Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Moses J. Namkung"'
Publikováno v:
Alcoholism: Clinical and Experimental Research. 20:942-947
Enzymatic catalysis of the oxidations of ethanol, all-trans-retinol (tretinol) and all-trans-retinal (t-retinal) were demonstrated in the cytosolic fractions of rat conceptal homogenates at day 12 of gestation. Products of the retinoid oxidation reac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5918e808bc99d8b5cdbd975c3b087c95
https://doi.org/10.1111/j.1530-0277.1996.tb05275.x
https://doi.org/10.1111/j.1530-0277.1996.tb05275.x
Publikováno v:
Teratology. 54:12-19
Whole rat conceptuses (10.5 gestational days) were explanted into a culture medium containing all-trans-retinol (t-retinol, vitamin A1), ethanol, or combinations of the two alcohols at various concentrations, and were cultured at 37°C for 24 hr. Par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55d82c1ee3ca71267e22e53e486242b6
https://doi.org/10.1002/(sici)1096-9926(199607)54:1<12::aid-tera2>3.0.co
https://doi.org/10.1002/(sici)1096-9926(199607)54:1<12::aid-tera2>3.0.co
Publikováno v:
Toxicology and Applied Pharmacology. 128:129-137
Benzene and several of its metabolites were investigated for dysmorphogenic and embryotoxic effects after direct exposures of cultured whole rat conceptuses. Benzene produced no statistically significant effects at concentrations up to 1.6 mM. Inclus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f08a5917127d5e15de6b67b1d03422
https://doi.org/10.1006/taap.1994.1190
https://doi.org/10.1006/taap.1994.1190
Publikováno v:
Biochemical pharmacology. 50(8)
Catalysis of the oxidation of all-trans-retinol (vitamin A1) or of all-trans-retinal to all-trans-retinoic acid (all-trans-RA) by rat conceptal enzymes was investigated during organogenesis. Products of the reaction were identified and quantified wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c32fa03be84196bc0d50679f4fbdcb71
https://pubmed.ncbi.nlm.nih.gov/7488242
https://pubmed.ncbi.nlm.nih.gov/7488242
Publikováno v:
Biochemical pharmacology. 49(5)
Investigations with chemical inhibitors and with inhibitory antibodies specific for cytochrome P4501A-catalyzed ethoxyresorufin (ethoxyphenoxazone) O-deethylation and 2-acetylaminofluorene ( N -2-fluorenylacetamide) ring hydroxylation indicated that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::014dda05f6f6ccd55f590660699a1fd1
https://pubmed.ncbi.nlm.nih.gov/7887987
https://pubmed.ncbi.nlm.nih.gov/7887987
Publikováno v:
Teratology. 48(5)
The rat conceptus biotransforms N-methyl-N-(7-propoxynaphthalene-2-ethyl)hydroxylamine (QAB) in vitro to 7-propoxynaphthalen-2-ylacetic acid (QAA) and six more (M1 to M6) metabolites. Thus far, M4 has been identified as N-demethyl-QAB and M6 as N-des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d71e3123d7334044957b9011ff7234c
https://pubmed.ncbi.nlm.nih.gov/8303612
https://pubmed.ncbi.nlm.nih.gov/8303612
Autor:
B. H. Dvorchik, Moses J. Namkung, Curtis J. Omiecinski, S. T. Chao, Sidney D. Nelson, Mont R. Juchau
Publikováno v:
Developmental Pharmacology and Therapeutics. 2:1-16
Placental and fetal tissues obtained from humans, monkeys, rats and rabbits contained monooxygenases capable of catalyzing the formation of catechol estrogens. Treatments of pregnant rats with phenobarbital, Aroclor 1254, or 3-methylcholanthrene each
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd21ea1e60971a8fb8e85f0d915aa5d9
https://doi.org/10.1159/000481041
https://doi.org/10.1159/000481041
Publikováno v:
Toxicology and Applied Pharmacology. 36:569-584
The effects of a highly toxic herbicide contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) upon rates of hydroxylation of N-2-fluorenylacetamide (FAA) and of benzo[a]-pyrene (BP) were studied in fetal livers, in placentas, maternal livers, and ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4e09adb6821b17200424e307661c8bd
https://doi.org/10.1016/0041-008x(76)90236-2
https://doi.org/10.1016/0041-008x(76)90236-2
Publikováno v:
Toxicology and Applied Pharmacology. 49:171-178
Preparations of S-9 (supernatant fractions of tissue homogenates centrifuged at 9000g for 10 min) fractions from the fetal brains of rats displayed a high capacity to convert 7,12-dimethylbenz(a)anthracene to metabolites mutagenic to Salmonella typhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3c28bfe4c012c5f05a9e4ff31853fe5
https://doi.org/10.1016/0041-008x(79)90288-6
https://doi.org/10.1016/0041-008x(79)90288-6
Publikováno v:
Journal of Steroid Biochemistry. 22:563-567
The effects of nine separate inducers of cytochrome P-450-dependent monooxygenases on the hydroxylation of estradiol-17 beta (E2) were investigated in near-term pregnant rats. Isosafrole exhibited highly effective inducing properties in the maternal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa17b3b727e14838ab7365384dfdc11b
https://doi.org/10.1016/0022-4731(85)90179-7
https://doi.org/10.1016/0022-4731(85)90179-7