of immunity to malaria and are encoded, at least in part, by a family of var genes, about 60 of which are present within every p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dfa92984daa8f3e9c899a9b5272e936
https://doi.org/10.1371/journal.ppat.0010026
https://doi.org/10.1371/journal.ppat.0010026
Autor:
Peter C. Bull, Bernard Guyah, Moses Kortok, José A. Stoute, Sue Kyes, Caroline O. Buckee, Vandana Thathy, Chris I. Newbold, Kevin Marsh
Publikováno v:
Molecular Microbiology
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a potentially important family of immune targets, encoded by an extremely diverse gene family called var. Understanding of the genetic organization of var genes is hampered by sequence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a718f790d8009718b8f94c063ea054e
https://doi.org/10.1111/j.1365-2958.2008.06248.x
https://doi.org/10.1111/j.1365-2958.2008.06248.x
Publikováno v:
Scopus-Elsevier
Europe PubMed Central
Europe PubMed Central
Early methods for the detection of single-nucleotide polymorphisms (SNPs) were based on restriction fragment length polymorphism analysis (1) and the effects of base-pair changes on DNA fragment melting temperatures (denaturing gradient gel electroph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b35457971b08e36b6ded9fff68f7b93
https://ora.ox.ac.uk/objects/uuid:2d2831ff-8678-435e-bd18-fff99b33ea52
https://ora.ox.ac.uk/objects/uuid:2d2831ff-8678-435e-bd18-fff99b33ea52
Autor:
Tabitha W. Mwangi, Moses Kortok, Thomas N. Williams, Robert W. Snow, David J. Weatherall, Kevin Marsh, Sammy Wambua, David J. Roberts, Neal Alexander
Publikováno v:
PLoS Medicine, Vol 2, Iss 5, p e128 (2005)
PLoS Medicine
PLoS Medicine
Background Malaria resistance by the sickle cell trait (genotype HbAS) has served as the prime example of genetic selection for over half a century. Nevertheless, the mechanism of this resistance remains the subject of considerable debate. While it p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a021c62f3e8caa6aba36e2b2486447
https://doi.org/10.1371/journal.pmed.0020128
https://doi.org/10.1371/journal.pmed.0020128
Autor:
Chris I. Newbold, Kevin Marsh, Peter C. Bull, Sue Kyes, Jacqui Montgomery, Caroline O. Buckee, Moses Kortok
Publikováno v:
Molecular and Biochemical Parasitology
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) appears to play an key role as both a virulence factor and as a target of naturally acquired immunity [1,2]. This large family of molecules is encoded by the highly polymorphic superfamily
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94b693344fec12e89b6a6a4e19c99844
https://doi.org/10.1016/j.molbiopara.2007.03.011
https://doi.org/10.1016/j.molbiopara.2007.03.011
Autor:
Brett Lowe, Kathryn J. H. Robson, Adrian V. S. Hill, Keith Hart, Magdalena Plebanski, Kevin Marsh, Kennedy Odhiambo, Colin M. Gelder, Moses Kortok, Tabitha W. Mwangi, Eric G. Sheu, Katie L. Flanagan
Publikováno v:
Scopus-Elsevier
Malaria vaccines based on thrombospondin-related adhesive protein of Plasmodium falciparum (Pf TRAP) are currently undergoing clinical trials in humans. This study was designed to investigate naturally acquired cellular immunity to Pf TRAP in adults
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a14ce8a085febbe36376b79a05e00e29
https://doi.org/10.4269/ajtmh.2006.74.367
https://doi.org/10.4269/ajtmh.2006.74.367