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Akademický článek

Transcriptomic profiling of 'brain-eating amoeba' Naegleria fowleri infection in mice: the host and the protozoa perspectives

Autor: Vincent Guerlais, Nina Allouch, E. Ashley Moseman, Alicja W. Wojciechowska, Jakub W. Wojciechowski, Isabel Marcelino

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)

The free-living amoeba Naegleria fowleri (NF) causes a rare but lethal parasitic meningoencephalitis (PAM) in humans. Currently, this disease lacks effective treatments and the specific molecular mechanisms that govern NF pathogenesis and host brain

Externí odkaz: https://doaj.org/article/f37d226e6a254d8aaba65b5dd28ebc4f

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Akademický článek

Necroptosis stimulates interferon-mediated protective anti-tumor immunity

Autor: A. Justin Rucker, Christa S. Park, Qi Jing Li, E. Ashley Moseman, Francis Ka-Ming Chan

Publikováno v: Cell Death and Disease, Vol 15, Iss 6, Pp 1-12 (2024)

Abstract Necroptosis is an inflammatory form of cell suicide that critically depends on the kinase activity of Receptor Interacting Protein Kinase 3 (RIPK3). Previous studies showed that immunization with necroptotic cells conferred protection agains

Externí odkaz: https://doaj.org/article/d67e990c29ab4402ad575a2cd4468203

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Akademický článek

Enolase inhibitors as therapeutic leads for Naegleria fowleri infection.

Publikováno v: PLoS Pathogens, Vol 20, Iss 8, p e1012412 (2024)

Infections with the pathogenic free-living amoebae Naegleria fowleri can lead to life-threatening illnesses including catastrophic primary amoebic meningoencephalitis (PAM). Efficacious treatment options for these infections are lacking and the morta

Externí odkaz: https://doaj.org/article/cb6c340b2bff4f6ca9f6beb1b6aa1504

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Akademický článek

Combining toll-like receptor agonists with immune checkpoint blockade affects antitumor vaccine efficacy

Autor: Donghwan Jeon, Ethan Hill, Jena E Moseman

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 5 (2024)

Background T cell checkpoint receptors are expressed when T cells are activated, and modulation of the expression or signaling of these receptors can alter the function of T cells and their antitumor efficacy. We previously found that T cells activat

Externí odkaz: https://doaj.org/article/36ddc024b52842c5b182893bf71aaf2c

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