Metabolismus karcinogenů a léčiv monooxygenasovým systémem

Autor: Moserová, Michaela

Ellipticine, an alkaloid isolated from Apocynaceae plants, exhibits significant antitumor and HIV activities. Ellipticine is a pro-drug, whose pharmacological and genotoxic effects depend on activation by cytochromes P450 (CYP) and peroxidases (Px) t

Externí odkaz: http://www.nusl.cz/ntk/nusl-311556

Induction of cytochromes P450 1A1 and 1A2 suppresses formation of DNA adducts by carcinogenic aristolochic acid I in rats in vivo

Autor: Dračínská, Helena, Bárta, František, Levová, Kateřina, Hudecová, Alena, Moserová, Michaela, Schmeiser, Heinz H., Kopka, Klaus, Frei, Eva, Arlt, Volker M., Stiborová, Marie

Publikováno v: In Toxicology 17 February 2016 344-346:7-18

Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions

Autor: Stiborová, Marie, Moserová, Michaela, Černá, Věra, Indra, Radek, Dračínský, Martin, Šulc, Miroslav, Henderson, Colin J., Wolf, C. Roland, Schmeiser, Heinz H., Phillips, David H., Frei, Eva, Arlt, Volker M.

Publikováno v: In Toxicology 6 April 2014 318:1-12

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The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/-) and Trp53(-/-) mice

Autor: Krais, Annette M., Speksnijder, Ewoud N., Melis, Joost P. M., Indra, Radek, Moserova, Michaela, Godschalk, Roger W., van Schooten, Frederik-J., Seidel, Albrecht, Kopka, Klaus, Schmeiser, Heinz H., Stiborova, Marie, Phillips, David H., Luijten, Mirjam, Arlt, Volker M.

Publikováno v: Krais, A M, Speksnijder, E N, Melis, J P M, Indra, R, Moserova, M, Godschalk, R W, van Schooten, F-J, Seidel, A, Kopka, K, Schmeiser, H H, Stiborova, M, Phillips, D H, Luijten, M & Arlt, V M 2016, ' The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/-) and Trp53(-/-) mice ', Archives of Toxicology, vol. 90, no. 4, pp. 839-851 . https://doi.org/10.1007/s00204-015-1531-8

The tumour suppressor p53 is one of the most important cancer genes. Previous findings have shown that p53 expression can influence DNA adduct formation of the environmental carcinogen benzo[a]pyrene (BaP) in human cells, indicating a role for p53 in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e7fd1fb65206cbf4fa3e2733261c6ffa
https://kclpure.kcl.ac.uk/en/publications/30909f28-aefb-442a-b2b4-f097edeb9d82