Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Moses Bio"'
Autor:
Pritam Thapa, Mengjie Li, Radha Karki, Moses Bio, Pallavi Rajaputra, Gregory Nkepang, Sukyung Woo, Youngjae You
Publikováno v:
ACS Omega, Vol 2, Iss 10, Pp 6349-6360 (2017)
Externí odkaz:
https://doaj.org/article/d1cb7868843a4d84b97a43b8663cefc0
Autor:
Pallavi Rajaputra, Cody J. Peer, Pritam Thapa, Youngjae You, Sukyung Woo, William D. Figg, Mengjie Li, Moses Bio
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics. 44:521-536
The combination of photodynamic therapy (PDT) with anti-tumor agents is a complimentary strategy to treat local cancers. We developed a unique photosensitizer (PS)-conjugated paclitaxel (PTX) prodrug in which a PS is excited by near-infrared waveleng
Autor:
Jessica Kindrick, Cody J. Peer, Bharathiraja Subramaniyan, Moses Bio, Sukyung Woo, Mengjie Li, Luong T. Nguyen, Youngjae You, William D. Figg
Publikováno v:
J Control Release
Photodynamic therapy (PDT) is a clinically approved therapeutic modality to treat certain types of cancers. However, incomplete ablation of tumor is a challenge. Visible and near IR-activatable prodrug, exhibiting the combined effects of PDT and loca
Autor:
Moses Bio, Kazi Md Mahabubur Rahman, Youngjae You, Robert E. Hurst, Pallavi Rajaputra, Irene Lim
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(12)
Systemic side effects and high hydrophobicity are major disadvantages of paclitaxel (PTX), one of the most popular anticancer drugs. Here, we present singlet oxygen (SO)-activatable and mitochondria-targeted PTX prodrugs to overcome these problems an
Publikováno v:
Bioorganic & Medicinal Chemistry. 24(7):1540-1549
Photodynamic therapy (PDT) is a cancer treatment modality where photosensitizer (PS) is activated by visible and near IR light to produce singlet oxygen ((1)O2). However, (1)O2 has a short lifetime (
Publikováno v:
Bioconjugate Chemistry
We examined the concept of a novel prodrug strategy in which anticancer drug can be locally released by visible/near IR light, taking advantage of the photodynamic process and photo-unclick chemistry. Our most recently formulated prodrug of combretas
Autor:
Pritam Thapa, Irene Lim, Youngjae You, Bomaonye Tienabeso, Robert E. Hurst, Pallavi Rajaputra, Moses Bio
Publikováno v:
Chemical communications (Cambridge, England). 53(11)
Photo-unclick chemistry mediates visible and near IR-controlled drug release via a singlet oxygen (SO)-cleavable linker. Due to the limited diffusion distance of SO in biological systems, a photosensitizer and the SO-cleavable linker have been conjug
Publikováno v:
Journal of Medicinal Chemistry
We recently developed “photo-unclick chemistry”, a novel chemical tool involving the cleavage of aminoacrylate by singlet oxygen, and demonstrated its application to visible light-activatable prodrugs. In this study, we prepared an advanced multi
Publikováno v:
ACS Medicinal Chemistry Letters. 4:124-127
We designed and synthesized a novel double activatable prodrug system (drug-linker-deactivated photosensitizer), containing a photocleavable aminoacrylate-linker and a deactivated photosensitizer, to achieve the spatiotemporally controlled release of
Autor:
Youngjae You, Moses Bio, Gregory Nkepang, Sukyung Woo, Mengjie Li, Pritam Thapa, Yajing Sun, Pallavi Rajaputra
Publikováno v:
Journal of medicinal chemistry. 59(7)
Paclitaxel (PTX) is one of the most useful chemotherapeutic agents approved for several cancers, including ovarian, breast, pancreatic, and non-small cell lung cancer. However, it causes systemic side effects when administered parenterally. Photodyna